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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Laminin, gamma 2

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: GM-CSF, CAN, HAD, G-CSF, M-CSF
Papers using CsF antibodies
Improved drug-like properties of therapeutic proteins by directed evolution
Minter Ralph et al., In Protein Engineering, Design and Selection, 2009
... Random mutagenesis libraries for EPO and G-CSF were constructed using diversity PCR random mutagenesis kit (Clontech) according to the manufacturer's ...
Integration of host-related signatures with cancer cell-derived predictors for the optimal management of anticancer chemotherapy
de Gruijl Tanja D. et al., In Cancer Immunology, Immunotherapy, 2009
... cells (MUTZ3-LC) were cultured from MUTZ-3 progenitors with 10 ng/ml TGF-β1 (Biovision, Mountain View, CA), 1,000 IU/ml rhGM-CSF (Sagramostim, Berlex), and 120 IU/ml TNFα (Miltenyi Biotec, Bergisch Gladbach, Germany) for ...
Protein mobilization in germinating mung bean seeds involves vacuolar sorting receptors and multivesicular bodies
Sun Samuel SM et al., In BMC Biotechnology, 2006
... Dimerization analysis of hG-CSF expressed in transgenic tobacco leaves and seeds ...
The role of T lymphocytes in bone metabolism
Lovibond A.C. et al., In Biochemical and Biophysical Research Communications, 2004
... Recombinant human M-CSF, soluble human recombinant RANKL, recombinant human OPG, and murine recombinant TGF-β1 were obtained from Insight Biotechnology.
A kinetic study of the murine mixed lymphocyte reaction by 5,6-carboxyfluorescein diacetate succinimidyl ester labeling.
Lowenstein Pedro R., In PLoS ONE, 2002
... against CD3, CD4, CD27, CD28, CD45-RA, CD45-RO, CD57, CD62-L, IL-2, IL-4, IL-5, IL-13, TNF-α, IFN-γ, GM-CSF from BD Biosciences, CD8α, CD8β, TCRαβ, Vβ1, ...
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Papers on CsF
Multiple sclerosis in the very young: a case report and review of the literature.
Moodley et al., Cleveland, United States. In Neurodegener Dis Manag, Feb 2016
Initial cerebrospinal fluid (CSF) studies and MRI of the spine were normal.
Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis.
Hashimoto et al., Chiba, Japan. In Mol Psychiatry, Feb 2016
In this study, we performed metabolomics of cerebrospinal fluid (CSF) from male BD patients (n=54) and age-matched male healthy controls (n=40).
DEL1 - a new player in periodontal disease?
Voronov, Toronto, Canada. In Oral Dis, Feb 2016
Osteoblasts (as well as osteocytes and stromal cells) secrete two key molecules, macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor κB ligand (RANKL), which activate the fusion of the mononuclear precursors to form mature multinucleated osteoclasts.
A Matter of Perspective: Moving from a Pre-omic to a Systems-Biology Vantage of Monocyte-Derived Cell Function and Nomenclature.
Malissen et al., Gent, Belgium. In Immunity, Feb 2016
UNASSIGNED: In response to the comments by Lutz and colleagues to our recent preview of the paper from Helft and colleagues (Helft et al., 2015), we wish to respectfully point out that granulocyte-macrophage colony-stimulating factor (GM-CSF) bone-marrow (BM) cultures have indeed allowed conceptual advances essential for our current understanding of the immunobiology of myeloid cells.
IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo.
Neufert et al., Erlangen, Germany. In Gut, Feb 2016
Mechanistically, IL-36R ligands released upon mucosal damage activated IL-36R(+) colonic fibroblasts via Myd88 thereby inducing expression of chemokines, granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-6.
The cerebral venous system and the postural regulation of intracranial pressure: implications in the management of patients with cerebrospinal fluid diversion.
Sood et al., Sacramento, United States. In Childs Nerv Syst, Feb 2016
UNASSIGNED: Loss of cerebrospinal fluid (CSF) occurs commonly in daily neurosurgical practice.
Cerebrospinal fluid neurogranin and YKL-40 as biomarkers of Alzheimer's disease.
Hansson et al., Malmö, Sweden. In Ann Clin Transl Neurol, Jan 2016
OBJECTIVE: Widespread implementation of cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) in clinical settings requires improved accuracy for diagnosis of prodromal disease and for distinguishing AD from non-AD dementias.
The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research.
Wekerle et al., München, Germany. In Lancet Neurol, Jan 2016
UNASSIGNED: Interest in CD8+ T cells and B cells was initially inspired by observations in multiple sclerosis rather than in animal models: CD8+ T cells predominate in multiple sclerosis lesions, oligoclonal immunoglobulin bands in CSF have long been recognised as diagnostic and prognostic markers, and anti-B-cell therapies showed considerable efficacy in multiple sclerosis.
Young investigator challenge: Cytomorphologic analysis of cerebrospinal fluid in 70 pediatric patients with medulloblastoma and review of the literature focusing on novel diagnostic and prognostic tests.
Vielh et al., Villejuif, France. In Cancer Cytopathol, Nov 2015
This objective of this study was to describe the cytomorphologic features of MB in cerebrospinal fluid (CSF).
Neutrophil ageing is regulated by the microbiome.
Frenette et al., New York City, United States. In Nature, Oct 2015
Aged neutrophils upregulate CXCR4, a receptor allowing their clearance in the bone marrow, with feedback inhibition of neutrophil production via the IL-17/G-CSF axis, and rhythmic modulation of the haematopoietic stem-cell niche.
