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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TSPY-like 2

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, Histone, CD4, POLYMERASE
Papers using CTCL antibodies
CD44 attenuates activation of the hippo signaling pathway and is a prime therapeutic target for glioblastoma.
Rosen Steven T et al., In The Journal of investigative dermatology, 2009
... Blood samples were collected from CTCL patients and peripheral blood mononuclear cells (PBMCs) were isolated using BD Vacutainer CPT tubes (BD Biosciences, San Jose, CA) ...
Array-based DNA methylation profiling in follicular lymphoma
Szlosarek P W et al., In Cell Death & Disease, 2008
... mantle cell lymphoma, MCL; marginal zone lymphoma, MZL; Burkitt's lymphoma, BL, Hodgkin's lymphoma, HL; and CTCL lymphoid paraffin sections were stained using an ASS1 antibody (BD Biosciences, Oxford, UK; dilution 1 : 100) ...
Papers on CTCL
Disruption of CCL20-CCR6 interaction inhibits metastasis of advanced cutaneous T-cell lymphoma.
Tagawa et al., Akita, Japan. In Oncotarget, Feb 2016
UNASSIGNED: We recently demonstrated that upregulation of a chemokine receptor CCR6 and its ligand CCL20 led to metastasis of advanced cutaneous T-cell lymphoma (CTCL) cells, suggesting the involvement of CCL20-CCR6 interaction in initiating CTCL cell metastasis.
Staphylococcus aureus enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma.
Odum et al., Copenhagen, Denmark. In Blood, Feb 2016
UNASSIGNED: Cutaneous T cell lymphoma (CTCL) is characterized by proliferation of malignant T cells in a chronic inflammatory environment.
Malignancy-associated pruritus.
Yosipovitch et al., Philadelphia, United States. In Eur J Pain, Jan 2016
Cutaneous T-cell lymphomas (CTCL), particularly more advanced stages, cause intractable pruritus and recent investigations into the pathophysiology of CTCL-associated itch have implicated cyotokine interleukin-31 as a putative mediator.
Romidepsin and azacitidine synergize in their epigenetic modulatory effects to induce apoptosis in CTCL.
Dummer et al., Zürich, Switzerland. In Clin Cancer Res, Jan 2016
UNASSIGNED: Purpose Cutaneous T cell lymphomas (CTCL) are a heterogeneous group of malignancies that despite available therapies commonly relapse.
The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.
Palomero et al., New York City, United States. In Nat Genet, Dec 2015
Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL) resulting from the malignant transformation of skin-homing central memory CD4(+) T cells.
The Therapeutic Potential of AN-7, a Novel Histone Deacetylase Inhibitor, for Treatment of Mycosis Fungoides/Sezary Syndrome Alone or with Doxorubicin.
Hodak et al., Tel Aviv-Yafo, Israel. In Plos One, Dec 2015
The 2 histone deacetylase inhibitors (HDACIs) approved for the treatment of cutaneous T-cell lymphoma (CTCL) including mycosis fungoides/sezary syndrome (MF/SS), suberoylanilide hydroxamic acid (SAHA) and romidepsin, are associated with low rates of overall response and high rates of adverse effects.
Marked lowering of high-density lipoprotein cholesterol levels due to high dose bexarotene therapy.
Garg et al., Dallas, United States. In J Clin Lipidol, Nov 2015
CONTEXT: Bexarotene is a retinoid X receptor agonist, which is currently used for the treatment of cutaneous T-cell lymphoma (CTCL).
Other Chemotherapeutic Agents in Cutaneous T-Cell Lymphoma.
Poligone et al., Penn Hills, United States. In Dermatol Clin, Oct 2015
Traditional chemotherapies, interleukins, phosphorylase inhibitors, and proteasome inhibitors are important therapies available to patients with cutaneous T-cell lymphoma (CTCL).
Genomic landscape of cutaneous T cell lymphoma.
Lifton et al., New Haven, United States. In Nat Genet, Sep 2015
Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes.
Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2.
Khavari et al., Stanford, United States. In Nat Genet, Sep 2015
Effective treatment options for CTCL are limited, and the genetic basis of these T cell lymphomas remains incompletely characterized.
Belinostat in patients with refractory or relapsed peripheral T-cell lymphoma: a perspective review.
O'Connor et al., New York City, United States. In Ther Adv Hematol, Aug 2015
Key clinical trials covered include phase I/II evaluation of belinostat in hematologic malignancies, cutaneous T-cell lymphoma (CTCL) and PTCL.
Primary cutaneous T-cell lymphoma presenting as mycosis fungoides with a T-/null-cell phenotype: report of two cases.
Ortonne et al., Amiens, France. In Br J Dermatol, Jun 2015
Variations in the clinical and histological presentation of cutaneous T-cell lymphoma (CTCL) can hamper diagnosis.
Recent advances in primary cutaneous T-cell lymphoma.
Guenova et al., Zürich, Switzerland. In Curr Opin Oncol, Mar 2015
PURPOSE OF REVIEW: Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of skin-homing T-cell neoplasms, which represent approximately 75% of all primary cutaneous lymphomas.
Multicenter phase II study of mogamulizumab (KW-0761), a defucosylated anti-cc chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma.
Ueda et al., Izumo, Japan. In J Clin Oncol, 2014
This multicenter phase II study evaluated the efficacy and safety of mogamulizumab in patients with relapsed PTCL and cutaneous T-cell lymphoma (CTCL).
hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies.
Zographos et al., Athens, Greece. In Proteins, 2012
hCINAP may not simply regulate nucleotide homeostasis, but may have broader functionality, including control of Cajal body assembly and disassembly
Role of the Y-located putative gonadoblastoma gene in human spermatogenesis.
Kido et al., San Francisco, United States. In Syst Biol Reprod Med, 2011
TSPX is principally expressed in Sertoli cells in the human testis.
Depletion of hCINAP by RNA interference causes defects in Cajal body formation, histone transcription, and cell viability.
Zheng et al., Beijing, China. In Cell Mol Life Sci, 2010
knockdown of CINAP expression results in marked reduction of histone transcription, lower levels of U small nuclear RNAs (U1, U2, U4, and U5), and a loss of cell viability
Phase III placebo-controlled trial of denileukin diftitox for patients with cutaneous T-cell lymphoma.
Negro-Vilar et al., Washington, D.C., United States. In J Clin Oncol, 2010
PURPOSE This phase III, placebo-controlled, randomized trial was designed to investigate efficacy and safety of two doses of denileukin diftitox (DD; DAB(389)-interleukin-2 [IL-2]), a recombinant fusion protein targeting IL-2 receptor-expressing malignant T lymphocytes, in patients with stage IA to III, CD25 assay-positive cutaneous T-cell lymphoma (CTCL), including the mycosis fungoides and Sézary syndrome forms of the disease, who had received up to three prior therapies.
Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis.
Jakowlew et al., Gaithersburg, United States. In Carcinogenesis, 2008
a role for DENTT as a suppressor of the tumorigenic phenotype.
Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways.
Chai et al., Melbourne, Australia. In J Biol Chem, 2007
CDA1 induces p53- and MEK/ERK1/2 MAPK-dependent expression of p21 by acting through the p53 responsive element in the p21 promoter and this contributes to its antiproliferative activity
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