Characterization of the Pharmacokinetics-Pharmacodynamics of Tazobactam in Combination with Piperacillin in an In Vitro Infection Model.
Oxford, United Kingdom. In Antimicrob Agents Chemother, Feb 2016
Using an in vitro infection model and the same isogenic CTX-M-15-producing Escherichia coli triplet set genetically engineered to transcribe different levels of blaCTX-M-15, herein we describe dose-fractionation studies designed to evaluate the PK-PD measure associated with tazobactam efficacy, when given in combination with piperacillin, and the impact of the presence of a different β-lactam agent, or different blaCTX-M-15 transcription levels, on the magnitude of the tazobactam PK-PD measure necessary for efficacy.
Anti-sclerostin - is there an indication?
Uppsala, Sweden. In Injury, Jan 2016
Biochemical markers revealed a transitory increase in the bone formation marker P1NP while no change in the bone resorption marker β-CTX.
Single nucleotide polymorphisms in the vitamin D pathway associating with circulating concentrations of vitamin D metabolites and non-skeletal health outcomes: Review of genetic association studies.
London, United Kingdom. In J Steroid Biochem Mol Biol, Jan 2016
We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D).
Mitochondrial regulation of macrophage cholesterol homeostasis.
Glasgow, United Kingdom. In Free Radic Biol Med, Dec 2015
Mitochondrial sterol 27-hydroxylase (CYP27A1) can generate oxysterol activators of liver X receptors which heterodimerise with retinoid X receptors, enhancing the transcription of ATP binding cassette transporters (ABCA1, ABCG1, and ABCG4), that can remove excess cholesterol via efflux to apolipoproteins A-1, E, and high density lipoprotein, and inhibit inflammation.
Breast cancer and (25R)-26-hydroxycholesterol.
United States. In Steroids, Dec 2015
Although most tissues express CYP27A1, the highest levels are in macrophages and most attention had been given to the production of 27-hydroxycholesterol in sub-endothelial macrophages as part of reverse cholesterol transport.