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C-terminal binding protein 2

CtBP2, C-terminal binding protein 2
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, Histone, HAIR
Papers using CtBP2 antibodies
Molecular dissection of the photoreceptor ribbon synapse
Supplier
Brandstätter Johann H. et al., In The Journal of Cell Biology, 1996
... mouse anti-CtBP1 (postembedding immunoelectron microscopy [post-EM] 1:500; immunohistochemistry [IHC] 1:2,500–1:5,000; Western blot [WB] 1:5,000) and anti-CtBP2 mAbs (post-EM 1:1,000; IHC 1:10,000; WB 1:5,000; BD Biosciences), rabbit anti-pan-Munc13 pAb (WB ...
Papers on CtBP2
Pituitary Adenylate Cyclase Activating Polypeptide, A Potential Therapeutic Agent for Diabetic Retinopathy in Rats: Focus on the Vertical Information Processing Pathway.
New
Gabriel et al., Pécs, Hungary. In Neurotox Res, Feb 2016
The ribbon synapse was marked with C-terminal binding protein 2/Bassoon and formed horseshoe-shape ribbons, which were more retained in PACAP-treated diabetic retinas than in DR rats.
Down-regulation of the zinc-finger homeobox protein TSHZ2 releases GLI1 from the nuclear repressor complex to restore its transcriptional activity during mammary tumorigenesis.
New
Kasai et al., Japan. In Oncotarget, Jan 2016
We found that GLI1 forms a ternary complex with CtBP2 in the presence of TSHZ2 and that the transcriptional activity of GLI1 is suppressed by TSHZ2 in a CtBP-dependent manner.
CtBP2 Regulates TGFβ2-Induced Epithelial-Mesenchymal Transition Through Notch Signaling Pathway in Lens Epithelial Cells.
New
Guan et al., Nantong, China. In Curr Eye Res, Jan 2016
C-terminal binding protein 2 (CtBP2) has been reported to be essential in EMT and embryonic development.
CtBP2 overexpression is associated with tumorigenesis and poor clinical outcome of prostate cancer.
New
Xu et al., Tianjin, China. In Arch Med Sci, Jan 2016
INTRODUCTION: The aim of the study was to evaluate the expression of CtBP2 in prostate cancer and to determine its relationship with clinicopathologic parameters.
FGF22 protects hearing function from gentamycin ototoxicity by maintaining ribbon synapse number.
New
Ma et al., Zhenjiang, China. In Hear Res, Jan 2016
Immunostaining with anti- GluR2&3/CtBP2 was used to estimate the number of ribbon synapses in the cochlea.
Morphological correlates of hearing loss after cochlear implantation and electro-acoustic stimulation in a hearing-impaired Guinea pig model.
New
Li et al., Portland, United States. In Hear Res, Sep 2015
The organ of Corti was immunolabeled with phalloidin, anti-CtBP2, and anti-GluR2 to quantify hair cells, ribbons and post-synaptic receptors.
Ctbp2 Modulates NuRD-Mediated Deacetylation of H3K27 and Facilitates PRC2-Mediated H3K27me3 in Active Embryonic Stem Cell Genes During Exit from Pluripotency.
New
Youn et al., Seoul, South Korea. In Stem Cells, Aug 2015
In this study, we demonstrate that C-terminal binding protein 2 (Ctbp2) regulates nucleosome remodeling and deacetylation (NuRD)-mediated deacetylation of H3K27 and facilitates recruitment of polycomb repressive complex 2 (PRC2)-mediated H3K27me3 in active ESC genes for exit from pluripotency during differentiation.
Mechanism study of peptide GMBP1 and its receptor GRP78 in modulating gastric cancer MDR by iTRAQ-based proteomic analysis.
Ding et al., Xi'an, China. In Bmc Cancer, 2014
Two differentially expressed proteins, CTBP2 and EIF4E, were selected and validated by western blotting.
