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Cytochrome P450, family 27, subfamily A, polypeptide 1

CTX, CYP27A1, sterol 27-hydroxylase
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, ACID, CAN, fibrillin-1, POLYMERASE
Papers on CTX
Characterization of the Pharmacokinetics-Pharmacodynamics of Tazobactam in Combination with Piperacillin in an In Vitro Infection Model.
Ambrose et al., Oxford, United Kingdom. In Antimicrob Agents Chemother, Feb 2016
Using an in vitro infection model and the same isogenic CTX-M-15-producing Escherichia coli triplet set genetically engineered to transcribe different levels of blaCTX-M-15, herein we describe dose-fractionation studies designed to evaluate the PK-PD measure associated with tazobactam efficacy, when given in combination with piperacillin, and the impact of the presence of a different β-lactam agent, or different blaCTX-M-15 transcription levels, on the magnitude of the tazobactam PK-PD measure necessary for efficacy.
Taiwan cobra cardiotoxin III suppresses EGF/EGFR-mediated epithelial-to-mesenchymal transition and invasion of human breast cancer MDA-MB-231 cells.
Lin et al., Kao-hsiung, Taiwan. In Toxicon, Feb 2016
CTX III, a basic polypeptide isolated from Naja naja atra venom, has been shown to exhibit anticancer activity; however, the effect of CTX III on the EMT of cancer cells remains elusive.
Elevated levels of Interleukin (IL)-33 induce bone pathology but absence of IL-33 does not negatively impact normal bone homeostasis.
Benschop et al., Indianapolis, United States. In Cytokine, Feb 2016
Furthermore, the detrimental bone effects were accompanied by increases in osteoclast number and the bone resorption marker of C-terminal telopeptide collagen-I (CTX-I).
Anti-sclerostin - is there an indication?
Larsson, Uppsala, Sweden. In Injury, Jan 2016
Biochemical markers revealed a transitory increase in the bone formation marker P1NP while no change in the bone resorption marker β-CTX.
Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria.
Thudium et al., Denmark. In Osteoarthritis Cartilage, Jan 2016
Amongst those were previously tested biomarkers such as osteocalcin, Carboxy-terminal cross-linked fragment of type II collagen (CTX-II) and cartilage oligomeric matrix protein (COMP).
Single nucleotide polymorphisms in the vitamin D pathway associating with circulating concentrations of vitamin D metabolites and non-skeletal health outcomes: Review of genetic association studies.
Martineau et al., London, United Kingdom. In J Steroid Biochem Mol Biol, Jan 2016
We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D).
Mitochondrial regulation of macrophage cholesterol homeostasis.
Graham, Glasgow, United Kingdom. In Free Radic Biol Med, Dec 2015
Mitochondrial sterol 27-hydroxylase (CYP27A1) can generate oxysterol activators of liver X receptors which heterodimerise with retinoid X receptors, enhancing the transcription of ATP binding cassette transporters (ABCA1, ABCG1, and ABCG4), that can remove excess cholesterol via efflux to apolipoproteins A-1, E, and high density lipoprotein, and inhibit inflammation.
Breast cancer and (25R)-26-hydroxycholesterol.
Javitt, United States. In Steroids, Dec 2015
Although most tissues express CYP27A1, the highest levels are in macrophages and most attention had been given to the production of 27-hydroxycholesterol in sub-endothelial macrophages as part of reverse cholesterol transport.
Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses.
Allen et al., Glasgow, United Kingdom. In World J Cardiol, Jun 2015
Macrophage generation of oxysterol activators of liver X receptors (LXRs), via sterol 27-hydroxylase, is regulated by the rate of flux of cholesterol to the inner mitochondrial membrane, via a complex of cholesterol trafficking proteins.
DC targeting DNA vaccines induce protective and therapeutic antitumor immunity in mice.
Zhao et al., Shanghai, China. In Int J Clin Exp Med, 2014
The existing tumors were eradicated by treatment with scFv(N418)-HER2 combined with low-dose cyclophosphamide (CTX), which can make a temporary regulatory T cells (Treg) depletion.
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.
McDonnell et al., Durham, United States. In Science, 2013
The effects of cholesterol on tumor pathology required its conversion to 27HC by the cytochrome P450 oxidase CYP27A1 and were attenuated by treatment with CYP27A1 inhibitors.
Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis.
Pikuleva et al., Cleveland, United States. In J Clin Invest, 2012
Loss of CYP27A1 led to dysregulation of retinal cholesterol homeostasis, including unexpected upregulation of retinal cholesterol biosynthesis. Cyp27a1-/- mice developed retinal lesions with cholesterol deposition beneath the retinal pigment epithelium.
Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.
Pikuleva et al., Cleveland, United States. In Arch Biochem Biophys, 2012
Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.
Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells.
Rodrigues et al., Lisbon, Portugal. In Neurochem Int, 2012
An alternative to elimination of brain cholesterol by the CYP46A1 mechanism is elimination by CYP27A1.
Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS.
Veldink et al., Utrecht, Netherlands. In Plos One, 2011
This study has identified candidate genes for sporadic Amyotrophic lateral sclerosis( ALS), most notably CYP27A1. Mutations in CYP27A1 are causal to cerebrotendinous xanthomatosis which can present as a clinical mimic of ALS .
2 Novel deletions of the sterol 27-hydroxylase gene in a Chinese Family with Cerebrotendinous Xanthomatosis.
Zhang et al., Beijing, China. In Bmc Neurol, 2010
CYP27A1 mutations were found in the proband and a Chinese family with Cerebrotendinous Xanthomatosis
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.
Mangelsdorf et al., Dallas, United States. In Cell, 2006
Interestingly, DAF-9 has a biochemical activity similar to mammalian CYP27A1 catalyzing addition of a terminal acid to the side chain of sterol metabolites.
Filamentous phage integration requires the host recombinases XerC and XerD.
Waldor et al., Boston, United States. In Nature, 2002
CTX phi is a filamentous bacteriophage that contains the genes encoding cholera toxin, the principal virulence factor of the diarrhoea-causing Gram-negative bacterium Vibrio cholerae.
Clinical impact of germ cell tumor cells in apheresis products of patients receiving high-dose chemotherapy.
Looijenga et al., Tübingen, Germany. In J Clin Oncol, 2001
PURPOSE: High-dose chemotherapy (HD-Ctx) followed by autologous peripheral-blood stem-cell (PBSC) transplantation is currently investigated in patients with poor prognosis or relapsed metastatic germ cell tumor (GCTs).
Comparative effects of three cytokine regimens after high-dose cyclophosphamide: granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor (GM-CSF), and sequential interleukin-3 and GM-CSF.
Patrone et al., Genova, Italy. In J Clin Oncol, 1999
PURPOSE: To compare the toxicity and effects on hematologic recovery and circulating progenitor cell mobilization of three cytokine regimens administered after high-dose cyclophosphamide (HD-CTX; 6 g/m(2)), given as the first step of a high-dose sequential chemotherapy.
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