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CYC1 Cyc1p

CYC1
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. The function of this cyclin has not yet been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, lacZ, ACID, POLYMERASE, HAD
Papers on CYC1
Epitope-tagged yeast strains reveal promoter driven changes to 3'-end formation and convergent antisense-transcription from common 3' UTRs.
New
Beilharz et al., Melbourne, Australia. In Nucleic Acids Res, Feb 2016
Here we show that the 3' UTRs, CYC1 and ADH1, contain cryptic promoters that generate abundant convergent antisense-transcription in Saccharomyces cerevisiae.
VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae.
New
Kuge et al., Fukuoka, Japan. In Biochem J, Jan 2016
Furthermore, vid22Δ cells were shown to be defective in expression of the PSD2 gene tagged with 6×HA, the defect being ameliorated by replacement of the native promoter of the PSD2 gene with a CYC1 promoter.
Development of a Tightly Controlled Off Switch for Saccharomyces cerevisiae Regulated by Camphor, a Low-Cost Natural Product.
New
Boeke et al., Yokohama, Japan. In G3 (bethesda), Oct 2015
A suitable promoter responsive to the CamR fusion protein was engineered by embedding a P. putida operator binding sequence within an upstream activating sequence (UAS)-less CYC1 promoter from S. cerevisiae.
Phenotypic variation of TTC19-deficient mitochondrial complex III deficiency: a case report and literature review.
Review
New
Yu et al., Adelaide, Australia. In Am J Med Genet A, Jun 2015
It has been associated with mutations in MT-CYB, the only mitochondrial DNA encoded subunit, as well as in nine nuclear genes described thus far: BCS1L, TTC19, UQCRB, UQCRQ, UQCRC2, CYC1, UQCC2, LYRM7, and UQCC3.
A Random Screen Using a Novel Reporter Assay System Reveals a Set of Sequences That Are Preferred as the TATA or TATA-Like Elements in the CYC1 Promoter of Saccharomyces cerevisiae.
Kokubo et al., Yokohama, Japan. In Plos One, 2014
For this purpose, we conducted a randomized screen of the TATA element in the CYC1 promoter by using a novel reporter assay system and identified several hundreds of unique sequences that were tentatively classified into nine groups.
Immunity of the Saccharomyces cerevisiae SSY5 mRNA to nonsense-mediated mRNA decay.
Kebaara et al., Waco, United States. In Front Mol Biosci, 2013
Replacing the SSY5 3'-UTRs with the cyc1-512 3'-UTRs, known to target mRNAs to NMD or with the CYC1 3'-UTR, known not to target mRNAs to NMD, resulted in production of SSY5 mRNAs that were regulated by NMD.
Probing the dynamics of a His73-heme alkaline transition in a destabilized variant of yeast iso-1-cytochrome c with conformationally gated electron transfer methods.
GeneRIF
Bowler et al., Missoula, United States. In Biochemistry, 2011
His26 is not the source of pK(H1). The data also show that the H26N mutation enhances the dynamics of this conformational transition from pH 5 to 10, likely as a result of destabilization of the protein.
The effects of ATP and sodium chloride on the cytochrome c-cardiolipin interaction: the contrasting behavior of the horse heart and yeast proteins.
GeneRIF
Santucci et al., Roma, Italy. In J Inorg Biochem, 2011
yeast CYC1 displays lower stability and, contrary to the equine protein, it does not bind ATP and lacks pro-apoptotic activity
Propensities of aromatic amino acids versus leucine and proline to induce residual structure in the denatured-state ensemble of iso-1-cytochrome c.
GeneRIF
Bowler et al., Missoula, United States. In J Mol Biol, 2010
Kinetic studies show that change in His-heme loop stability for aromatic amino acids is caused by a slowdown in the rate of loop breakage, indicating that residual structure is preferentially stabilized in the closed-loop form of the denatured state.
Electrostatic effects on funneled landscapes and structural diversity in denatured protein ensembles.
GeneRIF
Wolynes et al., San Diego, United States. In Proc Natl Acad Sci U S A, 2009
simulate the denatured ensemble of cytochrome c using a series of models. Six variants of S cerevisae iso-1-cytochrome c under GuHCl- and acid-denaturing conditions
Alkaline conformational transition and gated electron transfer with a Lys 79 --> his variant of iso-1-cytochrome c.
GeneRIF
Bowler et al., Missoula, United States. In Biochemistry, 2007
These data indicate that acid unfolding is multi-state for both K79H and wild type proteins and that the His 79-heme alkaline conformer is more stable than a previously reported His 73-heme alkaline conformer.
The importance of mutation, then and now: studies with yeast cytochrome c.
Review
Sherman, Rochester, United States. In Mutat Res, 2005
The development of a genetic system based on the CYC1 gene was initiated over 40 years ago, primarily because of the anticipated ease of sequencing of the corresponding encoded protein, iso-1-cytochrome c from Saccharomyces cerevisiae.
Mutagenesis assays in yeast.
Review
Crouse, Atlanta, United States. In Methods, 2000
The assay for base substitution mutations uses a series of six strains with different mutations in one essential codon of the CYC1 gene.
Coupling termination of transcription to messenger RNA maturation in yeast.
Impact
Proudfoot et al., Oxford, United Kingdom. In Science, 1998
The direct association between messenger RNA (mRNA) 3'-end processing and the termination of transcription was established for the CYC1 gene of Saccharomyces cerevisiae.
Control of translation initiation in Saccharomyces cerevisiae.
Review
Donahue et al., Bloomington, United States. In Mol Microbiol, 1992
Elegant genetic studies of the CYC1 gene resulted in the formulation of 'Sherman's Rules' for translation initiation as follows: (i) AUG is the only initiator codon.
Glucose repression in the yeast Saccharomyces cerevisiae.
Review
Trumbly, Toledo, United States. In Mol Microbiol, 1992
In the cases of the GAL genes and possibly CYC1, regulation is mediated by a cascade in which the general pathway represses expression of a positive transcriptional activator.
Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae.
Impact
Alani et al., In Cell, 1984
The upstream activation site (UAS) of the yeast CYC1 gene is shown to contain two homologous subsites, UAS1 and UAS2.
Transcription terminates in yeast distal to a control sequence.
Impact
Cohen et al., In Cell, 1983
At least part of the control region appears to be an 8-base pair (bp) sequence also found in the termination control region of the yeast CYC1 gene.
Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site.
Impact
Mason et al., In Cell, 1983
We show that expression of the iso-1-cytochrome c gene of Saccharomyces cerevisiae, CYC1, is tightly regulated by levels of intracellular heme.
DNA sequence required for efficient transcription termination in yeast.
Impact
Sherman et al., In Cell, 1982
The cyc1-512 mutant produces approximately 10% of the normal amount of the CYC1 gene product, iso-1-cytochrome c, and produces 5%--10% of the normal steady-state amount of CYC1 mRNA.
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