C-terminal binding proteins: central players in development and disease.
Review
Linseman et al., In Biomol Concepts, 2014
Although the invertebrate genome encodes one CtBP protein, two CtBPs (CtBP1 and CtBP2) are encoded by the vertebrate genome and perform both unique and duplicative functions.
Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.
Impact
Zou et al., Ann Arbor, United States. In Immunity, 2013
miRNA101 subsequently repressesed the corepressor gene C-terminal binding protein-2 (CtBP2), and CtBP2 directly targeted stem cell core genes resulting in increased cancer cell stemness and increasing metastatic and tumorigenic potential.
APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC.
GeneRIF
Behrens et al., Erlangen, Germany. In Hum Mol Genet, 2011
CtBP1 and CtBP2 promote the oligomerization of truncated APC through binding to the 15 amino acid repeats of truncated APC.
Ataxin-1 occupies the promoter region of E-cadherin in vivo and activates CtBP2-repressed promoter.
GeneRIF
Kang et al., Seoul, South Korea. In Biochim Biophys Acta, 2011
This study demonstrates that ataxin-1 occupies the promoter region of E-cadherin in vivo and that ataxin-1 activates the promoter in a CtBP2-mediated transcriptional regulation manner.
CtBPs promote mitotic fidelity through their activities in the cell nucleus.
GeneRIF
Blaydes et al., Southampton, United Kingdom. In Oncogene, 2011
we demonstrate that it is the interaction of CtBPs with transcriptional regulators and/or chromatin-modifying enzymes in the cell nucleus, rather than their role in Golgi fission, which is critical for the maintenance of mitotic fidelity.
Expression of CtBP family protein isoforms in breast cancer and their role in chemoresistance.
GeneRIF
Blaydes et al., Southampton, United Kingdom. In Biol Cell, 2010
CtBP2 proteins are ubiquitously expressed in all lines and tumour samples.
Selective down-regulation of Th2 cytokines by C-terminal binding protein 2 in human T cells.
GeneRIF
Kaminuma et al., Tokyo, Japan. In Int Arch Allergy Immunol, 2009
CtBP2 selectively down-regulates Th2 cytokines, therefore it is a potential target for the treatment of allergic diseases.
The transcriptional corepressor CtBP: a foe of multiple tumor suppressors.
Review
Chinnadurai, Saint Louis, United States. In Cancer Res, 2009
CtBP1 and CtBP2 are closely related and evolutionarily conserved transcriptional corepressors.
Multiple loci identified in a genome-wide association study of prostate cancer.
Impact
Chanock et al., Bethesda, United States. In Nat Genet, 2008
Loci on chromosome 10 include MSMB, which encodes beta-microseminoprotein, a primary constituent of semen and a proposed prostate cancer biomarker, and CTBP2, a gene with antiapoptotic activity; the locus on chromosome 7 is at JAZF1, a transcriptional repressor that is fused by chromosome translocation to SUZ12 in endometrial cancer.
Transcriptional regulation by C-terminal binding proteins.
Review
Chinnadurai, Saint Louis, United States. In Int J Biochem Cell Biol, 2006
The vertebrate C-terminal binding proteins (CtBP1 and CtBP2) are highly related and are functionally redundant for certain developmental processes and non-redundant for others.
CtBP family proteins: more than transcriptional corepressors.
Review
Chinnadurai, Saint Louis, United States. In Bioessays, 2003
Studies with mutant mouse suggest that the two mouse genes, Ctbp1 and Ctbp2, play unique and redundant gene regulatory roles during development.1
Dual use of the transcriptional repressor (CtBP2)/ribbon synapse (RIBEYE) gene: how prevalent are multifunctional genes?
Review
Piatigorsky, Bethesda, United States. In Trends Neurosci, 2001
Recently, an approximately 120 kDa protein called RIBEYE has been identified in purified ribbons of bovine retina.
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