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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Gap junction protein, delta 2

Cx36, connexin36
component of gap junctions that may mediate cell-cell signaling that contributes to insulin cell function [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: GAP, V1a, CAN, Insulin, Connexin 43
Papers on Cx36
Mathematical modeling of gap junction coupling and electrical activity in human β-cells.
New
Pedersen et al., Roma, Italy. In Phys Biol, Dec 2015
Coordinated insulin secretion is controlled by electrical coupling of pancreatic β-cells due to connexin-36 gap junctions.
Expression and Localization of Connexins in the Outer Retina of the Mouse.
New
Janssen-Bienhold et al., Oldenburg, Germany. In J Mol Neurosci, Nov 2015
Using immunoelectron microscopy, we demonstrate that connexin36 (Cx36) is present in gap junctions of cone but not rod photoreceptors in the mouse retina.
Connexin36 expression in major centers of the auditory system in the CNS of mouse and rat: Evidence for neurons forming purely electrical synapses and morphologically mixed synapses.
New
Nagy et al., Pittsburgh, United States. In Neuroscience, Oct 2015
Electrical synapses formed by gap junctions composed of connexin36 (Cx36) are widely distributed in the mammalian central nervous system (CNS).
Characterization of connexin36 gap junctions in the human outer retina.
New
Völgyi et al., Budapest, Hungary. In Brain Struct Funct, Aug 2015
Expression of Cx36, -45, -50 and -57 have been described in many species but there is still a disconcerting paucity of information regarding the Cx makeup of human retinal GJs.
Circadian clock control of connexin36 phosphorylation in retinal photoreceptors of the CBA/CaJ mouse strain.
Ribelayga et al., Houston, United States. In Vis Neurosci, 2015
The gap-junction-forming protein connexin36 (Cx36) represents the anatomical substrate of photoreceptor electrical coupling in mammals.
Increased phosphorylation of Cx36 gap junctions in the AII amacrine cells of RD retina.
Sagdullaev et al., White Plains, United States. In Front Cell Neurosci, 2014
To test this, we evaluated the expression and phosphorylation state of connexin36 (Cx36), the gap junction subunit predominantly expressed in AII amacrine cells, in two mouse models of RD, rd10 (slow degeneration) and rd1 (fast degeneration).
KCl -Permeabilized Pancreatic Islets: An Experimental Model to Explore the Messenger Role of ATP in the Mechanism of Insulin Secretion.
Tamarit-Rodriguez et al., Madrid, Spain. In Plos One, 2014
Our previous work has demonstrated that islet depolarization with KCl opens connexin36 hemichannels in β-cells of mouse pancreatic islets allowing the exchange of small metabolites with the extracellular medium.
Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion.
Guo et al., Wuhan, China. In Sci Rep, 2014
Here, we found that chronic cerebral hypoperfusion resulted in rat hippocampal atrophy, neuronal apoptosis, enhancement and redistribution of autophagy, down-regulation of Bcl-2/Bax ratio, elevation of cleaved caspase-3 levels, reduction of surface expression of GABAA receptor α1 subunit and an increase in surface and mitochondrial expression of connexin 43 (CX43) and CX36.
New insights into the role of connexins in pancreatic islet function and diabetes.
Review
Benninger et al., Aurora, United States. In Febs Lett, 2014
β-cell specific coupling is established through gap junctions composed of connexin36, which results in coordinated insulin release across the islet.
Involvement of gap junction channels in the pathophysiology of migraine with aura.
Review
Mesnil et al., Poitiers, France. In Front Physiol, 2013
Quinine, quinidine and the derivative mefloquine are able to inhibit CSD suggesting an involvement of neuronal connexin36 channels in CSD propagation.
Impaired β-cell-β-cell coupling mediated by Cx36 gap junctions in prediabetic mice.
GeneRIF
Collares-Buzato et al., Campinas, Brazil. In Am J Physiol Endocrinol Metab, 2012
Data suggest that gap junction coupling of beta-cells mediated by Cx36 is impaired in prediabetic mice (induced along with obesity by high-fat diet); prediabetic mice exhibit decrease in islet Cx36 and glucose-stimulated insulin secretion.
Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse.
GeneRIF
Benninger et al., Nashville, United States. In Diabetes, 2012
It was concluded that connexin-36 gap junctions regulate the in vivo dynamics of insulin secretion, which is important for glucose homeostasis. Coordinated pulsatility of individual islets enhanced first-phase elevation and second-phase pulses of insulin.
Connexin 36 is expressed in beta and connexins 26 and 32 in acinar cells at the end of the secondary transition of mouse pancreatic development and increase during fetal and perinatal life.
GeneRIF
Pérez-Palacios et al., Mexico. In Anat Rec (hoboken), 2012
Connexin 36 is expressed in beta and connexins 26 and 32 in acinar cells at the end of the secondary transition of mouse pancreatic development and increase during fetal and perinatal life.
Regulation of connexin 36 expression during development.
GeneRIF
Belousov et al., Kansas City, United States. In Neurosci Lett, 2012
during development, acute activation of group II mGluRs causes up-regulation of Cx36 via post-transcriptional mechanisms
Synergy between electrical coupling and membrane properties promotes strong synchronization of neurons of the mesencephalic trigeminal nucleus.
GeneRIF
Pereda et al., Montevideo, Uruguay. In J Neurosci, 2012
Electrical transmission is supported by connexin36 (Cx36)-containing gap junctions at somato-somatic contacts of MesV neurons.
Cell-cell interactions in the endocrine pancreas.
Review
Lammert et al., Düsseldorf, Germany. In Diabetes Obes Metab, 2009
This review discusses how islet hormones, secreted molecules and ions influence the endocrine cells and how cell adhesion molecules such as neural cell adhesion molecule, cadherins, connexin-36, Eph receptors and ephrin ligands, as well as extracellular matrix proteins, modulate pancreatic islet function.
Connexin-dependent transcellular transcriptomic networks in mouse brain.
Review
Spray et al., New York City, United States. In Prog Biophys Mol Biol, 2007
We now report a remarkable overlap between regulations in Gja1(-/-) and connexin32 null (Gjb1(-/-)) brains, and that both differ markedly from those in connexin36 null (Gja9(-/-)) brain.
Electrical synapses--gap junctions in the brain.
Review
Dermietzel et al., Bochum, Germany. In Results Probl Cell Differ, 2005
With the cloning of connexin36 (Cx36), a connexin protein with predominantly neuronal expression, the biochemical correlate of electrotonic transmission between neurons was identified.
Electrical synapses in the mammalian brain.
Review
Impact
Long et al., Providence, United States. In Annu Rev Neurosci, 2003
All these synapses require the gap junction protein connexin36 (Cx36) for robust electrical coupling.
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