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COP9 constitutive photomorphogenic homolog subunit 6

CSN6, hVIP, COPS6, Vpr-interacting protein, Sgn6
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on CSN6
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
GeneRIF
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
COPS6 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
GeneRIF
Lee et al., Houston, United States. In J Clin Invest, 2011
loss of CSN6 enhances p53-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2-p53 signaling pathway
The COP9 signalosome-mediated deneddylation is stimulated by caspases during apoptosis.
GeneRIF
Dubiel et al., Berlin, Germany. In Apoptosis, 2008
For the first time our data demonstrate that CSN-mediated deneddylation can be regulated by active Casp3 and that the CSN executes a specific function during the apoptotic process.
The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis.
GeneRIF
Ulevitch et al., Los Angeles, United States. In J Biol Chem, 2007
critical role of caspase 8 in the processing of CSN6.
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