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Gap junction protein, gamma 1

Cx45, connexin45
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: GAP, Connexin 43, Cx40, CAN, V1a
Papers on Cx45
Cardiomyogenesis of embryonic stem cells upon purinergic receptor activation by ADP and ATP.
New
Wartenberg et al., Jena, Germany. In Purinergic Signal, Dec 2015
Cardiac-specific genes showed enhanced expression of α-MHC, MLC2v, α-actinin, connexin 45 (Cx45), and HCN4, on both gene and protein levels upon ADP/ATP treatment, indicating increased cardiomyogenesis and pacemaker cell differentiation.
Expression and Localization of Connexins in the Outer Retina of the Mouse.
New
Janssen-Bienhold et al., Oldenburg, Germany. In J Mol Neurosci, Nov 2015
In addition to connexin36, we detected transcripts for connexin32, connexin43, connexin45, connexin50, and connexin57 in photoreceptor samples.
Connexins and pannexins in the skeleton: gap junctions, hemichannels and more.
Review
New
Stains et al., Indianapolis, United States. In Cell Mol Life Sci, Aug 2015
Connexin43 regulates the expression of genes required for osteoblast and osteoclast differentiation directly or by changing the levels of osteocytic genes, and connexin45 may oppose connexin43 actions in osteoblastic cells.
Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75).
New
Su et al., Honolulu, United States. In Biochem J, Apr 2015
We have discovered two additional connexins, connexin40 (Cx40) and connexin45 (Cx45), that interact with CIP75.
Impact of obesity on 7,12-dimethylbenz[a]anthracene-induced altered ovarian connexin gap junction proteins in female mice.
Keating et al., Ames, United States. In Toxicol Appl Pharmacol, 2015
The ovarian gap junction proteins alpha 4 (GJA4 or connexin 37; CX37), alpha 1 (GJA1 or connexin 43; CX43) and gamma 1 (GJC1 or connexin 45; CX45) are involved in cell communication and folliculogenesis.
Alterations in gap junction connexin43/connexin45 ratio mediate a transition from quiescence to excitation in a mathematical model of the myometrium.
van den Berg et al., In J R Soc Interface, 2015
These cells achieve coordinated activity via electrical connections called gap junctions which consist of aggregated connexin proteins such as connexin43 and connexin45.
The enhancement of Cx45 expression and function in renal interlobar artery of spontaneously hypertensive rats at different age.
Si et al., In Kidney Blood Press Res, 2014
BACKGROUND/AIMS: This study was designed to investigate the expression and function of gap junction protein connexin 45 (Cx45) in renal interlobar artery (RIA) of spontaneously hypertensive rats (SHR), and the association between hypertension and enhanced vasoconstrictive response in SHR.
Characterization of the connexin45 carboxyl-terminal domain structure and interactions with molecular partners.
Sorgen et al., Omaha, United States. In Biophys J, 2014
For example, Cx45 is predominately expressed in the specialized myocytes of the impulse generation and conduction system.
Role of gap junctions in the contractile response to agonists in the mesenteric artery of spontaneously hypertensive rats.
Si et al., Shihezi, China. In Hypertens Res, 2014
(3) The expression of connexin 45 (Cx45) mRNA and protein in the MA was greater in SHR versus WKY rats (P<0.05).
Connexins and steroidogenesis in mouse Leydig cells.
Kidder et al., London, Canada. In Can J Physiol Pharmacol, 2013
A reverse transcription - polymerase chain reaction screen involving isolated adult Leydig cells identified connexin36 and connexin45 as expressed along with connexin43.
An Escherichia coli strain for expression of the connexin45 carboxyl terminus attached to the 4th transmembrane domain.
Sorgen et al., Omaha, United States. In Front Pharmacol, 2012
A major problem for structural characterization of membrane proteins, such as connexins, by nuclear magnetic resonance (NMR) occurs at the initial step of the process, the production of sufficient amounts of protein.
[Remodeling of cardiac gap junctions and arrhythmias].
Review
Sheng et al., Xi'an, China. In Sheng Li Xue Bao, 2012
Three principal connexins are expressed in cardiomyocytes, connexin 43 (CX43), CX40, and CX45.
Residual Cx45 and its relationship to Cx43 in murine ventricular myocardium.
GeneRIF
Yamada et al., Saint Louis, United States. In Channels (austin), 2011
Residual Cx45 and its relationship to Cx43 in murine ventricular myocardium.
The role of neuronal connexins 36 and 45 in shaping spontaneous firing patterns in the developing retina.
GeneRIF
Feller et al., San Diego, United States. In J Neurosci, 2011
The cx45 strongly modulate the firing pattern of individual RGCs, ensuring strongly correlated firing between nearby RGCs and normal patterning of retinogeniculate projections.
DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer.
GeneRIF
Lind et al., Oslo, Norway. In Epigenetics, 2011
DNA hypermethylation of the promoter region of GJC1, encoding connexin45, is an important mechanism in silencing gene expression in colorectal cancer.
Influence of v5/6-His tag on the properties of gap junction channels composed of connexin43, connexin40 or connexin45.
GeneRIF
Weingart et al., Bern, Switzerland. In J Membr Biol, 2011
Study shows that fusion of a V5/6-His tag (hexa moiety M r = 0.93 kDa) to the CT segment of Cx40, Cx43 and Cx45 does not prevent the cells from forming channels.
Cytokine effects on gap junction communication and connexin expression in human bladder smooth muscle cells and suburothelial myofibroblasts.
GeneRIF
Neuhaus et al., Leipzig, Germany. In Plos One, 2010
Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45.
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion.
Review
Sáez et al., Santiago, Chile. In J Membr Biol, 2007
In agreement, hemichannels formed by connexin 45, which lacks cytoplasmic cysteines, or by connexin 43 with its C-terminal domain truncated to remove its cysteines are insensitive to reducing agents.
Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation.
Review
Smith et al., Oxford, United Kingdom. In J Electrocardiol, 2005
More recently, functional myocyte-fibroblast coupling (via connexin 45) has been demonstrated in situ for sinoatrial node pacemaker tissue, and preliminary immunohistochemical data suggest that myocyte-fibroblast coupling may be present in postinfarct scar tissue.
Expression and functions of neuronal gap junctions.
Review
Impact
Willecke et al., Bonn, Germany. In Nat Rev Neurosci, 2005
Gap junctions between murine neurons (also known as electrical synapses) can be composed of connexin 36, connexin 45 or connexin 57 proteins, depending on the type of neuron.
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