Proteomic analysis of susceptibility in intestinal stromal tumors.
Beijing, China. In Genet Mol Res, 2014
Human SGC7901 gastric cells were selected and divided into a blank control group (untransfected SGC7901 cells), a negative control group [SGC7901 cells transfected with negative interference control-small interfering RNA (siRNA)], and a COOH-terminus tensin-like molecule (CTEN)-siRNA-1 group (SGC7901 cells transfected with CTEN-siRNA-1).
Long-term efficacy and safety of aerosolized tobramycin 300 mg/4 ml in cystic fibrosis.
Busko-Zdrój, Poland. In Pediatr Pulmonol, 2014
OBJECTIVES: The long-term safety and efficacy of intermittent (28-day "on"/"off" cycles) inhaled tobramycin nebulization solution 300 mg/4 ml (TNS4, Bramitob(®)/Bethkis(®)) was assessed over 56 weeks in CF patients aged ≥6 years having baseline 1 sec forced expiratory volume (FEV(1)) 40-80% predicted.
A mechanically-induced colon cancer cell population shows increased metastatic potential.
Urbana, United States. In Mol Cancer, 2013
The expression of some genes, such as ALDH3A1, TNS4, CLDN2, and AKR1B10, which are known to play important roles in cancer cell migration, invasion, proliferation and apoptosis, were increased in HCT-8 R cells.
Indirubin derivative 6BIO suppresses metastasis.
München, Germany. In Cancer Res, 2013
Instead, the Jak/STAT3 signaling pathway appeared to play a major role through modulation of its downstream migration regulators C-terminal tensin-like protein and matrix metalloproteinase 2. However, PDK1 and GSK3β contributed to the overall response to 6BIO, as silencing of all three pathways resulted in almost complete inhibition of migration, phenocopying the 6BIO response.