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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Collagen triple helix repeat containing 1

Cthrc1, collagen triple helix repeat containing 1
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: HAD, CAN, POLYMERASE, iMpact, fibrillin-1
Papers on Cthrc1
Diagnostic marker signature for esophageal cancer from transcriptome analysis.
New
Bollschweiler et al., Köln, Germany. In Tumour Biol, Jan 2016
The markers significantly overexpressed already in earlier tumor stages (pT1-2) of both histological subtypes (n = 19) have been clustered in a "diagnostic signature": PLA2G7, PRAME, MMP1, MMP3, MMP12, LIlRB2, TREM2, CHST2, IGFBP2, IGFBP7, KCNJ8, EMILIN2, CTHRC1, EMR2, WDR72, LPCAT1, COL4A2, CCL4, and SNX10.
Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication.
New
Wu et al., Wuhan, China. In J Mol Cell Biol, Dec 2015
We show that collagen triple helix repeat containing 1 (CTHRC1) expression is elevated in HBV-infected patients and in HBV-transfected cells through epigenetic modification and transcriptional regulation.
High expression of CTHRC1 promotes EMT of epithelial ovarian cancer (EOC) and is associated with poor prognosis.
New
Ke et al., Guangzhou, China. In Oncotarget, Dec 2015
Collagen triple helix repeat-containing 1 (CTHRC1) is aberrantly overexpressed in multiple malignant tumors.
Treatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease.
New
Ma et al., Shanghai, China. In J Autoimmun, Sep 2015
Collagen triple helix repeat containing-1 (Cthrc1) is a documented specific inhibitor of TGF-β signaling.
Cthrc1 controls adipose tissue formation, body composition, and physical activity.
New
Lindner et al., West Scarborough, United States. In Obesity (silver Spring), Aug 2015
OBJECTIVE: This study investigated the effects of loss of Cthrc1 on adipogenesis, body composition, metabolism, physical activity, and muscle physiology.
[Role of CTHRC1 in proliferation, migration and invasion of human colorectal cancer cells].
New
Li et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, May 2015
OBJECTIVE: To explore the expression of collagen triple helix repeat containing 1 (CTHRC1) in colorectal cancer and study its role in regulating the biological behaviors of colorectal cancer LoVo cells in vitro.
SP1-mediated microRNA-520d-5p suppresses tumor growth and metastasis in colorectal cancer by targeting CTHRC1.
Li et al., Guangzhou, China. In Am J Cancer Res, 2014
Dual-luciferase assays confirmed that miR-520d-5p directly targeting CTHRC1 and SP1 transactivate miR-520d-5p by binding to its upstream promoter region.
microRNA-30b inhibits cell invasion and migration through targeting collagen triple helix repeat containing 1 in non-small cell lung cancer.
Zhang et al., Zhengzhou, China. In Cancer Cell Int, 2014
RESULTS: MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues.
CTHRC1 promotes human colorectal cancer cell proliferation and invasiveness by activating Wnt/PCP signaling.
Li et al., Shanghai, China. In Int J Clin Exp Pathol, 2014
Collagen triple helix repeats containing 1 (CTHRC1) participates in vascular remodeling, bone formation, and developmental morphogenesis.
Collagen Triple Helix Repeat Containing-1 (CTHRC1) Expression in Oral Squamous Cell Carcinoma (OSCC): Prognostic Value and Clinico-Pathological Implications.
Zain et al., Kuala Lumpur, Malaysia. In Int J Med Sci, 2014
BACKGROUND: Collagen Triple Helix Repeat Containing 1 (CTHRC1) is a protein often found to be over-expressed in various types of human cancers.
The Crosstalk between Osteoclasts and Osteoblasts Is Dependent upon the Composition and Structure of Biphasic Calcium Phosphates.
Baron et al., Boston, United States. In Plos One, 2014
We found that BCPs with low percentage of HA favored the expression of positive coupling factors, including sphingosine-kinase 1 (SPHK1) and collagen triple helix repeat containing 1 (Cthrc1).
PRR11 Is a Prognostic Marker and Potential Oncogene in Patients with Gastric Cancer.
Hu et al., Chongqing, China. In Plos One, 2014
PRR11 was stably silenced in a gastric carcinoma cell line using an shRNA-based approach, and treated cells showed decreased cellular proliferation and colony formation in vitro and cell growth in vivo, companied by decreased expression of CTHRC1 and increased expression of LXN, proteins involved in tumor progression.
Hereditary Factors in Esophageal Adenocarcinoma.
Review
Wijnhoven et al., Rotterdam, Netherlands. In Gastrointest Tumors, 2014
However, some association has been found with (attenuated) familial adenomatous polyposis, mismatch repair deficiency and recently with the genes MSR1, ASCC1 and CTHRC1.
Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries.
GeneRIF
Lindner et al., West Scarborough, United States. In Genesis, 2011
Data show a dramatic discrepancy between ROSA26 reporter activity and Pdgfrb promoter driven Cre dependent myc-tagged Cthrc1 transgene expression.
Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma.
Impact
GeneRIF
Eng et al., Cleveland, United States. In Jama, 2011
Three major genes, MSR1, ASCC1, and CTHRC1 were associated with Barrett esophagus/esophageal adenocarcinoma
Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice.
GeneRIF
Keijer et al., Wageningen, Netherlands. In Carcinogenesis, 2010
Downregulated by dietary beta-carotene in lungs of knockout Bcmo1-deficient mice.
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
GeneRIF
Sasaki et al., Kōbe, Japan. In Dev Cell, 2008
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
Cthrc1 is a positive regulator of osteoblastic bone formation.
GeneRIF
Akiyama et al., Kyoto, Japan. In Plos One, 2007
Cthrc1 increases bone mass as a positive regulator of osteoblastic bone formation
The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor beta signaling.
Review
Lindner et al., West Scarborough, United States. In Trends Cardiovasc Med, 2007
Collagen triple helix repeat containing protein 1 (Cthrc1) is a gene product with novel biochemical activities, and its ability to reduce collagen deposition by inhibition of Smad2/3 activation could have major clinical applications in the fields of vascular disease, repair, and fibrosis.
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