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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Chromosome 10 open reading frame 46

Cullin, Cul1, Cullin-1
Encodes a cullin that is a component of SCF ubiquitin ligase complexes involved in mediating responses to auxin and jasmonic acid. Homozygous auxin-resistant mutants arrest growth soon after germination, lacking a root and hypocotyl. Heterozygotes display a variety of phenotypes consistent with impaired auxin response. (from NCBI)
Top mentioned proteins: Ubiquitin, SCF, Skp1, NEDD8, CAN
Papers on Cullin
The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart.
New
Wang et al., Guangzhou, China. In Autophagy, Feb 2016
UNASSIGNED: We demonstrated for the first time that the COP9 signalosome (COPS) controls the degradation of a surrogate and a bona fide misfolded protein in the cytosol of cardiomyocytes likely via supporting ubiquitination by CUL/cullin-RING ligases, and that Cops8 hypomorphism exacerbates cardiac proteinopathy in mice, in which autophagic impairment appears to be in play.
Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway.
New
Qiu et al., Yancheng, China. In Br J Cancer, Feb 2016
BACKGROUND: Regulator of cullins-1 (ROC1) is a key subunit in the cullin-RING ligase (CRL) protein complex.
KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.
New
Xiong et al., Shanghai, China. In Oncogene, Feb 2016
Here, we report that KDM2B, via its F-box domain, functions as a subunit of the CUL1-RING ubiquitin ligase (CRL1/SCF(KDM2B)) complex.
MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication.
New
Lou et al., Rochester, United States. In Cell Cycle, Feb 2016
In this study, we report that MMSET is degraded during S phase in a cullin-ring ligase 4-Cdt2 (CRL4(Cdt2)) and proteasome-dependent manner.
A mechanism for the suppression of homologous recombination in G1 cells.
New
Impact
Durocher et al., Toronto, Canada. In Nature, Jan 2016
We found that the BRCA1-interaction site on PALB2 is targeted by an E3 ubiquitin ligase composed of KEAP1, a PALB2-interacting protein, in complex with cullin-3 (CUL3)-RBX1 (ref.
CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.
New
Urushitani et al., Kyoto, Japan. In Sci Rep, Dec 2015
Here we identified a cullin-2 (CUL2) RING complex as a novel ubiquitin ligase for fragmented forms of TDP-43.
Revisiting Apoplastic Auxin Signaling Mediated by AUXIN BINDING PROTEIN 1.
Review
New
Kim et al., Chinju, South Korea. In Mol Cells, Dec 2015
It has been suggested that AUXIN BINDING PROTEIN 1 (ABP1) functions as an apoplastic auxin receptor, and is known to be involved in the post-transcriptional process, and largely independent of the already well-known SKP-cullin-F-box-transport inhibitor response (TIR1) /auxin signaling F-box (AFB) (SCF(TIR1/AFB)) pathway.
The role of cullin proteins in gastric cancer.
Review
New
Yao et al., Hohhot, China. In Tumour Biol, Nov 2015
There are seven cullin proteins that have been identified in eukaryotes: CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, and CUL7/p53-associated parkin-like cytoplasmic protein.
MicroRNA regulation of F-box proteins and its role in cancer.
Review
New
Pfeffer et al., Memphis, United States. In Semin Cancer Biol, Nov 2015
F-box proteins function as the substrate-recognition components of the SKP1-CUL1-F-box (SCF)-ubiquitin ligase complex for the degradation of their protein targets by the ubiquitin-proteasome system.
Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.
Review
New
Sutherland et al., Dundee, United Kingdom. In Biochem Soc Trans, Sep 2015
In the former case, oxidants/electrophiles increase the stability of Nrf2 by antagonizing the ability of Kelch-like ECH-associated protein 1 (Keap1) to target the transcription factor for proteasomal degradation via the cullin-3 (Cul3)-RING ubiquitin ligase CRL(Keap1).
Protein neddylation: beyond cullin-RING ligases.
Review
Impact
Peter et al., Zürich, Switzerland. In Nat Rev Mol Cell Biol, 2015
NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin-RING ligases.
Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.
Impact
Bassermann et al., München, Germany. In Nat Med, 2014
FBXO25 encodes an orphan F-box protein that determines the substrate specificity of the SCF (SKP1-CUL1-F-box)(FBXO25) ubiquitin ligase complex.
The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair.
Review
Dellaire et al., Halifax, Canada. In Biomolecules, 2014
Of interest is the COP9 signalosome (CSN), a multi-subunit metalloprotease present in eukaryotes that removes NEDD8 from cullins and regulates the activity of cullin-RING ubiquitin ligases (CRLs).
SCF ubiquitin ligase-targeted therapies.
Review
Impact
Pagano et al., New York City, United States. In Nat Rev Drug Discov, 2014
F-box proteins are the substrate-targeting subunits of SKP1-CUL1-F-box protein (SCF) ubiquitin ligase complexes.
Molecular architecture and mechanism of the anaphase-promoting complex.
Impact
Barford et al., London, United Kingdom. In Nature, 2014
The APC/C is an unusually large multimeric cullin-RING ligase.
Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.
GeneRIF
Deshaies et al., Pasadena, United States. In J Biol Chem, 2012
Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.
Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.
GeneRIF
Schulman et al., Memphis, United States. In Mol Cell, 2012
RBX1-containing cullin-RING ligases can bind glomulin (GLMN), which binds RING-box1's RING domain, regulating the RBX1-CUL1-containing SCF(FBW7) complex.
The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.
GeneRIF
DeCaprio et al., Boston, United States. In Mol Cell, 2012
Glomulin binds Rbx1 and regulates cullin-1 RING ligase-mediated turnover of Fbw7.
Characterization of the Cullin7 E3 ubiquitin ligase--heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity.
GeneRIF
Hagen et al., Singapore, Singapore. In Cell Signal, 2012
binding of Cul1-Rbx1 to Cul7-Rbx1 is mediated via heterodimerization of Fbxw8 with other F-box proteins which function to recruit substrates into the E3 ligase complex
Association of Cullin1 haplotype variants with rheumatoid arthritis and response to methotrexate.
GeneRIF
Juyal et al., In Pharmacogenet Genomics, 2011
Association with CUL1 haplotype indicates a possible role of CUL1 variation(s) in rheumatoid arthritis and its response to methotrexate.
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