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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Solute carrier family 44, member 2

CTL2, Choline transporter-like protein 2, SLC44A2
Top mentioned proteins: CTL1, CAN, POLYMERASE, ACID, V1a
Papers on CTL2
Functional expression of choline transporter like-protein 1 (CTL1) and CTL2 in human brain microvascular endothelial cells.
Inazu et al., Tokyo, Japan. In Neurochem Int, Jan 2016
Choline transporter-like protein 1 (CTL1) and CTL2 mRNA were highly expressed, while mRNA for high-affinity choline transporter 1 (CHT1) and organic cation transporters (OCTs) were not expressed in hBMECs.
Characterization of choline transporters in the human placenta over gestation.
Winn et al., Aurora, United States. In Placenta, Dec 2015
RESULTS: Both CTL1 and CTL2 were expressed in the chorionic villi from 6 weeks gestation to term.
Identification of immunodominant antigens for the laboratory diagnosis of toxocariasis.
Hotez et al., Houston, United States. In Trop Med Int Health, Dec 2015
The first CTL (Tc-CTL-1) is the same as TES-32, previously identified as a major immunodominant component of TES; the second CTL (Tc-CTL-2) is a novel C-type lectin sharing 83% amino acid sequence identity within the functional domain of Tc-CTL-1.
Genotype frequency of human neutrophil antigen-3 polymorphisms in the Yi, Han, and Tibetan populations of China.
Flegel et al., Suzhou, China. In Transfusion, Dec 2015
Most frequencies of SLC44A2 alleles encoding the HNA-3a/b antigens have been established in Han individuals by polymerase chain reaction with sequence-specific priming (PCR-SSP).
Genetics of Venous Thrombosis: update in 2015.
Trégouët et al., Marseille, France. In Thromb Haemost, Dec 2015
To date, 17 genes have been robustly demonstrated to harbour genetic variations associated with VT risk: ABO, F2, F5, F9, F11, FGG, GP6, KNG1, PROC, PROCR, PROS1, SERPINC1, SLC44A2, STXBP5, THBD, TSPAN15 and VWF.
Hair Cell Loss, Spiral Ganglion Degeneration, and Progressive Sensorineural Hearing Loss in Mice with Targeted Deletion of Slc44a2/Ctl2.
Carey et al., Ann Arbor, United States. In J Assoc Res Otolaryngol, Nov 2015
UNASSIGNED: SLC44A2 (solute carrier 44a2), also known as CTL2 (choline transporter-like protein 2), is expressed in many supporting cell types in the cochlea and is implicated in hair cell survival and antibody-induced hearing loss.
Full-length nucleotide sequences of 30 common SLC44A2 alleles encoding human neutrophil antigen-3.
Flegel et al., Bethesda, United States. In Transfusion, Nov 2015
In this study, we determined the full-length nucleotide sequence of common SLC44A2 alleles encoding the choline transporter-like protein-2 that harbors HNA-3a/b antigens.
Choline Transporter-Like Protein-2: New von Willebrand Factor-Binding Partner Involved in Antibody-Mediated Neutrophil Activation and Transfusion-Related Acute Lung Injury.
Santoso et al., Kortrijk, Belgium. In Arterioscler Thromb Vasc Biol, Jul 2015
In a different context the target protein of these antibodies, choline transporter-like protein-2 (CTL-2), was reported to interact with a protein of the inner ear carrying 2 von Willebrand factor (VWF) A-domains.
Molecular and functional characterization of choline transporter in the human trophoblastic cell line JEG-3 cells.
Inazu et al., Tokyo, Japan. In Placenta, Jun 2015
The expression of CTL1 and CTL2 was evaluated by quantitative real-time PCR, western blotting and immunocytochemistry.
Catalases Induction in High Virulence Pinewood Nematode Bursaphelenchus xylophilus under Hydrogen Peroxide-Induced Stress.
Hasegawa et al., Kasugai, Japan. In Plos One, 2014
After 24 hours of exposure, high virulence isolates of B. xylophilus could withstand higher H2O2 concentrations in comparison with low virulence B. xylophilus and B. mucronatus, corroborating our observation of Bxy-ctl-1 and Bxy-ctl-2 catalase up-regulation under the same experimental conditions.
Spotlight on pathogenesis of TRALI: HNA-3a (CTL2) antibodies.
Shaz et al., In Blood, 2014
Human neutrophil antigen-3a (HNA-3a) antibodies contained in donor plasma can result in severe, sometimes fatal transfusion-related acute lung injury (TRALI).
The choline transporter-like family SLC44: properties and roles in human diseases.
Ruat et al., Gif-sur-Yvette, France. In Mol Aspects Med, 2013
SLC44A1 is widely expressed throughout the nervous system in both neurons and oligodendrocytes, while SLC44A2-4 are mainly detected in peripheral tissues.
Detection of HNA-3a and -3b antibodies using transfected cell lines and recombinant proteins.
Ridgwell et al., Bristol, United Kingdom. In Transfusion, 2012
HEK293 cells expressing full-length CTL2 proteins were useful in the detection of HNA-3 antibodies even in the presence of HLA antibodies.
Frequencies of SLC44A2 alleles encoding human neutrophil antigen-3 variants in the African American population.
Flegel et al., Bethesda, United States. In Transfusion, 2012
African Americans have a significantly lower probability of possessing the SLC44A2*2 allele and may thus be less likely to form the clinically relevant anti-HNA-3a.
Age-related changes in expression of CTL2/SLC44A2 and its isoforms in the mouse inner ear.
Carey et al., Ann Arbor, United States. In Hear Res, 2011
Report age related changes between the two isoforms of CTL2/SLC44A2 in the inner ear.
Developments in the definition and clinical impact of human neutrophil antigens.
Greinacher et al., Greifswald, Germany. In Curr Opin Hematol, 2011
RECENT FINDINGS: HNA-3 is localized on choline transporter-like protein 2 (CTL2) and originates from an Arg154Gln amino acid (aa) substitution.
Isoforms, expression, glycosylation, and tissue distribution of CTL2/SLC44A2.
Carey et al., Ann Arbor, United States. In Protein J, 2010
SLC44A2 P1 and P2 isoforms with differing glycosylation are variably expressed in cochlea, tongue, heart, colon, lung, kidney, liver and spleen suggesting tissue specific differences that may influence function in each tissue.
Characterization of the human neutrophil alloantigen-3a.
Bux et al., Greifswald, Germany. In Nat Med, 2010
SNP with arginine rather than glutamine at position 154 constitutes HNA-3a antigen and risk of transfusion-related acute lung injury (TRALI)
Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake.
Tamai et al., Kanazawa, Japan. In Biol Pharm Bull, 2009
In conclusion, choline transport in A549 cells is increased by treatment with DEX, and the increase is mediated by induction of functional choline transporters CTL1 and CTL2.
A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.
Chalfie et al., New York City, United States. In Nature, 1999
ctl-1 encodes an unusual cytosolic catalase; a second gene, ctl-2, encodes a peroxisomal catalase.
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