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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cullin 2

Cul2, cullin 2
encodes an Arabidopsis cullin (from NCBI)
Top mentioned proteins: Ubiquitin, Cullin, VHL, CAN, Rbx1
Papers on Cul2
Regulation of glucose metabolism by p62/SQSTM1 through HIF1α.
New
Ye et al., Wuhan, China. In J Cell Sci, Feb 2016
Expression of p62 inhibits the DCNL1-CUL2 interaction and attenuates the neddylation of CUL2, and thus downregulates the VHL E3 ligase complex activity.
Association between cell cycle gene transcription and tumor size in oral squamous cell carcinoma.
New
Gomez et al., Belo Horizonte, Brazil. In Tumour Biol, Dec 2015
Among these genes, 13 reached statistical significance: ANAPC4, CUL1, SUMO1, KPNA2, MAD2L2, CCNG2, E2F4, NBN, CUL2, PCNA, TFDP1, KNTC1, and ATR.
CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.
New
Urushitani et al., Kyoto, Japan. In Sci Rep, Dec 2015
Here we identified a cullin-2 (CUL2) RING complex as a novel ubiquitin ligase for fragmented forms of TDP-43.
Socs36E limits STAT signaling via Cullin2 and a SOCS-box independent mechanism in the Drosophila egg chamber.
New
Starz-Gaiano et al., Baltimore, United States. In Mech Dev, Nov 2015
We found that Socs36E genetically interacts with the Cullin2 (Cul2) scaffolding protein.
The role of cullin proteins in gastric cancer.
Review
New
Yao et al., Hohhot, China. In Tumour Biol, Nov 2015
There are seven cullin proteins that have been identified in eukaryotes: CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, and CUL7/p53-associated parkin-like cytoplasmic protein.
Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex.
New
Xiong et al., New Haven, United States. In Structure, Apr 2015
The von Hippel-Lindau tumor suppressor protein (VHL) recruits a Cullin 2 (Cul2) E3 ubiquitin ligase to downregulate HIF-1α, an essential transcription factor for the hypoxia response.
UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation.
GeneRIF
Alexandru et al., Dundee, United Kingdom. In Bmc Biol, 2011
Study finds that UBXN7 over-expression converts CUL2 to its neddylated form and causes the accumulation of non-ubiquitylated HIF1alpha.
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Impact
Daly et al., Boston, United States. In Nat Genet, 2011
Through follow-up genotyping of 70 rare and low-frequency protein-altering variants in nine independent case-control series (16,054 Crohn's disease cases, 12,153 ulcerative colitis cases and 17,575 healthy controls), we identified four additional independent risk factors in NOD2, two additional protective variants in IL23R, a highly significant association with a protective splice variant in CARD9 (P < 1 × 10(-16), odds ratio ≈ 0.29) and additional associations with coding variants in IL18RAP, CUL2, C1orf106, PTPN22 and MUC19.
The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.
GeneRIF
Stunnenberg et al., Nijmegen, Netherlands. In Embo J, 2011
The authors applied protein-complex purification strategies and identified PRAME as a substrate recognition subunit of a Cullin2-based E3 ubiquitin ligase.
Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers.
GeneRIF
Lee et al., Seoul, South Korea. In Apmis, 2009
The data suggest that neither HIF1alpha nor CUL2 mutation may play a central role in HIF1alpha activation in gastric, colorectal, breast, lung and hepatocellular carcinomas, and acute leukemias.
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
Impact
Deshaies et al., Pasadena, United States. In Cell, 2008
In particular, UBXD7 links p97 to the ubiquitin ligase CUL2/VHL and its substrate hypoxia-inducible factor 1alpha (HIF1alpha).
CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis.
GeneRIF
Whitsett et al., Cincinnati, United States. In J Biol Chem, 2008
CUL2 is required for normal vasculogenesis, at least in part mediated by its regulation of HIF-mediated transcription.
Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor.
GeneRIF
Munger et al., Boston, United States. In J Virol, 2007
the HPV16 E7-associated cullin 2 ubiquitin ligase complex contributes to aberrant degradation of the pRB tumor suppressor in HPV16 E7-expressing cells.
COMMD proteins and the control of the NF kappa B pathway.
Review
Burstein et al., Ann Arbor, United States. In Cell Cycle, 2007
COMMD1 binds to a multimeric ubiquitin ligase containing Elongins B/C, Cul2 and SOCS1 (ECS( SOCS1)).
A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin.
Review
Tyers et al., Toronto, Canada. In Biochim Biophys Acta, 2004
A plethora of other processes in development and disease are controlled by other SCF-like complexes, including those based on Cul2-SOCS-box adaptor protein and Cul3-BTB domain adaptor protein combinations.
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.
Impact
Xiong et al., Chapel Hill, United States. In Nat Cell Biol, 2004
Here, we report that human UV-damaged DNA-binding protein DDB1 associates stoichiometrically with CUL4A in vivo, and binds to an amino-terminal region in CUL4A in a manner analogous to SKP1, SOCS and BTB binding to CUL1, CUL2 and CUL3, respectively.
The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma.
Review
Ohh et al., Toronto, Canada. In Am J Physiol Renal Physiol, 2004
VHL protein (pVHL) is part of an E3 ubiquitin ligase complex called VEC that is composed of elongin B, elongin C, cullin 2, NEDD8, and Rbx1.
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.
Review
Peter et al., Zürich, Switzerland. In Embo J, 2004
The SCF (Skp1-Cul1-F-box) and ECS (ElonginC-Cul2-SOCS box) complexes are so far the best-characterized cullin-based ligases.
The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.
Impact
Peter et al., Zürich, Switzerland. In Nature, 2003
The SCF (Skp1-Cul1-F-box) and ECS (Elongin C-Cul2-SOCS box) complexes are two well-defined cullin-based E3-ligases.
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
Impact
Harper et al., Houston, United States. In Nature, 2003
Similarly, Cul2 and Cul5 interact with BC-box-containing specificity factors through the Skp1-like protein elongin C. Cul3 is required for embryonic development in mammals and Caenorhabditis elegans but its specificity module is unknown.
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