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Phosphate cytidylyltransferase 1, choline, beta

CTB
Chitobiase is a lysosomal glycosidase involved in degradation of asparagine-linked oligosaccharides on glycoproteins (Aronson and Kuranda, 1989 [PubMed 2531691]).[supplied by OMIM, Nov 2010] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, IgA
Papers on CTB
Enhanced truncated-t-PA (CT-b) expression in high-cell-density fed-batch cultures of Pichia pastoris through optimization of a mixed feeding strategy by response surface methodology.
New
Maghsoudi et al., Tehrān, Iran. In Bioprocess Biosyst Eng, Feb 2016
UNASSIGNED: Recently, Pichia pastoris has been the focal point of interest as an expression system for production of many recombinant proteins.
Factors influencing the transfection efficiency and cellular uptake mechanisms of Pluronic P123-modified polypropyleneimine/pDNA polyplexes in multidrug resistant breast cancer cells.
New
Sha et al., Shanghai, China. In Colloids Surf B Biointerfaces, Jan 2016
Colocalization experiments with TRITC-transferrin (CME indicator), Alexa Fluor 555-CTB (CvME indicator), monoclonal anti-α-tubulin (microtubule indicator), and LysoTracker Green (Endosome/lysosome indicator) were carried out to confirm the internalization routes.
Release from Th1-type immune tolerance in spleen and enhanced production of IL-5 in Peyer's patch by cholera toxin B induce the glomerular deposition of IgA.
New
Tomino et al., Tokyo, Japan. In Immunobiology, Jan 2016
GATA-3 Tg mice were immunized orally using OVA plus cholera toxin B (CTB), and measurement of the serum IgA antibody level and histopathological examination were performed.
Assessment of retinal ganglion cell damage in glaucomatous optic neuropathy: Axon transport, injury and soma loss.
Review
New
Chauhan et al., Halifax, Canada. In Exp Eye Res, Dec 2015
Horseradish peroxidase (HRP), rhodamine-B-isothiocyanate (RITC) and cholera toxin-B (CTB) fluorescent conjugates have proven to be effective reporters of AT.
Oral Administration of Silkworm-Produced GAD65 and Insulin Bi-Autoantigens against Type 1 Diabetes.
New
Jin et al., Hangzhou, China. In Plos One, Dec 2015
In this study, we generated a fusion protein CTB-Ins-GAD composed of CTB (cholera toxin B subunit), insulin, and three copies of GAD65 peptide 531-545, which were efficiently produced in silkworm pupae, to evaluate its protective effect against T1D.
Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation.
Review
New
Blois et al., Berlin, Germany. In Am J Reprod Immunol, Dec 2015
In canine early pregnancy, we observed that gal-1 and gal-9 were expressed strongly in cytotrophoblast (CTB) cells compared to gal-3, and no galectin expression was observed in syncytiotrophoblast (STB) cells.
Cholera toxin B: one subunit with many pharmaceutical applications.
Review
New
Matoba et al., Louisville, United States. In Toxins (basel), Mar 2015
The major virulence factor is cholera toxin (CT), which consists of two subunits: the A subunit (CTA) and the B subunit (CTB).
N-Glycosylation of Cholera Toxin B Subunit: Serendipity for Novel Plant-Made Vaccines?
Matoba, Owensboro, United States. In Front Plant Sci, 2014
The non-toxic B subunit of cholera toxin (CTB) has attracted considerable interests from vaccinologists due to strong mucosal immunomodulatory effects and potential utility as a vaccine scaffold for heterologous antigens.
Cholera Toxin Subunit B as Adjuvant--An Accelerator in Protective Immunity and a Break in Autoimmunity.
Review
Stratmann, Barcelona, Spain. In Vaccines (basel), 2014
Cholera toxin subunit B (CTB) is the nontoxic portion of cholera toxin.
The Role of the Paratrigeminal Nucleus in Vagal Afferent Evoked Respiratory Reflexes: A Neuroanatomical and Functional Study in Guinea Pigs.
McGovern et al., Australia. In Front Physiol, 2014
Thus, microinjection of fluorescently conjugated cholera toxin B (CT-B) neural tracers into the caudal nTS and Pa5 resulted in highly specific retrograde labeling of neurons in the nodose and jugular ganglia, respectively.
The globins of Campylobacter jejuni.
Review
Shepherd et al., Sheffield, United Kingdom. In Adv Microb Physiol, 2012
To combat the toxic effects of this nitrosative stress, C. jejuni upregulates a small regulon under the control of the transcriptional activator NssR, which positively regulates the expression of a single-domain globin protein (Cgb) and a truncated globin protein (Ctb).
Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2.
GeneRIF
Beccari et al., Perugia, Italy. In Biochim Biophys Acta, 2012
In di-N-acetylchitobiase-deficient mice Man2GlcNAc2 urine levels were up to 10-fold higher than in urine of wild-type animals.
Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold.
GeneRIF
Cornell et al., Canada. In J Biol Chem, 2009
The 2.2-A structure reveals a CCT236 homodimer in complex with the reaction product, CDP-choline.
Mass spectrometric identification of human phosphate cytidylyltransferase 1 as a novel calcium oxalate crystal growth inhibitor purified from human renal stone matrix.
GeneRIF
Tandon et al., India. In Clin Chim Acta, 2009
Human phosphate cytidylyltransferase 1, choline, beta is a novel CaOx crystal growth inhibitor.
Phosphatidylcholine biosynthesis via CTP:phosphocholine cytidylyltransferase 2 facilitates neurite outgrowth and branching.
GeneRIF
Vance et al., Edmonton, Canada. In J Biol Chem, 2008
Results highlight the importance of CTbeta2 in neurons for promoting neurite outgrowth and branching and represent the first identification of a lipid biosynthetic enzyme that facilitates these functions.
Optimum substrate size and specific anomer requirements for the reducing-end glycoside hydrolase di-N-acetylchitobiase.
GeneRIF
Halloran et al., Mobile, United States. In Biosci Biotechnol Biochem, 2006
biochemical behavior of di-N-acetylchitobiase indicates it has three subsites, -2, -1, +1, in which the reducing-end trimer of any sized chitooligosaccharide is bound. The +1 site is specific for an alpha-anomer.
Lipid raft proteins have a random distribution during localized activation of the T-cell receptor.
Impact
Nichols et al., Cambridge, United Kingdom. In Nat Cell Biol, 2004
Stimulation of TCR signalling in Jurkat cells resulted in localized increases in fluorescence of GPI-linked fluorescent proteins and cholera toxin B-subunit (CTB).
A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes.
Impact
Langridge et al., Loma Linda, United States. In Nat Biotechnol, 1998
To direct delivery of plant-synthesized insulin to the gut-associated lymphoid tissues, insulin was linked to the C-terminus of the cholera toxin B subunit (CTB).
Efficacy of a food plant-based oral cholera toxin B subunit vaccine.
Impact
Langridge et al., Loma Linda, United States. In Nat Biotechnol, 1998
Transgenic potatoes were engineered to synthesize a cholera toxin B subunit (CTB) pentamer with affinity for GMI-ganglioside.
Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin.
Impact
Falkow et al., In Nature, 1981
Binding studies and competition experiments indicate that the membrane receptors for cholera toxin B subunit (CT-B) and LT-B are similar but not identical (these studies were performed before by LT was purified to homogeneity).
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