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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

C-src tyrosine kinase

Csk, c-Src kinase, c-Src tyrosine kinase
Encodes a chloroplast sensor kinase (CSK) that shares common ancestors with cyanobacterial histidine sensor kinases. CSK is synthesised in the cytosol and imported into the chloroplast as a protein precusor. CSK is autophosphorylated and required for control of transcription of chloroplast genes by the redox state of an electron carrier connecting photosystems I and II. (from NCBI)
Top mentioned proteins: Src, V1a, CAN, TLR2, Actin
Papers using Csk antibodies
The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1
Supplier
Benistant Christine et al., In The Journal of Cell Biology, 2005
... Src antibody was obtained from Invitrogen, anti–pan-caveolin from BD Biosciences, anti-ERKs (SC-94) and -Csk from Santa Cruz Biotechnology, Inc., anti-pY ...
PTP-1B is an essential positive regulator of platelet integrin signaling
Supplier
Shattil Sanford J. et al., In The Journal of Cell Biology, 2003
... CD41 (integrin αIIb subunit), FITC-conjugated hamster anti–mouse CD61 (integrin β3 subunit), and mouse mAb to Csk were from BD Biosciences.
Murine cytomegalovirus paralyzes macrophages by blocking IFN gamma-induced promoter assembly.
Supplier
Means Terry, In PLoS ONE, 2002
... CSK4; Calbiochem) was stored at 1 mg/ml in endotoxin-tested water (Invitrogen Life Technologies).
Regulation of cytochrome c oxidase activity by c-Src in osteoclasts
Supplier
Baron Roland et al., In The Journal of Cell Biology, 1997
... Mouse monoclonal anti-cathepsin D, anti-calnexin, anti-EEA1, anti-MEK1, and anti-Csk antibodies were obtained from BD Biosciences.
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Papers on Csk
Csk / Src / EGFR Signaling regulates migration of myofibroblasts and alveolarization.
New
Zhang et al., Shanghai, China. In Am J Physiol Lung Cell Mol Physiol, Feb 2016
In addition, Csk activity was downregulated in myofibroblasts treated with LPS, while activation of Src or EGFR was upregulated by LPS treatment.
Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.
New
Qu et al., Toronto, Canada. In Proc Natl Acad Sci U S A, Feb 2016
Further mechanistic analyses reveal that GOF mutant Shp2 hyperactivates the Polo-like kinase 1 (Plk1) kinase by enhancing c-Src kinase-mediated tyrosine phosphorylation of Plk1.
Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 that Confer Risk for Type 1 Diabetes.
New
Concannon et al., Gainesville, United States. In Diabetes, Jan 2016
This isoform competes with the wild-type LYP for binding to CSK and results in hyporesponsiveness of CD4(+) T cells to antigen stimulation in T1D subjects.
Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure.
New
Oh et al., Seoul, South Korea. In Plos One, Dec 2015
METHODS AND RESULTS: CSK and ULK3 were selected as candidate genes based on eQTL analysis studies that showed the association between gene transcript levels and the lead SNP (rs1378942).
Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors.
Review
New
Roskoski, United States. In Pharmacol Res, Apr 2015
The chief phosphorylation sites of human Src include an activating pTyr419 that results from phosphorylation in the kinase domain by an adjacent Src molecule and an inhibitory pTyr530 in the regulatory tail that results from phosphorylation by C-terminal Src kinase (Csk) or Chk (Csk homologous kinase).
Cytotoxicity of the Sesquiterpene Lactones Neoambrosin and Damsin from Ambrosia maritima Against Multidrug-Resistant Cancer Cells.
Efferth et al., Mainz, Germany. In Front Pharmacol, 2014
Immunoblotting and in silico analyses revealed that 1 and 2 silenced c-Src kinase activity.
PAG--a multipurpose transmembrane adaptor protein.
Review
Horejsi et al., Praha, Czech Republic. In Oncogene, 2014
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), also known as Csk-binding protein (Cbp), is a ubiquitously expressed transmembrane adaptor protein present in lipid rafts and involved in a number of signaling pathways.
Redox circuitries driving Src regulation.
