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Defensin, alpha, 6

cryptdin 2
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Top mentioned proteins: Defensin, Neuropilin-1, ACID, Lysozyme, SOD
Papers on cryptdin 2
Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide.
New
Hornef et al., Hannover, Germany. In Gut, Feb 2015
DESIGN: The anatomical distribution as well as antibacterial and anti-inflammatory activity of the endogenous AMP cryptdin 2 and the synthetic peptide Pep19-2.5 at the enteric mucosal surface were analysed by immunostaining, functional viability and stimulation assays, an oral Salmonella enterica subsp.
In vitro and in vivo synergistic effects of cryptdin 2 and ampicillin against Salmonella.
Verma et al., Chandīgarh, India. In Antimicrob Agents Chemother, 2011
To reduce the dose of antibiotic required in order to decrease the associated side effects, the present study was aimed at evaluating the synergism between cryptdin 2 (a Paneth cell antimicrobial peptide) and ampicillin (Amp) against Salmonella enterica serovar Typhimurium.
Postnatal changes in the expression of genes for cryptdins 1-6 and the role of luminal bacteria in cryptdin gene expression in mouse small intestine.
Yajima et al., Sapporo, Japan. In Fems Immunol Med Microbiol, 2008
Interestingly, the difference in the gene expression for cryptdin 2, 4 and 5 between the jejunum and ileum seemed to be increased by the presence of the luminal bacteria.
Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms.
Selsted et al., Boston, United States. In Infect Immun, 1994
In a bactericidal assay system, cryptdins 1 and 3 to 6 were equally active at 10 micrograms/ml but cryptdin 2 and rabbit NP-1 were not active at this concentration.
Paneth cell differentiation in the developing intestine of normal and transgenic mice.
Gordon et al., Saint Louis, United States. In Proc Natl Acad Sci U S A, 1994
Transgenic mice containing nucleotides -6500 to +34 of the Paneth cell-specific mouse cryptdin 2 gene linked to the human growth hormone gene beginning at its nucleotide +3 inappropriately express human growth hormone in a large population of proliferating and nonproliferating cells in the intervillus epithelium up to postnatal day 5. Transgene expression subsequently becomes restricted to the Paneth cell lineage in the developing crypt.
Cryptdins: antimicrobial defensins of the murine small intestine.
Lehrer et al., In Infect Immun, 1992
We purified two closely related defensins, cryptdin 1 and cryptdin 2, from a subcellular fraction of murine small intestine cells that was enriched in Paneth cells.
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