RCAN 1 and 3 proteins regulate thymic positive selection.
Barcelona, Spain. In Biochem Biophys Res Commun, Jun 2015
Overexpression of human RCAN3 and RCAN1 can modulate T cell development by increasing positive selection-related surface markers, as well as the "Erk(hi) competence state" in double positive thymocytes, a characteristic molecular signature of positive selection, without affecting CN activity.
The rapidly expanding CREC protein family: members, localization, function, and role in disease.
Århus, Denmark. In Bioessays, 2009
The CREC family of low affinity, Ca2+-binding, multiple EF-hand proteins are encoded by five genes, RCN1, RCN2, RCN3, SDF4, and CALU, resulting in reticulocalbin, ER Ca2+-binding protein of 55 kDa (ERC-55), reticulocalbin-3, Ca2+-binding protein of 45 kDa (Cab45), and calumenin.