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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cystatin E/M

CST6, cystatin M, cystatin E/M, cystatin M/E, cystatin M/E is
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cystatins, CAN, HAIR, Transglutaminase, HAD
Papers on CST6
The effect of chronic kidney disease on the urine proteome in the domestic cat (Felis catus).
New
Isani et al., Bologna, Italy. In Vet J, Apr 2015
In particular, increased expression of retinol-binding protein, cystatin M and apolipoprotein-H associated with decreased expression of uromodulin and cauxin confirmed tubular damage in CKD cats suggesting that these proteins are candidate biomarkers.
The hand eczema proteome: imbalance of epidermal barrier proteins.
New
Hauck et al., München, Germany. In Br J Dermatol, Apr 2015
Among them we found several barrier proteins: filaggrin (FLG), FLG-2 and hornerin were all downregulated in the hand eczema samples, as were the desquamation-related enzymes kallikrein-related peptidase (KLK)5 and KLK7 and cystatin E/M.
Methylation profiling of 48 candidate genes in tumor and matched normal tissues from breast cancer patients.
New
Wang et al., Changsha, China. In Breast Cancer Res Treat, Feb 2015
These 13 genes included CST6, DBC1, EGFR, GREM1, GSTP1, IGFBP3, PDGFRB, PPM1E, SFRP1, SFRP2, SOX17, TNFRSF10D, and WRN.
Analysis of Stage-Specific Gene Expression Profiles in the Uterine Endometrium during Pregnancy in Pigs.
Ka et al., Wŏnju, South Korea. In Plos One, 2014
Furthermore, several pregnancy-related hub genes such as ALPPL2, RANBP17, NF1B, SPP1, and CST6 were discovered through network analysis.
Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity.
Rongved et al., Oslo, Norway. In Bioorg Med Chem, 2014
Furthermore, co-administration of the prodrug either with the potent legumain inhibitor cystatin E/M or the endocytosis inhibitor Dyngo-4a inhibited cell death, indicating that the prodrug toxicity was dependent on both asparaginyl endopeptidase activity and endocytosis.
Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers.
Belinsky et al., Baltimore, United States. In Carcinogenesis, 2014
The prevalence for methylation of the remaining 38 genes in lung adenocarcinomas from S (n = 97) and NS (n = 75) ranged from 8-89% and significantly differs between S and NS for CPEB1, CST6, EMILIN2, LAYN and MARVELD3 (P < 0.05).
Proteomic analysis of uterine fluid during the pre-implantation period of pregnancy in cattle.
Lonergan et al., Dublin, Ireland. In Reproduction, 2014
Of the most abundant proteins present, iTRAQ analysis revealed that RPB4, TIMP2 and GC had the same expression pattern as IFNT, while the abundance of IDH1, CST6 and GDI2 decreased on either day 16 or 19.
TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.
Mullan et al., Belfast, United Kingdom. In Oncotarget, 2014
We have identified the cysteine protease inhibitor Cystatin 6 (CST6) as a consistently repressed TBX2 target gene, co-repressed through a mechanism involving Early Growth Response 1 (EGR1).
Development of highly sensitive and specific mRNA multiplex system (XCYR1) for forensic human body fluids and tissues identification.
Zhao et al., Shanghai, China. In Plos One, 2013
In this study, we selected 16 tissue specific biomarkers to evaluate their specificities and sensitivities for human body fluids and tissues identification, including porphobilinogen deaminase (PBGD), hemoglobin beta (HBB) and Glycophorin A (GLY) for circulatory blood, protamine 2 (PRM2) and transglutaminase 4 (TGM4) for semen, mucin 4 (MUC4) and human beta defensin 1(HBD1) for vaginal secretion, matrix metalloproteinases 7 and 11 (MMP7 and MMP11) for menstrual blood, keratin 4(KRT4) for oral mucosa, loricrin (LOR) and cystatin 6 (CST6) for skin, histatin 3(HTN3) for saliva, statherin (STATH) for nasal secretion, dermcidin (DCD) for sweat and uromodulin (UMOD) for urine.
DNA methylation biomarkers predict progression-free and overall survival of metastatic renal cell cancer (mRCC) treated with antiangiogenic therapies.
Serth et al., Hannover, Germany. In Plos One, 2013
Primary tumor tissues from 18 patients receiving targeted therapy were examined retrospectively using quantitative methylation-specific PCR analysis of CST6, LAD1, hsa-miR-124-3, and hsa-miR-9-1 CpG islands.
Cysteine proteases: mode of action and role in epidermal differentiation.
Review
Philpott et al., London, United Kingdom. In Cell Tissue Res, 2013
In addition, evidence continues to accumulate that papain-like cysteine proteases and an inhibitor cystatin M/E largely confined to the cutaneous epithelia also play key roles in the process.
Methylation of cystatin M promoter is associated with unfavorable prognosis in operable breast cancer.
GeneRIF
Lianidou et al., Athens, Greece. In Int J Cancer, 2010
Methylation of cystatin M promoter is associated with breast cancer.
Cystatin E/M suppresses legumain activity and invasion of human melanoma.
GeneRIF
Solberg et al., Oslo, Norway. In Bmc Cancer, 2009
the level of cystatin E/M regulates legumain activity and hence the invasive potential of human melanoma cells
Cystatin M loss is associated with the losses of estrogen receptor, progesterone receptor, and HER4 in invasive breast cancer.
GeneRIF
Kim et al., Suwŏn, South Korea. In Breast Cancer Res, 2009
An association between the quantity of CST6 methylation and the expression statuses of estrogen receptor, progesterone receptor, and HER4 in tumor tissues was found
Frequent loss of cystatin E/M expression implicated in the progression of prostate cancer.
GeneRIF
Rao et al., Peoria, United States. In Oncogene, 2009
Results suggest that the downregulation of the CST6 gene is associated with promoter histone modifications and that this association plays an important role in prostate cancer progression during the invasive and metastatic stages of the disease.
The biology of cystatin M/E and its cognate target proteases.
Review
GeneRIF
Schalkwijk et al., Nijmegen, Netherlands. In J Invest Dermatol, 2009
cystatin M/E has a role in skin barrier formation and a potential role as a tumor suppressor gene [review]
Epigenetic regulation of cystatins in cancer.
Review
Coleman et al., Chapel Hill, United States. In Front Biosci, 2008
Four cystatins have been extensively studied: cystatin A, cystatin B, cystatin C, and cystatin M. Aberrant regulation of cystatins occurs in a number of diseases, including cancer and certain neurodegenerative disorders.
Epidermal differentiation: the role of proteases and their inhibitors.
Review
Zeeuwen, Nijmegen, Netherlands. In Eur J Cell Biol, 2004
Notably, our recent findings on the role of cystatin M/E and legumain as a functional dyad in skin and hair follicle cornification, a paradigm example of the regulatory functions exerted by epidermal proteases, will be discussed.
Unstable minisatellite expansion causing recessively inherited myoclonus epilepsy, EPM1.
Impact
Lehesjoki et al., Helsinki, Finland. In Nat Genet, 1997
6) and the refinement of the critical region to a small interval, positional cloning identified the gene encoding cystatin B (CST6), a cysteine protease inhibitor, as the gene underlying EPM1 (ref.
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