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CAMP-regulated phosphoprotein 21

cyclic AMP-regulated phosphoprotein, ARPP-21, cyclic AMP-regulated phosphoprotein of
This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] (from NCBI)
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Top mentioned proteins: ACID, V1a, Ankrd2, HAD, fibrillin-1
Papers on cyclic AMP-regulated phosphoprotein
Stathmin reduction and cytoskeleton rearrangement in rat nucleus accumbens in response to clozapine and risperidone treatment - Comparative proteomic study.
Dziedzicka-Wasylewska et al., Kraków, Poland. In Neuroscience, Jan 2016
RIS tuned cell function by changing the pattern of post-translational modifications of some proteins: it down-regulated the phosphorylated forms of stathmin and dopamine and the cyclic AMP-regulated phosphoprotein (DARPP-32) isoform but up-regulated cyclin-dependent kinase 5 (Cdk5).
GDNF is important for striatal organization and maintenance of dopamine neurons grown in the presence of the striatum.
Strömberg et al., Umeå, Sweden. In Neuroscience, 2014
The TH-positive innervation overlapped with the organization of dopamine and cyclic AMP-regulated phosphoprotein-relative molecular mass 32,000 (DARPP-32)-positive neurons, that was disorganized in LGE lacking GDNF production.
Non-serine-phosphorylated tyrosine hydroxylase expressing neurons are present in mouse striatum, accumbens and cortex that increase in number following dopaminergic denervation.
Depboylu, Marburg an der Lahn, Germany. In J Chem Neuroanat, 2014
These TH neurons were not stained by specific antibodies recognizing TH phosphorylated at serine residues 19, 31 and 40, dopamine transporter and vesicular monoamine transporter type 2, but most of them expressed dopamine and cyclic AMP-regulated phosphoprotein 32kDa.
Ephedrine induced thioredoxin-1 expression through β-adrenergic receptor/cyclic AMP/protein kinase A/dopamine- and cyclic AMP-regulated phosphoprotein signaling pathway.
Bai et al., Kunming, China. In Cell Signal, 2013
Interestingly, the effect of Eph on dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) was similar to Trx-1.
Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2.
Ehrlich et al., New York City, United States. In Plos One, 2012
Exposure of these neurons to each of the three compounds led to an increase in overall histone H3 and H4 acetylation, dopamine and cyclic AMP-regulated phosphoprotein, 32 kDa (DARPP-32) mRNA and protein, and mRNA levels of other markers of medium spiny neuron maturation.
Regulation of ERBB2 receptor by t-DARPP mediates trastuzumab resistance in human esophageal adenocarcinoma.
El-Rifai et al., Nashville, United States. In Cancer Res, 2012
The dopamine and cyclic AMP-regulated phosphoprotein of MR 32000 (DARPP-32), also known as PPP1R1B, is located together with ERBB2 at the 17q12-q21 amplicon.
Dopamine D1 receptors and phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in the medial preoptic area are involved in experience-induced enhancement of male sexual behavior in rats.
Hull et al., Tallahassee, United States. In Behav Neurosci, 2012
The medial preoptic area (MPOA) is an integral site for male sexual behavior.
GABAergic neurons from mouse embryonic stem cells possess functional properties of striatal neurons in vitro, and develop into striatal neurons in vivo in a mouse model of Huntington's disease.
Fricker et al., United Kingdom. In Stem Cell Rev, 2012
Monolayer method-derived GABAergic neurons expressed the MSN marker dopamine- and cyclic AMP-regulated phosphoprotein (DARPP32).
Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits.
Nairn et al., New Haven, United States. In Eur J Neurosci, 2012
these results implicate a novel PKA-regulated phosphoprotein, Regulator of calmodulin signaling, in the etiology of motivational deficits and anxiety.
Chronic levodopa administration followed by a washout period increased number and induced phenotypic changes in striatal dopaminergic cells in MPTP-monkeys.
