The role of cullin proteins in gastric cancer.
Hohhot, China. In Tumour Biol, Nov 2015
There are seven cullin proteins that have been identified in eukaryotes: CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, and CUL7/p53-associated parkin-like cytoplasmic protein.
New insights into the mechanism for VACM-1/cul5 expression in vascular tissue in vivo.
Holland, United States. In Int Rev Cell Mol Biol, 2013
Vasopressin-activated calcium-mobilizing (VACM-1)/cul5 is the least conserved member of a cullin protein family involved in the formation of E3-specific ligase complexes that are responsible for delivering the ubiquitin protein to their target substrate proteins selected for ubiquitin-dependent degradation.
Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.
San Francisco, United States. In Nature, 2012
The AIDS virus, human immunodeficiency virus type 1 (HIV-1), produces the accessory factor Vif, which counteracts the host's antiviral defence by hijacking a ubiquitin ligase complex, containing CUL5, ELOC, ELOB and a RING-box protein, and targeting APOBEC3G for degradation.
Mutational analysis of VACM-1/cul5 exons in cancer cell lines.
Holland, United States. In Apmis, 2011
study showed VACM-1 DNA in T47D cancer cells is not mutated; SNP found in U138MG, OVCAR-3 and ACHN cell lines results in silent mutation; results suggest in T47D cancer cells, VACM-1 activity may controlled by epigenetic or posttranslational modification