The adaptor protein Crk in immune response.
Houston, United States. In Immunol Cell Biol, 2014
The adaptor proteins Crk (CT10 (chicken tumor virus number 10) regulator of kinase), including CrkI, CrkII and Crk-like, are important signal molecules that regulate a variety of cellular processes.
GAB2--a scaffolding protein in cancer.
New York City, United States. In Mol Cancer Res, 2012
Grb2-associated binding protein 2 (GAB2) scaffolding protein is an intermediary molecule that links plasma membrane receptor signaling including receptor tyrosine kinases with the downstream effectors, such as protein tyrosine phosphatase, nonreceptor type 11 (SHP2), p85 subunit of phosphoinositide-3 kinase (PI3-K), phospholipase C-gamma 1 (PLC-γ), v-crk sarcoma virus CT10 (CRK), Src homology 2 domain containing transforming protein 1 (SHC), and SH2 containing inositol phosphatase (SHIP).
Prognostic factors in chronic myeloid leukaemia.
Valencia, Spain. In Best Pract Res Clin Haematol, 2009
Biological markers such as gene expression profile, v-crk sarcoma virus CT10 oncogene homologue (avian)-like (Crkl) phosphorylation or expression of imatinib transporter proteins have been shown to be useful to predict the response to imatinib.