Review
Chiarugi et al., Florence, Italy. In Antioxid Redox Signal, 2014
RECENT ADVANCES: Several recent insights have reported that, alongside the well-known phosphorylation/dephosphorylation control, cysteine oxidation is a further mechanism of enzyme activation for both c-Src kinase and its oncogenic counterparts.
Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.
Impact
Weiss et al., San Francisco, United States. In Nat Immunol, 2014
To understand how the kinase Csk, a negative regulator of SFKs, controls the basal state and the initiation of TCR signaling, we generated mice that express a Csk variant sensitive to an analog of the common kinase inhibitor PP1 (Csk(AS)).
Do inhibitory immune receptors play a role in the etiology of autoimmune disease?
Review
Meyaard et al., Utrecht, Netherlands. In Clin Immunol, 2014
In this respect, the finding that genetic variation in CSK and PTPN22 is strongly associated with multiple autoimmune diseases is of interest.
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.
Impact
Gregersen et al., Long Beach, United States. In Nat Genet, 2012
The c-Src tyrosine kinase, Csk, physically interacts with the intracellular phosphatase Lyp (encoded by PTPN22) and can modify the activation state of downstream Src kinases, such as Lyn, in lymphocytes.
Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1.
GeneRIF
Hamel et al., Toronto, Canada. In Dev Biol, 2012
These data demonstrate that expression of an activated allele of c-src overcomes the block to mammary gland morphogenesis in mice arising due to the loss of the cytoplasmic C-terminal domain of Ptch1.
Impaired social memories in 129P2 inbred mice are rescued by reduced Csk expression.
GeneRIF
Roder et al., Toronto, Canada. In Genes Brain Behav, 2012
The Csk pathway appears to be a critical signaling cascade regulating social learning and memory
Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up.
GeneRIF
Martin et al., Granada, Spain. In Hum Mol Genet, 2012
Data provide evidence for replication and overall genome-wide significance for systemic sclerosis (SSc) genetic risk locus: tyrosine-protein kinase CSK with P-value = 5.04 x 10(-12), odds ratio (OR) = 1.20.
The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells.
GeneRIF
Jia et al., Beijing, China. In Mol Cell Biochem, 2012
the association between Furin and its substrate MT1-MMP is regulated by PDGFR stimulation and c-Src.
Stress transmission within the cell.
Review
Wang et al., Boston, United States. In Compr Physiol, 2011
During past decades, it has become evident that the deformable cytoskeleton (CSK), an intracellular network of various filamentous biopolymers, provides a physical basis for transducing mechanical signals into biochemical responses.
Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.
GeneRIF
Lindquist et al., Hannover, Germany. In Plos One, 2010
Data show that the phosphoprotein associated with glycosphigolipid-enriched microdomains (PAG)/Csk binding protein (Cbp) modulates SFK activity in the brain.
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.
Impact
GeneRIF
Weiss et al., San Francisco, United States. In Immunity, 2010
show that relative titration of CD45 and Csk expression reveals distinct regulation of basal and inducible T cell receptor signaling during thymic development.
An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression.
Impact
Cheresh et al., San Diego, United States. In Nat Med, 2009
Pharmacological blockade of c-Src kinase activity or decreased expression of endogenous alpha(v)beta(3) integrin or c-Src not only inhibited anchorage-independent growth but also suppressed metastasis in vivo, yet these manipulations did not affect tumor cell migration or invasion.
Genome-wide association study of blood pressure and hypertension.
Impact
van Duijn et al., Framingham, United States. In Nat Genet, 2009
When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1).
More papers using Csk antibodies
LIME
Supplier
Hořejší Václav et al., In The Journal of Experimental Medicine, 1993
... ) (New England Biolabs, Inc.), Csk (Santa Cruz Biotechnology, Inc.), mAbs to CD3 ...
Histochemistry of silicon in rice plant III. The presence of cuticle-silica double layer in the epidermal tissue
Supplier
Yasui Hajime et al., In Journal of Applied Phycology, 1961
... A calibration of reactive silicate concentrations was conducted using CSK standard solutions (Wako Chemicals, Osaka, Japan) ...
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