Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors.
United States. In Pharmacol Res, Apr 2015
The chief phosphorylation sites of human Src include an activating pTyr419 that results from phosphorylation in the kinase domain by an adjacent Src molecule and an inhibitory pTyr530 in the regulatory tail that results from phosphorylation by C-terminal Src kinase (Csk) or Chk (Csk homologous kinase).
PAG--a multipurpose transmembrane adaptor protein.
Praha, Czech Republic. In Oncogene, 2014
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), also known as Csk-binding protein (Cbp), is a ubiquitously expressed transmembrane adaptor protein present in lipid rafts and involved in a number of signaling pathways.
Redox circuitries driving Src regulation.
Florence, Italy. In Antioxid Redox Signal, 2014
RECENT ADVANCES: Several recent insights have reported that, alongside the well-known phosphorylation/dephosphorylation control, cysteine oxidation is a further mechanism of enzyme activation for both c-Src kinase and its oncogenic counterparts.
Stress transmission within the cell.
Boston, United States. In Compr Physiol, 2011
During past decades, it has become evident that the deformable cytoskeleton (CSK), an intracellular network of various filamentous biopolymers, provides a physical basis for transducing mechanical signals into biochemical responses.
Genome-wide association study of blood pressure and hypertension.
More papers using
Framingham, United States. In Nat Genet, 2009
When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1).
In The Journal of Experimental Medicine, 1993