gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

CUE domain containing 2

CUEDC2, CUE domain containing 2
Top mentioned proteins: Ubiquitin, APC, V1a, IL-4, STAT3
Papers on CUEDC2
CUEDC2 Protects Against Experimental Colitis and Suppresses Excessive Proliferation of Intestinal Mucosa.
New
Cui et al., Beijing, China. In Dig Dis Sci, Dec 2015
BACKGROUND: CUEDC2, a CUE domain-containing protein, is highly expressed in many tumors, which also may be associated with inflammation.
Sinomenine inhibits breast cancer cell invasion and migration by suppressing NF-κB activation mediated by IL-4/miR-324-5p/CUEDC2 axis.
New
Zan et al., Xi'an, China. In Biochem Biophys Res Commun, Sep 2015
Western blotting and ELISA approaches indicated that the suppression effect was closely associated with the phosphorylation of IκB kinase (IKK) and its negative regulator CUEDC2.
CUEDC2 down-regulation is associated with tumor growth and poor prognosis in lung adenocarcinoma.
New
Xie et al., Guangzhou, China. In Oncotarget, Sep 2015
CUE domain-containing 2 (CUEDC2) is a multi-functional protein, which regulates cell cycle, growth factor signaling and inflammation.
Overexpression of CUEDC2 Predicts Poor Prognosis in Ovarian Serous Carcinomas.
Liu et al., Beijing, China. In J Cancer, 2014
CUEDC2, a newly reported protein, plays critical roles in many biological processes, such as cell cycle, inflammation and tumorigenesis, however, its expression in ovarian serious carcinoma is still poorly understood.
Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer.
Li et al., Linfen, China. In Cell Rep, 2014
CUEDC2, a CUE-domain-containing protein, modulates inflammation, but its involvement in tumorigenesis is still poorly understood.
CUEDC2 interacts with heat shock protein 70 and negatively regulates its chaperone activity.
Chen et al., Beijing, China. In Biochem Biophys Res Commun, 2014
Recently studies have revealed that CUEDC2, a CUE domain-containing protein, plays critical roles in many biological processes, such as cell cycle, inflammation and tumorigenesis.
CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment.
Pang et al., Tianjin, China. In Leuk Res, 2013
CUEDC2, a newly reported protein, has been found to be ubiquitously expressed in human tissues and repress NF-κB activity.
Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/C(Cdh1) regulation.
Li et al., Beijing, China. In Proc Natl Acad Sci U S A, 2013
Here, we have identified a critical role for CUE domain-containing protein 2 (CUEDC2) in this process.
CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling.
GeneRIF
Li et al., Beijing, China. In J Biol Chem, 2012
a new biological activity for CUEDC2 as the regulator of JAK1/STAT3 signaling and the mechanism by which SOCS3 has been linked to suppression of the JAK/STAT pathway
CUEDC2: an emerging key player in inflammation and tumorigenesis.
Review
Zhang et al., Beijing, China. In Protein Cell, 2011
CUE domain-containing 2 (CUEDC2) is a protein involved in the regulation of the cell cycle, inflammation, and tumorigenesis and is highly expressed in many types of tumors.
Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability.
Impact
GeneRIF
Zhang et al., Beijing, China. In Nat Cell Biol, 2011
CUEDC2 is a cell-cycle regulator that promotes spindle checkpoint inactivation and releases APC/C from checkpoint inhibition. CUEDC2 is phosphorylated by Cdk1 during mitosis.
Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer.
Impact
GeneRIF
Zhang et al., Beijing, China. In Nat Med, 2011
key factor in endocrine resistance in breast cancer
LNCaP Atlas: gene expression associated with in vivo progression to castration-recurrent prostate cancer.
Sadar et al., Vancouver, Canada. In Bmc Med Genomics, 2009
Expression profiles of genes in CRPC support a role for the transcriptional activity of the androgen receptor (CCNH, CUEDC2, FLNA, PSMA7), steroid synthesis and metabolism (DHCR24, DHRS7, ELOVL5, HSD17B4, OPRK1), neuroendocrine (ENO2, MAOA, OPRK1, S100A10, TRPM8), and proliferation (GAS5, GNB2L1, MT-ND3, NKX3-1, PCGEM1, PTGFR, STEAP1, TMEM30A), but neither supported nor discounted a role for cell survival genes.
Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1.
Impact
Zhang et al., Beijing, China. In Nat Immunol, 2008
Here we demonstrate that CUE domain-containing 2 (CUEDC2) interacted with IKKalpha and IKKbeta and repressed activation of the transcription factor NF-kappaB by decreasing phosphorylation and activation of IKK.
CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome.
GeneRIF
Zhang et al., Beijing, China. In Embo J, 2007
These results identify a key post-translational mechanism that controls progesterone receptor protein levels and for the first time provide an important insight into the function of CUEDC2 in breast cancer proliferation.
share on facebooktweetadd +1mail to friends