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SPANX family, member C

CTP-11, SPANX-C
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SSX2, NY-ESO-1, MAGE-1, OUT, POLYMERASE
Papers on CTP-11
Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.
Sato et al., Sapporo, Japan. In Tissue Antigens, 2013
Eighteen genes (MAGEA2, MAGEA3, MAGEA4, MAGEA6, MAGEA12, MAGEB2, GAGE1, GAGE8, SPANXA1, SPANXB1, SPANXC, XAGE2, SPA17, BORIS, PLU-1, SGY-1, TEX15 and CT45A1) showed higher expression levels in SP cells than in MP cells, whereas 10 genes (BAGE1, BAGE2, BAGE4, BAGE5, XAGE1, LIP1, D40, HCA661, TDRD1 and TPTE) showed similar expression levels in SP cells and MP cells.
Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX in hepatocellular carcinoma.
Lee et al., Yangsan, South Korea. In Oncol Rep, 2012
We isolated 3 different antigens, AKAP3, CTp11, and UBQLN3.
Establishment and characterization of irinotecan-resistant human non-small cell lung cancer A549 cells.
Kolesar et al., Kagoshima, Japan. In Mol Med Report, 2010
Irinotecan (CTP-11) is a topoisomerase I inhibitor used in the treatment of colorectal cancer and non-small cell lung cancer (NSCLC).
Diagnostic value of cancer-testis antigen mRNA in peripheral blood from hepatocellular carcinoma patients.
Leng et al., Beijing, China. In World J Gastroenterol, 2010
Expression of melanoma antigen-1 (MAGE-1), synovial sarcoma X breakpoint-1 (SSX-1), and cancer-testis-associated protein of 11 kDa (CTp11) mRNA in peripheral blood mononuclear cells (PBMC) was tested by nested reverse transcripts-polymerase chain reaction (RT-PCR).
SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes.
GeneRIF
Bosco et al., Italy. In J Genet, 2009
SPANX-C gene dosage analysis in Down's syndrome subjects with undescended testes
SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Sicilian patients with melanoma.
GeneRIF
Rappazzo et al., Italy. In Melanoma Res, 2008
genetic variability of SPANX-B & SPANX-C in a sample of Sicilian male population including patients with cutaneous melanoma; statistical significant difference for a particular class of SPANX-C gene was found comparing patients with melanoma & controls
Mutational analysis of SPANX genes in families with X-linked prostate cancer.
Larionov et al., Bethesda, United States. In Prostate, 2007
The first cluster called SPANX-A/D includes SPANX-A1, SPANX-A2, SPANX-B, SPANX-C, and SPANX-D; the second cluster called SPANX-N includes SPANX-N1, SPANX-N2, SPANX-N3, and SPANX-N4.
Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis.
Herr et al., Charlottesville, United States. In Mol Hum Reprod, 2006
Human sperm protein associated with the nucleus on the X chromosome consists of a five-member gene family (SPANXA1, SPANXA2, SPANXB, SPANXC and SPANXD) clustered at Xq27.1.
A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region.
Bailey-Wilson et al., Philadelphia, United States. In Hum Genet, 2005
The two transcription units mapping within this interval are the LDOC1 and SPANXC genes.
The spontaneous CD8+ T-cell response to HLA-A2-restricted NY-ESO-1b peptide in hepatocellular carcinoma patients.
Chen et al., Beijing, China. In Clin Cancer Res, 2004
PURPOSE: Hepatocellular carcinoma (HCC) can express various cancer-testis antigens including NY-ESO-1, members of the SSX family, members of the MAGE family, SCP-1, and CTP11.
Expression of cancer-testis antigens in hepatocellular carcinoma.
Zhu et al., Beijing, China. In World J Gastroenterol, 2004
AIM: To investigate the expression of cancer-testis (CT) antigens MAGE-1, SSX-1,CTp11 and HCA587 genes in hepatocellular carcinoma (HCC) and the possibility of applying these antigens as targets for specific immunotherapy for HCC.
Expression of SPANX proteins in human-ejaculated spermatozoa and sperm precursors.
GeneRIF
Vicari et al., Catania, Italy. In Int J Androl, 2004
SPANXC was found in ejaculated spermatozoa and spermatids.
The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines.
van Muijen et al., Nijmegen, Netherlands. In Gene, 2003
In the present study we analyzed the number and expression of genes of the SPANX(CTp11) family of cancer/testis-associated genes.
[A case of esophageal small-cell carcinoma responding to chemotherapy with CTP-11].
Eriguchi et al., In Gan To Kagaku Ryoho, 2001
After examination of a 64-year-old man with dysphagia who consulted our hospital, a diagnosis was made an esophageal small-cell carcinoma.
NY-ESO-1 and CTp11 expression may correlate with stage of progression in melanoma.
Shih et al., New Brunswick, United States. In J Surg Res, 2001
One CT antigen, CTp11, was shown to be expressed by metastasizing melanoma cell lines but not by nonmetastasizing variants.
Topoisomerase I-DNA covalent complexes in human colorectal cancer xenografts with different p53 and microsatellite instability status: relation with their sensitivity to CTP-11.
Bailly et al., Lille, France. In Anticancer Res, 2001
The topoisomerase I poison CPT-11 has proved efficient for the treatment of untreated metastatic colorectal cancers (CRC) and those refractory to fluoropyrimidines.
New directions for chemotherapy in non-small-cell lung cancer.
Review
Green, San Diego, United States. In Chest, 1993
This article reviews available data for several of these agents: navelbine, which is an analogue of vinblastine, the camptothecins CTP-11 and topotecan, and taxol, the first of a novel class of antimicrotubule drugs.
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