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COP9 constitutive photomorphogenic homolog subunit 4

CSN4, COPS4, ATS4
This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Jab1, Cullin, Ubiquitin, NEDD8, CAN
Papers on CSN4
Crystal structure of the human COP9 signalosome.
Impact
Thomä et al., Basel, Switzerland. In Nature, 2014
We find that neddylated CRL binding to CSN is sensed by CSN4, and communicated to CSN5 with the assistance of CSN6, resulting in activation of the deneddylase.
Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes.
Dubiel et al., Martinsried, Germany. In Biochem Biophys Res Commun, 2014
Compared to 3D models of negatively stained CSN complexes, densities assigned to CSN2 and CSN4 are better defined in the cryo-map.
Regulation of Cop9 signalosome activity by the EF-hand Ca2+-binding protein tescalcin.
Slepak et al., Miami, United States. In J Cell Sci, 2014
Here, we identify CSN4 (subunit 4 of the COP9 signalosome) as a novel binding partner of tescalcin.
COP9 subunits 4 and 5 target soluble guanylyl cyclase α1 and p53 in prostate cancer cells.
Shemshedini et al., Toledo, United States. In Mol Endocrinol, 2014
We identified the COP9 signalosome subunit 4 (CSN4) as a novel interacting partner for sGCα1.
The organization of a CSN5-containing subcomplex of the COP9 signalosome.
Hirsch et al., Tel Aviv-Yafo, Israel. In J Biol Chem, 2013
As an essential step to understanding the structure and assembly of a CSN5-containing subcomplex of the CSN, we reconstituted a CSN4-5-6-7 subcomplex.
Ubiquitin/proteasome-mediated proteolysis is involved in the response to flooding stress in soybean roots, independent of oxygen limitation.
Komatsu et al., Tsukuba, Japan. In Plant Sci, 2012
Immunoblot analyses were performed using antibodies against two subunits of 26S proteasome, Rpt5 and Rpn10, 20S proteasome and two subunits of COP9 signalosome (CSN), CSN4 and CSN5, to compare between flooded and untreated roots.
CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.
GeneRIF
Warner et al., London, United Kingdom. In Embo J, 2011
Identified is a novel-binding partner of torsin A, the subunit 4 (CSN4) of CSN signalosome.
The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation.
Bianchi et al., Paris, France. In J Biol Chem, 2010
Down-regulation of human CSN4 or CSN5 induced proteasome-mediated degradation of the ubiquitin-conjugating enzyme UBC3/Cdc34.
DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression.
Zhou et al., Beijing, China. In Bmc Mol Biol, 2009
A high level of constitutive expression of gamma H2AX was observed in another ATM deficient cell line ATS4.
The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting.
Blau et al., New York City, United States. In J Neurosci, 2009
We found that null mutations in the genes encoding the CSN4 and CSN5 subunits prevent normal TIM degradation by light in the pacemaker lateral neurons (LNs) as does LN-specific expression of a dominant-negative CSN5 transgene.
Auxin responses in mutants of the Arabidopsis CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome.
Schwechheimer et al., Tübingen, Germany. In Plant Physiol, 2008
Whether the CSN5 monomer, which is maintained in csn mutants such as csn3 or csn4, has a functional role, remains to be established.
The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
GeneRIF
Schwechheimer et al., Tübingen, Germany. In Development, 2008
Data suggest that Arabidopsis csn mutants undergo DNA damage, which might be the cause of the delay in G2 cell cycle progression.
Correlation of physician seniority with increased emergency department efficiency during a resident doctors' strike.
Brydon et al., Hamilton, New Zealand. In N Z Med J, 2008
Waiting times were reduced for ATS3 (43.8 vs 73.6 minutes, p<0.001) and ATS4 (53.7 vs 82.0 minutes, p<0.001) during the strike period.
Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development.
Segal et al., Tel Aviv-Yafo, Israel. In Genes Cells, 2008
Null mutants generated in this study are larval lethal, showing phenotypes associated with mutations in either CSN4 (molting defects) or CSN5 (melanotic tumors).
Retinoblastoma protein regulation by the COP9 signalosome.
GeneRIF
Henry et al., East Lansing, United States. In Mol Biol Cell, 2007
the CSN4 subunit of the COP9 signalosome co-occupies retinoblastoma target gene promoters with Rbf2
Differentially expressed genes associated with dormancy or germination of Arabidopsis thaliana seeds.
Hilhorst et al., Wageningen, Netherlands. In Planta, 2005
Expression of the dormancy-associated genes ATS2 and ATS4, encoding a caleosin-like protein and a protein similar to a low-temperature-induced protein respectively, was high in the dry seed and decreased during germination.
The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis.
GeneRIF
Beckendorf et al., Berkeley, United States. In Dev Cell, 2003
we link the CSN to the degradation of Cyclin E, which promotes the G1-S transition in the cell cycle and then is rapidly degraded by the ubiquitin-proteasome pathway
COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.
GeneRIF
Chamovitz et al., Tel Aviv-Yafo, Israel. In Development, 2002
COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.
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