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CTF18 Ctf18p

Ctf18, CHL12
CHTF18, CHTF8 (MIM 613202), and DCC1 (DSCC1; MIM 613203) are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009] (from NCBI)
Top mentioned proteins: DCC1, Rad17, PCNA, cardiotrophin-1, RFC5
Papers on Ctf18
Phosphoinositide 3-kinase beta controls replication factor C assembly and function.
Carrera et al., Madrid, Spain. In Nucleic Acids Res, 2013
Other processes that require mobile contact of proteins with DNA use alternative RFC complexes that exchange RFC1 for CTF18 or RAD17.
Disruption of CHTF18 causes defective meiotic recombination in male mice.
Kaestner et al., Philadelphia, United States. In Plos Genet, 2011
CHTF18 (chromosome transmission fidelity factor 18) is an evolutionarily conserved subunit of the Replication Factor C-like complex, CTF18-RLC.
New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.
GeneRIF
Freudenreich et al., Medford, United States. In Plos Genet, 2010
Together these results indicate that Ctf18-RFC has additional important functions in preserving genome stability, besides its role in sister chromatid cohesion, which we propose include lesion bypass by replication forks and post-replication repair.
Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8.
GeneRIF
Tsurimoto et al., Fukuoka, Japan. In J Biol Chem, 2010
Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8.
Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae.
Liang et al., Guangzhou, China. In Cell Cycle, 2010
We also show that overexpression of replication initiation proteins causes synthetic dosage lethality or growth defects in ctf1 and ctf18 mutants and that Ctf1p and Ctf18p physically interact with ORC, Cdt1p and MCM proteins.
Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells.
Lehmann et al., Nagasaki, Japan. In Mol Cell, 2010
The remaining repair synthesis is dependent on pol epsilon, recruitment of which is dependent on the alternative clamp loader CTF18-RFC.
The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair.
De Veylder et al., Gent, Belgium. In Plos Genet, 2010
The lack-of-cohesion phenotype was intensified in plants without functional CTF18, a replication fork factor needed for cohesion establishment.
Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target.
Hieter et al., Vancouver, Canada. In Mol Biol Cell, 2009
We identified SL interactions between members of the cohesin complex and CTF4, RAD27, and components of the alternative RFC(CTF18) complex.
Cohesin acetylation speeds the replication fork.
Impact
Jallepalli et al., New York City, United States. In Nature, 2009
Through single-molecule analysis, we demonstrate that the replication factor C (RFC)-CTF18 clamp loader (RFC(CTF18)) controls the velocity, spacing and restart activity of replication forks in human cells and is required for robust acetylation of cohesin's SMC3 subunit and sister chromatid cohesion.
The ELG1 clamp loader plays a role in sister chromatid cohesion.
GeneRIF
Kupiec et al., Tel Aviv-Yafo, Israel. In Plos One, 2008
Results suggest that Elg1, Ctf4, and Ctf18 may coordinate the relative movement of the replication fork with respect to the cohesin ring.
The Elg1-RFC clamp-loading complex performs a role in sister chromatid cohesion.
Skibbens et al., Bethlehem, United States. In Plos One, 2008
It is widely accepted that of the four Replication Factor C (RFC) complexes (defined by the associations of either Rfc1p, Ctf18p, Elg1p or Rad24p with Rfc2p-Rfc5p), only Ctf18-RFC functions in sister chromatid cohesion.
Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.
Boeke et al., Baltimore, United States. In Genetics, 2008
We also show that hst3 hst4 phenotypes can be suppressed by overexpression of the PCNA clamp loader large subunit, Rfc1p, and by inactivation of the alternative clamp loaders CTF18, RAD24, and ELG1.
Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1.
GeneRIF
Hurwitz et al., New York City, United States. In J Biol Chem, 2008
hChlR1 has a role in the establishment of sister chromatid cohesion, with Ctf18-RFC and Fen1
Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast.
Jongens et al., Philadelphia, United States. In Mol Hum Reprod, 2008
Cutlet/CTF18 encodes an evolutionarily conserved protein that is crucial for germline development in Drosophila melanogaster.
Single-gene deletions that restore mating competence to diploid yeast.
Kennedy et al., Seattle, United States. In Fems Yeast Res, 2008
Three of these, lacking CTF8, CTF18, and DCC1, mate at a low frequency with either MATa or MATalpha haploids.
RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.
GeneRIF
Noguchi et al., Philadelphia, United States. In Mol Biol Cell, 2008
RFC(Ctf18) and the Swi1-Swi3 complex function in separate and redundant pathways essential for replication fork stabilization to facilitate sister chromatid cohesion in fission yeast.
Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres.
Heierhorst et al., Australia. In Mol Cell Biol, 2007
Moreover, mdt1Delta leads to severe synthetic growth defects with a deletion of the recombination facilitator and telomere-positioning factor gene CTF18 already in the absence of exogenous DNA damage.
Ctf18 is required for homologous recombination-mediated double-strand break repair.
Seki et al., Sendai, Japan. In Nucleic Acids Res, 2006
In this study, we investigated whether Ctf18, a factor implicated in the establishment of sister chromatid cohesion, is involved in DSB repair in budding yeast.
A DNA integrity network in the yeast Saccharomyces cerevisiae.
Impact
Boeke et al., Baltimore, United States. In Cell, 2006
This genome-wide genetic interaction network also identified novel components (DIA2, NPT1, HST3, HST4, and the CSM1 module) that potentially contribute to mitotic DNA replication and genomic stability and revealed novel functions of well-studied genes (the CTF18 module) in DRC signaling.
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