The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.
Becher et al., Zürich, Switzerland. In Immunity, Oct 2015
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine produced by auto-reactive T helper (Th) cells that initiate tissue inflammation.
Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome.
Chilvers et al., Cambridge, United Kingdom. In Lancet, Mar 2015
METHODS: GeneChip Affymetrix oligonucleotide arrays were used to assess global transcriptional profiles in highly pure PMNs from ventilated patients fulfilling the Berlin ARDS definition (n=10), in freshly isolated PMNs from age-matched and sex-matched healthy volunteers (n=10), and in healthy volunteer PMNs exposed in vitro to recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) (1 ng/mL for 6 h).
Understanding How the Subcommissural Organ and Other Periventricular Secretory Structures Contribute via the Cerebrospinal Fluid to Neurogenesis.
Rodríguez et al., Valdivia, Chile. In Front Cell Neurosci, 2014
The dynamic and molecular composition of the cerebrospinal fluid (CSF) and, consequently, the CSF physiology is much more complex and fascinating than the simplistic view held for decades.
The importance of the granulocyte-colony stimulating factor in oncology.
Oprean et al., Cluj-Napoca / Kolozsvár, Romania. In Clujul Med, 2014
Granulocyte-colony stimulating factor (G-CSF) is a glycoprotein, the second CSF, sharing some common effects with granulocyte macrophage-colony stimulating factor (GM-CSF), interleukin-3 (IL-3) and interleukin-5 (IL-5).
The Human Experience with Intravenous Levodopa.
Black et al., Saint Louis, United States. In Front Pharmacol, 2014
At least 2760 subjects have received IV levodopa, and reported outcomes include parkinsonian signs, sleep variables, hormone levels, hemodynamics, CSF amino acid composition, regional cerebral blood flow, cognition, perception and complex behavior.
Immunohistochemical expression profile of β-catenin, E-cadherin, P-cadherin, laminin-5γ2 chain, and SMAD4 in colorectal serrated adenocarcinoma.
Pérez-Guillermo et al., Cartagena, Spain. In Hum Pathol, 2012
Compared with conventional carcinomas, serrated adenocarcinomas showed significantly increased cytoplasmic expression of laminin-5gamma2 at the invasive front that was particularly pronounced in the tumor buds.
An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis.
Kikuchi et al., Suita, Japan. In Mol Cancer Ther, 2012
Data suggest that an anti-Wnt5a antibody was capable of suppressing Wnt5a-dependent internalization of Fz2 receptor, resulting in the prevention of metastasis of gastric cancer cells by inhibiting the activation of Rac1 and the expression of laminin gamma2.
Polymerized laminin-332 matrix supports rapid and tight adhesion of keratinocytes, suppressing cell migration.
Miyazaki et al., Yokohama, Japan. In Plos One, 2011
Data show laminin-332 (alpha3ss3gamma2)(Lm332) matrix supported adhesion of keratinocytes much more strongly and stably than purified Lm332.
Expression of laminin-5 γ2 chain in cutaneous pseudocarcinomatous hyperplasia.
de Magalhães et al., Brasília, Brazil. In J Cutan Pathol, 2011
Cytoplasmic laminin-5 expression should not be used as a criterion of malignancy and is not useful in distinguishing pseudocarcinomatous hyperplasia from microinvasive and well-differentiated SCC.
Immunohistochemical analysis of laminin 5-γ2 chain expression for differentiation of basal cell carcinoma from trichoblastoma.
Nabeshima et al., In Histopathology, 2011
Immunohistochemical analysis of laminin 5-gamma2 chain expression for differentiation of basal cell carcinoma from trichoblastoma.
More papers using CsF antibodies
Hepatosplenic γ/δ T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 cases
Ruiz Phillip et al., In Journal of Medical Case Reports, 2002
... DNA was purified from the CSF using Qiamp spin columns (Qiagen, Inc ...
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
Unutmaz Derya, In PLoS ONE, 2002
... (Vα24Jα18 specific) and mAbs specific for human CD3, CD4, CD8α, CD19, CD40L (CD154), CD56, CD69, GM-CSF & IFNγ were obtained from BD Biosciences.
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture
Brugge Joan S. et al., In The Journal of Cell Biology, 1998
... Labs; Ki-67 from Zymed Laboratories; phospho-Src(Y416) from New England Biolabs, Inc.; and cleaved caspase-3 and phospho-CSF-1R(Y723) from Cell Signaling Technologies ...
Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice
Pollard Jeffrey W. et al., In The Journal of Experimental Medicine, 1997
... The preparation and genotyping of CSF-1–transgenic mice (MMTV/tetracycline activator [Ta] ...
Strukturiertes Klinisches Interview für DSM-IV.
Baune Bernhard, In PLoS ONE, 1996
... Glucose levels in CSF and serum from healthy subjects, IPS and schizophrenic patients were measured immediately after collection using a NOVA BioProfile analyzer (Nova Biomedical, Waltham, USA) ...
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase
Virgin Herbert W. et al., In PLoS Biology, 1994
... 100 U penicillin/ml, 100 μg/ml streptomycin, 1% nonessential amino acids (Biosource), and 20 ng/ml recombinant mouse GM-CSF (BD Biosciences, San Jose, California, United ...
Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor
Nerurkar Pratibha V., In PLoS ONE, 1993
... Anti-G-CSF antibody was obtained from BioLegend (San Diego, CA, USA) ...
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