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BMP binding endothelial regulator

CV2, crossveinless 2, BMPER
This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: CRMP5, CAN, HAD, Amphiphysin, MM2
Papers on CV2
Pitfalls in the detection of CV2 (CRMP5) antibodies.
New
Graus et al., Barcelona, Spain. In J Neuroimmunol, Feb 2016
CV2 antibodies (CV2-ab) associate with paraneoplastic neurological syndromes (PNS) and small-cell lung cancer.
Determinants of rebound burst responses in rat cerebellar nuclear neurons to physiological stimuli.
New
Turner et al., Calgary, Canada. In J Physiol, Jan 2016
Similarly, neither complex spike firing nor Purkinje cell patterns identified by CV2 analysis were reliably associated with rebound bursts.
Associations between allelic polymorphism of the BMP Binding Endothelial Regulator and phenotypic variation of cattle.
New
Zan et al., China. In Mol Cell Probes, Dec 2015
The BMP Binding Endothelial Regulator (BMPER) is an inhibitor of bone morphogenetic proteins (BMPs), which play fundamental roles in adipocyte differentiation, fat development and energy balance.
Extending the phenotype of BMPER-related skeletal dysplasias to ischiospinal dysostosis.
New
Cho et al., Linköping, Sweden. In Orphanet J Rare Dis, Dec 2015
ISD is similar to, but milder than the lethal/semilethal condition termed diaphanospondylodysostosis (DSD), which is associated with homozygous or compound heterozygous mutations of bone morphogenetic protein-binding endothelial regulator protein (BMPER) gene.
BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis.
New
Lehman et al., Vancouver, Canada. In J Hum Genet, Dec 2015
Diaphanospondylodysostosis (DSD), caused by loss of bone morphogenetic protein-binding endothelial regulator (BMPER), has been considered a lethal skeletal dysplasia characterized by severe deficiency of vertebral body and sacral ossification, reduced rib number and cystic kidneys.
BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions.
Patterson et al., Chapel Hill, United States. In Plos One, 2014
Consistent with the role of the bone morphogenetic protein (BMP) signaling pathway in cardiac valve formation, embryos that are deficient for the BMP regulator BMPER (BMP-binding endothelial regulator) display the cardiac valve anomaly mitral valve prolapse.
[EFFECT OF PEPTIDE SEMAX ON SYNAPTIC ACTIVITY AND SHORT-TERM PLASTICITY OF GLUTAMATERGIC SYNAPSES OF CO-CULTURED DORSAL ROOT GANGLION AND DORSAL HORN NEURONS].
Fedulova et al., In Fiziol Zh, 2014
Also Semax (10 and 100 µM) induces changes of the basic parameters of short-term plasticity in sensory synapses: (1) increasing the paired-pulse ratio from 0.53 ± 0.028 (n = 8) to 0.91 ± 0.072 (n = 6, P < 0.01) and 0.95 ± 0.026 (n = 7; P < 0.001); (2) reducing the ratio of the coefficients of variation (CV2/ CV1) from 1.49 ± 0.11 (n = 8) to 1.02 ± 0.09 (n = 6; P < 0.05) and 1.11 ± 0.13 (n = 7; P < 0.0) respectively.
Spatio-Temporal Gene Expression Profiling during In Vivo Early Ovarian Folliculogenesis: Integrated Transcriptomic Study and Molecular Signature of Early Follicular Growth.
Mandon-Pepin et al., France. In Plos One, 2014
The expression of genes such as Kruppel-like factor 9 (KLF9) and BMP binding endothelial regulator (BMPER) was highlighted for the first time during early follicular development, and their proteins were also predicted to be involved in gene regulation.
Methylation-mediated BMPER expression in fibroblast activation in vitro and lung fibrosis in mice in vivo.
Jiang et al., Beijing, China. In Sci Rep, 2014
Here we identified BMP endothelial cell precursor-derived regulator (BMPER) as a key regulator of fibroblast activation.
Paraneoplastic disorders of the peripheral nervous system.
Review
Camdessanché et al., Saint-Étienne, France. In Presse Med, 2013
With solid tumour, antibodies directed to intracellular (anti-Hu or anti-CV2/CRMP5 antibodies) or surface antigens (anti-VGCC,or LGI1 and Caspr2 antibodies) have been identified while with lymphoma, the neuropathy is usually linked to a monoclonal gammopathy.
Antibody testing in peripheral nerve disorders.
Review
Graus et al., Basel, Switzerland. In Handb Clin Neurol, 2012
Anti-onconeural anti-Hu and anti-CV2/CRMP antibodies allow when they are detected the diagnosis of paraneoplastic neuropathies.
Paraneoplastic neurological syndromes.
Review
Dalmau et al., Barcelona, Spain. In Curr Opin Neurol, 2012
Isolated myelopathy may have a paraneoplastic origin associated with amphiphysin or CV2 (CRMP5) antibodies.
Paraneoplastic neuropathy.
Review
Sobue et al., Nagoya, Japan. In Handb Clin Neurol, 2012
Various onconeural antibodies, including anti-Hu, anti-CV2/CRMP-5, and anti-ganglionic acetylcholine receptor antibodies, are associated with neuropathy.
Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER).
GeneRIF
Rikitake et al., Kōbe, Japan. In J Biol Chem, 2012
BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs.
Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis.
GeneRIF
Patterson et al., Chapel Hill, United States. In Arterioscler Thromb Vasc Biol, 2012
Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis.
LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.
GeneRIF
Patterson et al., Chapel Hill, United States. In Circ Res, 2012
LRP1 acts as an endocytic receptor for Bmper and a coreceptor of Bmp4 to mediate the endocytosis of the Bmper/Bmp4 signaling complex.
Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium.
GeneRIF
Boström et al., Los Angeles, United States. In Blood, 2012
Mutual regulation by BMP-9 and CV2 is essential in regulating the development of the vascular endothelium.
BMPER protein is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice.
GeneRIF
McKie et al., London, United Kingdom. In J Biol Chem, 2012
Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice.
[Recent changes in the paradigm of limbic encephalitis].
Review
Illés, Pécs, Hungary. In Ideggyogy Sz, 2011
In contrast, the rare classical onconeural antibodies reacting with intracellular targets (anti-Hu, anti-Ta/Ma2, anti-CV2/CRMP5) may elicit additional symptoms beside limbic encephalitis and the prognosis of such syndromes is poor.
Host-parasitoid associations in patchy environments.
Impact
May et al., United States. In Nature, 1990
This 'CV2 greater than 1 rule' states that the overall population densities will remain roughly steady from generation to generation if the coefficient of variation squared (CV2) of the density of searching parasitoids in the vicinity of each host exceeds approximately unity.
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