Intra- and Intersubunit Dynamic Binding in Kv4.2 Channel Closed-State Inactivation.
Hamburg, Germany. In Biophys J, Feb 2016
We studied the kinetics and structural determinants of closed-state inactivation (CSI) in Kv4.2 channels, considering a multistep process and the possibility that both intra- and intersubunit dynamic binding (i.e., loss and restoration of physical contact) may occur between the S4-S5 linker, including the initial S5 segment (S4S5), and the S6 gate.
Mechanisms of closed-state inactivation in voltage-gated ion channels.
Hamburg, Germany. In J Physiol, 2011
Inactivation may occur from the open state (open-state inactivation, OSI) at strongly depolarized membrane potentials, or from pre-open closed states (closed-state inactivation, CSI) at hyperpolarized and modestly depolarized membrane potentials.