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Gap junction protein, alpha 4, 37kDa

Cx37, connexin37
This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GAP, Connexin 43, Cx40, CAN, HAD
Papers on Cx37
Effects of renal denervation on renal pelvic contractions and connexin expression in rats.
New
Grisk et al., Greifswald, Germany. In Acta Physiol (oxf), Feb 2016
Renal denervation did not increase pelvic connexin37, 40, 43 or 45 mRNA abundances.
Smoking impairs and circulating stem cells favour the protective effect of the T allele of the connexin37 gene in ischemic heart disease - A multinational study.
New
Vari et al., Praha, Czech Republic. In Atherosclerosis, Jan 2016
BACKGROUND: The connexin 37 (Cx37) gene is considered to be a candidate gene for ischemic heart disease (IHD).
Shear stress-induced atherosclerotic plaque composition in ApoE(-/-) mice is modulated by connexin37.
New
Kwak et al., Genève, Switzerland. In Atherosclerosis, Nov 2015
Endothelial connexin37 (Cx37) expression is also regulated by shear stress, which may contribute to localization of atherosclerotic disease.
Gap junction connexins in female reproductive organs: implications for women's reproductive health.
Review
New
Kidder et al., London, Canada. In Hum Reprod Update, May 2015
Loss of CX37, which exclusively connects oocytes with granulosa cells in the mouse, caused oocytes to cease growing without acquiring meiotic competence.
MicroRNA-378 regulates oocyte maturation via the suppression of aromatase in porcine cumulus cells.
New
Li et al., Guelph, Canada. In Am J Physiol Endocrinol Metab, Apr 2015
Cumulus cell expression of miR-378 also suppressed oocyte progression from the GV to MII stage (from 54 ± 2.7 to 31 ± 5.1%), accompanied by a decrease of growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), zona pellucida 3 (ZP3), and CX37 in the oocytes.
Specific deletion of AMP-activated protein kinase (α1AMPK) in murine oocytes alters junctional protein expression and mitochondrial physiology.
Froment et al., Tours, France. In Plos One, 2014
In vivo and in cumulus-oocyte complexes, several proteins involved in junctional communication, such as connexin37 and N-cadherin were down-regulated in the absence of α1AMPK.
Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells.
GeneRIF
Kwak et al., Genève, Switzerland. In J Mol Cell Cardiol, 2012
The effect of shear stress on Cx37 expression may contribute to the synchronization of ECs and participate in the protective effect of HLSS.
Gap junctions and connexin hemichannels underpin hemostasis and thrombosis.
GeneRIF
Gibbins et al., Reading, United Kingdom. In Circulation, 2012
We report the presence of connexins in platelets, notably connexin37, and that the formation of gap junctions within platelet thrombi is required for the control of clot retraction.
Lack of association between a functional genetic variant of connexin 37 and ischemic stroke in a Taiwanese population.
GeneRIF
Lin et al., Kao-hsiung, Taiwan. In Thromb Res, 2012
GJA4 polymorphism is not associated with stroke risk in the Taiwanese population.
Cx40 is required for, and cx37 limits, postischemic hindlimb perfusion, survival and recovery.
GeneRIF
Burt et al., Tucson, United States. In J Vasc Res, 2011
Cx40 is required for, and cx37 limits, postischemic hindlimb perfusion, survival and recovery.
Risky communication in atherosclerosis and thrombus formation.
Review
Kwak et al., Genève, Switzerland. In Swiss Med Wkly, 2011
Multiple epidemiological studies have associated a single nucleotide polymorphism (SNP) in the GJA4 gene, coding for connexin37 (Cx37), with increased risk for atherosclerosis and myocardial infarction.
Cx37 deletion enhances vascular growth and facilitates ischemic limb recovery.
GeneRIF
Burt et al., Tucson, United States. In Am J Physiol Heart Circ Physiol, 2011
Results are consistent with Cx37 exerting a growth-suppressive effect in the vasculature that limits embryonic vasculogenesis as well as arteriogenic and angiogenic responses to ischemic injury in the adult animal.
Connexins participate in the initiation and progression of atherosclerosis.
Review
Kwak et al., Genève, Switzerland. In Semin Immunopathol, 2009
Four connexins are expressed in the vascular wall: Cx37, Cx40, Cx43, and Cx45.
Connexin37: a potential modifier gene of inflammatory disease.
Review
GeneRIF
Kwak et al., Genève, Switzerland. In J Mol Med (berl), 2007
Cx37 is expressed in the vascular endothelium as well as in monocytes and macrophages and these three cell types are key players in atherogenesis.
Connexin37 protects against atherosclerosis by regulating monocyte adhesion.
Impact
Kwak et al., Genève, Switzerland. In Nat Med, 2006
A genetic polymorphism in the human gene encoding connexin37 (CX37, encoded by GJA4, also known as CX37) has been reported as a potential prognostic marker for atherosclerosis.
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.
Impact
Yokota et al., Mitake, Japan. In N Engl J Med, 2003
In a large-scale study involving the selected polymorphisms and the remaining 4152 subjects, similar logistic-regression analysis revealed that the risk of myocardial infarction was significantly associated with the C1019T polymorphism in the connexin 37 gene (P<0.001) in men and the 4G-668/5G polymorphism in the plasminogen-activator inhibitor type 1 gene (P<0.001)
Immunocytochemical analysis of connexin expression in the healthy and diseased cardiovascular system.
Review
Halliday et al., London, United Kingdom. In Microsc Res Tech, 2001
In the major arteries, endothelial gap junctions may simultaneously express three connexin isotypes, connexin40, connexin37, and connexin43; underlying medial smooth muscle, by contrast, predominantly expresses connexin43, with connexin45 additionally expressed at restricted sites.
Female infertility in mice lacking connexin 37.
Impact
Paul et al., Boston, United States. In Nature, 1997
Here we show that connexin 37 is present in gap junctions between oocyte and granulosa cells and that connexin 37-deficient mice lack mature (Graafian) follicles, fail to ovulate and develop numerous inappropriate corpora lutea.
Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides.
Impact
Eisenbach et al., Israel. In Nat Med, 1995
We have recently isolated tumour-associated antigen (TAA) peptides, MUT 1 and MUT 2, derived from a mutated connexin 37 gap-junction protein, from the malignant 3LL-D122 murine lung carcinoma.
CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma.
Impact
Eisenbach et al., Israel. In Nature, 1994
Here we use total acid extraction and repeated fractionation to isolate and sequence Lewis lung carcinoma (3LL)-specific peptide(s), which shows sequence homology to the connexin 37 protein.
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