Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML)
In PLoS ONE, 2009
... (LEHD, 1 h, 20 µM), IETD-cho (IETD, 1 h, 20 µM) from Alexis Biochemicals (Lausen, Switzerland), cyclosporine A (CsA, 15 min, 1 µM), calpeptin (1 h, 250 µM), bapta-AM (1h, 10 µM) from Biomol (Plymouth Meeting, PA, USA), ...
Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway.
Nantong, China. In Front Biosci, Dec 2015
Results showed that phenylephrine promoted CF proliferation, which was abolished by α1-adrenergic receptor antagonist (prazosin), a blocker of Ca(+2) influx (nifedipine), an intracellular Ca(2+) buffer (BAPTA-AM), CaN inhibitors (cyclosporin A and FK506), and over-expression of dominant negative CaN. Phenylephrine activated CaN and evoked NFAT3 nuclear translocation, both of which were blocked by cyclosporine A (CsA) or over-expression of dominant negative CaN.
Systemic cyclosporine and corneal transplantation.
Manchester, United Kingdom. In Int Ophthalmol, Nov 2015
One of the most promising immunomodulatory substances whose immunosuppressive effect has revolutionized solid organ transplantation is cyclosporine (CsA).