gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Thioesterase superfamily member 4

CTMP, Carboxyl-terminal modulator protein, C-Terminal Modulator Protein
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Akt, V1a, PI3K, Insulin, PrP
Papers on CTMP
Improving the hydrogen peroxide bleaching efficiency of aspen chemithermomechanical pulp by using chitosan.
New
Qin et al., Jinan, China. In Carbohydr Polym, Dec 2015
In this study, chitosans were used as peroxide stabilizer in the alkaline hydrogen peroxide bleaching of aspen chemithermomechanical pulp (CTMP).
The critical role of Akt in cardiovascular function.
Review
New
Su et al., Augusta, United States. In Vascul Pharmacol, Nov 2015
Protein-protein interactions of Akt to actin and Hsp90 increase the Akt activity while Akt binding to other proteins such as CTMP and TRB3 reduces the Akt activity.
From canonical to non-canonical cyclic nucleotides as second messengers: pharmacological implications.
Review
New
Bähre et al., Hannover, Germany. In Pharmacol Ther, Apr 2015
This review summarizes our knowledge on the non-canonical cyclic nucleotides cCMP, cUMP, cIMP, cXMP and cTMP.
Novel link of anti-apoptotic ATF3 with pro-apoptotic CTMP in the ischemic brain.
New
Lin et al., Taipei, Taiwan. In Mol Neurobiol, Apr 2015
As well, the protective effect of ATF3 was mediated by downregulation of carboxyl-terminal modulator protein (CTMP), a pro-apoptotic factor that inhibits the anti-apoptotic Akt/PKB cascade.
Sevoflurane preconditioning-induced neuroprotection is associated with Akt activation via carboxy-terminal modulator protein inhibition.
New
Xiong et al., Xi'an, China. In Br J Anaesth, Feb 2015
The aim of the present investigation was to evaluate whether sevoflurane-induced cerebral preconditioning involves inhibition of carboxy-terminal modulator protein (CTMP), an endogenous inhibitor of Akt, in a rat model of focal cerebral ischaemia.
High-fat diet reduces neuroprotection of isoflurane post-treatment: Role of carboxyl-terminal modulator protein-Akt signaling.
Zuo et al., Charlottesville, United States. In Obesity (silver Spring), 2014
OGD increased carboxyl-terminal modulator protein (CTMP), an Akt inhibitor, and decreased Akt signaling.
Small interfering RNA directed against CTMP reduces acute traumatic brain injury in a mouse model by activating Akt.
Zhao et al., In Neurol Res, 2014
The goal of this study is to investigate the effects of carboxyl-terminal modulator protein (CTMP) on phosphorylation of Akt and neurological function in a mouse model of TBI.
New players in high fat diet-induced obesity: LETM1 and CTMP.
Park et al., Cincinnati, United States. In Metabolism, 2014
C-terminal modulator protein (CTMP) and leucine zipper/EF-hand-containing transmembrane protein 1 (LETM1) have been reported to influence the phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB) signaling pathway via the modulation of PKB activity, a key player for insulin signaling.
Carboxyl-terminal modulator protein positively regulates Akt phosphorylation and acts as an oncogenic driver in breast cancer.
Lu et al., Taipei, Taiwan. In Cancer Res, 2013
In this study, we sought to clarify a regulatory role for the Akt-binding carboxy-terminal modulator protein (CTMP), which has been controversial.
Co-delivery of LETM1 and CTMP synergistically inhibits tumor growth in H-ras12V liver cancer model mice.
Cho et al., Seoul, South Korea. In Cancer Gene Ther, 2013
Successful self-cleavage of 2A-peptide induced synergistic antitumor effect in the liver of H-ras12V, the HCC model mice, by simultaneous activation of LETM1 (Leucine zipper/EF hand-containing transmembrane-1) and CTMP (carboxyl-terminal modulator protein).
cCMP, cUMP, cTMP, cIMP and cXMP as possible second messengers: development of a hypothesis based on studies with soluble guanylyl cyclase α(1)β(1).
Review
Seifert et al., Hannover, Germany. In Biol Chem, 2013
Adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate are second messengers that regulate multiple physiological functions.
Inhibition of the AKT/mTOR and erbB pathways by gefitinib, perifosine and analogs of gonadotropin-releasing hormone I and II to overcome tamoxifen resistance in breast cancer cells.
Günthert et al., Göttingen, Germany. In Int J Oncol, 2012
T47D-TR cells showed EGFR expression and activated MAPK (ERK-1/2), whereas in resistant MCF-7-TR cells activated AKT was due to loss of CTMP expression.
Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells.
GeneRIF
Cho et al., Seoul, South Korea. In Int J Oncol, 2012
Suggest that CTMP may therefore play a critical role in mitochondrial-mediated apoptosis in lung cancer cells.
Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation.
Kumar et al., New Delhi, India. In Febs J, 2012
The HBx-Akt interaction was essential for Akt signalling, and involved displacement of the Akt-bound negative regulator 'C-terminal modulator protein' by HBx.
The DNA methylome of pediatric acute lymphoblastic leukemia.
GeneRIF
Johansson et al., Lund, Sweden. In Hum Mol Genet, 2009
Data show low or moderate methylation was found in seven selected genes BAD, BBC3, CAV1, CDK2AP1, NPM1, PRKCDBP and THEM4.
Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis.
GeneRIF
Hemmings et al., Basel, Switzerland. In Cell Signal, 2009
Proper maturation of CTMP is essential for its pro-apoptotic function. CTMP delays PKB phosphorylation following cell death induction, suggesting that CTMP regulates apoptosis via inhibition of PKB.
Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein.
GeneRIF
Park et al., Taejŏn, South Korea. In Bmc Cell Biol, 2008
Phosphorylation on Ser37/Ser38 of CTMP is important for the prevention of mitochondrial localization of CTMP, eventually leading to cell death by binding to heat shock protein 70.
Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.
GeneRIF
Asano et al., Tokyo, Japan. In Am J Physiol Cell Physiol, 2007
CTMP induces translocation of Akt to the membrane and thereby increases the level of Akt phosphorylation. As a result, CTMP enhances various cellular activities that are principally mediated by the PI3-kinase/Akt pathway.
Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane.
Impact
Hemmings et al., Bellinzona, Switzerland. In Science, 2001
Here, we describe a protein partner for PKBalpha termed CTMP, or carboxyl-terminal modulator protein, that binds specifically to the carboxyl-terminal regulatory domain of PKBalpha at the plasma membrane.
[Preretinopathic changes in the oscillatory potential in diabetic retina: interpretation and significance].
Review
Kawasaki, Kanazawa, Japan. In Nihon Ganka Gakkai Zasshi, 1998
2) The peak latency and the amplitude of the OP are significantly correlated with the psychophysical contrast threshold for motion perception (CTMP) measured with our original device.
share on facebooktweetadd +1mail to friends