Luquin et al., Pamplona, Spain. In Plos One, 2011
Double and triple labeling immunofluorescence was performed to detect the neurochemical characteristics of the striatal TH-ir cells using antibodies against: TH, anti-glutamate decarboxylase (GAD(67)) anti-calretinin (CR) anti-dopa decarboxylase (DDC) and anti-dopamine and cyclic AMP-regulated phosphoprotein (DARPP-32).
Postnatal development of tyrosine hydroxylase mRNA-expressing neurons in mouse neostriatum.
Aosaki et al., Tokyo, Japan. In Eur J Neurosci, 2011
Whole-cell patch-clamp recordings revealed at least two distinct neuronal types, termed EGFP-TH+ Type A and B. Whereas Type B neurons were aspiny and negative for the MSN marker dopamine- and cyclic AMP-regulated phosphoprotein of 32 kDa (DARPP-32), Type A neurons constituted 75% of the EGFP+ cells, had dendritic spines (24.6%), contained DARPP-32 (73.6%) and a proportion acquired TH immunoreactivity after injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 3-nitropropionic acid.
Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
Klein et al., Bethesda, United States. In J Biol Chem, 2009
Expression of ARPP21 in the pineal gland increases at night more than 1000%. This probably reflects circadian neural stimulation by the suprachiasmatic nucleus.
[DARPP-32 in the patients with endogenous psychosis].
Mizukami et al., Ibaraki, Japan. In Brain Nerve, 2007
Dopamine- and cyclic AMP-regulated phosphoprotein with a relative molecular weight of 32 kDa (DARPP-32) plays an important role in integrating information of about several neurotransmitters arriving at dopaminoceptive neurons.
Activation of sodium transport in rat erythrocytes by inhibition of protein phosphatases 1 and 2A.
Gusev et al., Saint Petersburg, Russia. In Comp Biochem Physiol B Biochem Mol Biol, 2006
Inhibition of protein phosphatase 1 by protein phosphatase inhibitors activates sodiun transport in rat erytrocytes
A network of control mediated by regulator of calcium/calmodulin-dependent signaling.
Greengard et al., New York City, United States. In Science, 2004
Through a molecular mechanism that amplifies GPCR- & PKA-mediated signaling & attenuates GPCR- & PP2B-mediated signaling, RCS (ARPP-21) synergistically increases phosphorylation of key proteins whose phosphorylation is regulated by PKA and PP2B [RCS]
Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development.
Bedford et al., United States. In J Biol Chem, 2004
CARM1 plays a significant role in promoting the differentiation of early thymocyte progenitors, possibly through its direct action on TARPP.
Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine.
Fisone et al., Stockholm, Sweden. In Nature, 2002
Here we show that the stimulatory effect of caffeine on motor activity in mice was greatly reduced following genetic deletion of DARPP-32 (dopamine- and cyclic AMP-regulated phosphoprotein of relative molecular mass 32,000).
Cyclic GMP-dependent protein kinase and cellular signaling in the nervous system.
Robinson et al., Newcastle, Australia. In J Neurochem, 1997
One clear illustration of this pathway has been reported in striatonigral nerve terminals, where NO mediates phosphorylation of the protein phosphatase regulator dopamine- and cyclic AMP-regulated phosphoprotein having a molecular mass of 32,000 (DARPP-32) by PKG.
DARPP-32 as a marker for D-1 dopaminoceptive cells in the rat brain: prenatal development and presence in glial elements (tanycytes) in the basal hypothalamus.
Greengard et al., Stockholm, Sweden. In Adv Exp Med Biol, 1987
The present article reviews some aspects of the localization of a dopamine- and cyclic AMP-regulated phosphoprotein, DARPP-32, which is assumed to be present in D-1 dopaminoceptive neurons.
A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions.
Greengard et al., In Nature, 1983
Several mammalian neurotransmitter candidates, for example, serotonin, dopamine and noradrenaline, may exert some of their synaptic effects by regulating protein phosphorylation systems.
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