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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

CTP synthase

CTP synthase
Top mentioned proteins: CAN, ACID, Glutaminase, V1a, STEP
Papers on CTP synthase
Regulation of CTP Synthase Filament Formation During DNA Endoreplication in Drosophila.
New
Pai et al., Taiwan. In Genetics, Dec 2015
CTP synthase (CTPsyn) plays an essential role in DNA, RNA, and lipid synthesis.
CTP Synthase Is Required for Optic Lobe Homeostasis in Drosophila.
New
Liu et al., Oxford, United Kingdom. In J Genet Genomics, Jun 2015
CTP synthase (CTPsyn) is a metabolic enzyme responsible for the de novo synthesis of the nucleotide CTP.
Single nucleotide resolution RNA-seq uncovers new regulatory mechanisms in the opportunistic pathogen Streptococcus agalactiae.
Glaser et al., Paris, France. In Bmc Genomics, 2014
In particular, 40% of the TSSs upstream genes involved in nucleotide metabolism show reiterative transcription potentially regulating gene expression, as exemplified for pyrG and thyA encoding the CTP synthase and the thymidylate synthase respectively.
Visualizing Cytoophidia Expression in Drosophila Follicle Cells via Immunohistochemistry.
Liu et al., Oxford, United Kingdom. In Methods Mol Biol, 2014
We describe a user-friendly immunohistochemical approach for the detection of protein localization in Drosophila ovaries, here focusing on CTP synthase.
Ack kinase regulates CTP synthase filaments during Drosophila oogenesis.
Peterson et al., Philadelphia, United States. In Embo Rep, 2014
The enzyme CTP synthase (CTPS) dynamically assembles into macromolecular filaments in bacteria, yeast, Drosophila, and mammalian cells, but the role of this morphological reorganization in regulating CTPS activity is controversial.
Common regulatory control of CTP synthase enzyme activity and filament formation.
Wilhelm et al., Nakhon Pathom, Thailand. In Mol Biol Cell, 2014
CTP synthase is an ideal model system for addressing this question because its activity is regulated via multiple mechanisms and its filament-forming ability is evolutionarily conserved.
CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation.
Impact
Latour et al., Paris, France. In Nature, 2014
CTP synthase activity is a potentially important step for DNA synthesis in lymphocytes.
Constitutive activation of the ATM/BRCA1 pathway prevents DNA damage-induced apoptosis in 5-azacytidine-resistant cell lines.
Ohyashiki et al., Tokyo, Japan. In Biochem Pharmacol, 2014
Furthermore, genes involved in pyrimidine metabolism were down-regulated in both AZA-resistant cell lines; AZA sensitivity was restored by inhibition of CTP synthase.
CTP synthase forms cytoophidia in the cytoplasm and nucleus.
Liu et al., Oxford, United Kingdom. In Exp Cell Res, 2014
CTP synthase is an essential metabolic enzyme responsible for the de novo synthesis of CTP.
Smooth muscle-specific drug targets for next-generation drug-eluting stent.
Review
Chen et al., Athens, United States. In Expert Rev Cardiovasc Ther, 2014
Our recent studies have shown that CTP synthase 1 (CTPS1) differentially regulates the proliferation of VSMC and EC after vascular injury.
Two-tiered biological containment strategy for Lactococcus lactis-based vaccine or immunotherapy vectors.
Gahan et al., Cork, Ireland. In Hum Vaccin Immunother, 2013
We show that a double mutation in the genes encoding ThyA and CTP synthase (PyrG) in L. lactis confers double auxotrophy for both thymidine and cytidine.
Asymmetric inheritance of cytoophidia in Schizosaccharomyces pombe.
Liu et al., Oxford, United Kingdom. In Biol Open, 2013
Here we show that CTP synthase, a metabolic enzyme responsible for the de novo synthesis of the nucleotide CTP, can form filamentous cytoophidia in the cytoplasm and nucleus of S. pombe cells.
Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and adaptive metabolism.
Liu et al., Oxford, United Kingdom. In Biol Open, 2013
The essential metabolic enzyme CTP synthase (CTPsyn) can be compartmentalised to form an evolutionarily-conserved intracellular structure termed the cytoophidium.
CTP synthase 1, a smooth muscle-sensitive therapeutic target for effective vascular repair.
Chen et al., Shiyan, China. In Arterioscler Thromb Vasc Biol, 2013
APPROACH AND RESULTS: Using both rat balloon injury and mouse wire injury models, we identified CTP synthase 1 (CTPS1) as one of the potential targets that may be used for developing therapeutics for treating neointima-related disorders.
The metabolic enzyme CTP synthase forms cytoskeletal filaments.
Impact
Gitai et al., Princeton, United States. In Nat Cell Biol, 2010
We demonstrate that the metabolic enzyme CTP synthase (CtpS) forms filaments in Caulobacter crescentus.
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