GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Crystallin, mu
CRYM, THBP
Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010] (from
NCBI)
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Papers using
CRYM
antibodies
Accurate whole human genome sequencing using reversible terminator chemistry
Supplier
In BMC Developmental Biology, 2007
... Optical section of Tg(Crym-EGFP)82Gsat/Mmcd transgenic mouse kidney ...
Papers on
CRYM
μ-Crystallin controls muscle function through thyroid hormone action.
New
Nagasaki, Japan. In Faseb J, Jan 2016
UNASSIGNED: μ-Crystallin (Crym), a thyroid hormone-binding protein, is abnormally up-regulated in the muscles of patients with facioscapulohumeral muscular dystrophy, a dominantly inherited progressive myopathy.
Ketimine reductase/CRYM catalyzes reductive alkylamination of α-keto acids, confirming its function as an imine reductase.
New
Port Macquarie, Australia. In Amino Acids, Nov 2015
Recently, crystalized mouse ketimine reductase/CRYM complexed with NADPH was found to have pyruvate bound in its active site.
Regulation of thyroid hormone-induced development in vivo by thyroid hormone transporters and cytosolic binding proteins.
New
Cincinnati, United States. In Gen Comp Endocrinol, Nov 2015
We used a combination of expression pattern, relative expression level, and in vivo functional analysis to evaluate the potential for THTs (LAT1, OATP1c1, and MCT8) and CTHBPs (PKM2, CRYM, and ALDH1) to control the timing of TH-dependent development.
Biomaterial bridges enable regeneration and re-entry of corticospinal tract axons into the caudal spinal cord after SCI: Association with recovery of forelimb function.
New
Irvine, United States. In Biomaterials, Oct 2015
In order to detect regeneration of descending neuronal tracts into the bridge, and beyond into intact caudal parenchyma, we developed a mouse cervical implantation model and employed Crym:GFP transgenic mice.
Right ventricular protein expression profile in end-stage heart failure.
New
Nashville, United States. In Pulm Circ, Sep 2015
In all 12 hearts, the right ventricles (RVs) demonstrated differential expression of 11 proteins relative to the left ventricles (LVs), including lesser expression of CRYM, TPM1, CLU, TXNL1, and COQ9 and greater expression of TNNI3, SAAI, ERP29, ACTN2, HSPB2, and NDUFS3.
Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions.
New
Sydney, Australia. In Neurochem Res, Jun 2015
Mammalian ketimine reductase is identical to μ-crystallin (CRYM)-a protein that is also an important thyroid hormone binding protein.
Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease.
New
Fontenay-aux-Roses, France. In Hum Mol Genet, Apr 2015
Here, we studied the striatal protein µ-crystallin (Crym).
Follicular thyroglobulin enhances gene expression necessary for thyroid hormone secretion.
Tokyo, Japan. In Endocr J, 2014
In the present study, we examined the potential effect of follicular Tg on TH transport and secretion by quantifying the expression of two TH transporters: monocarboxylate transporter 8 (MCT8) and μ-crystallin (CRYM).
Deafness gene expression patterns in the mouse cochlea found by microarray analysis.
Matsumoto, Japan. In Plos One, 2013
The most remarkable finding was a gradient of gene expression changes in four genes (Pou4f3, Slc17a8, Tmc1, and Crym) whose mutations cause autosomal dominant deafness.
Cytosolic T3-binding protein modulates dynamic alteration of T3-mediated gene expression in cells.
Matsumoto, Japan. In Endocr J, 2013
μ-Crystallin (CRYM) is also known as NADPH-dependent cytosolic T3-binding protein.
Lysine metabolism in mammalian brain: an update on the importance of recent discoveries.
Review
Port Macquarie, Australia. In Amino Acids, 2013
The discovery that this KR, which is capable of reducing not only P2C but also other cyclic imines, is identical to a previously well-described thyroid hormone-binding protein [μ-crystallin (CRYM)], may hold the key to understanding the biological relevance of the pipecolate pathway and its importance in the brain.
KIBRA gene polymorphism has no association with verbal or visual episodic memory performance.
Hobart, Australia. In Front Aging Neurosci, 2013
A total of 256 female and 130 male healthy, older adults (mean age = 60.86 years) were recruited from the Tasmanian Healthy Brain Project (THBP), undergoing both neuropsychological and genetic testing.
Mammalian forebrain ketimine reductase identified as μ-crystallin; potential regulation by thyroid hormones.
GeneRIF
Port Macquarie, Australia. In J Neurochem, 2011
The purified human mu-crystallin was confirmed to have ketimine reductase activity with a maximum specific activity similar to that of native ovine ketimine reductase
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
GeneRIF
München, Germany. In J Psychiatr Res, 2010
This protein has been found differentially expressed in thalami from patients with schizophrenia.
{mu}-Crystallin, new candidate protein in endotoxin-induced uveitis.
GeneRIF
Matsumoto, Japan. In Invest Ophthalmol Vis Sci, 2010
CRYM plays an important role in the development of the second peak of murine EIU.
Hyperglycemia induces elevated expression of thyroid hormone binding protein in vivo in kidney and heart and in vitro in mesangial cells.
GeneRIF
London, United Kingdom. In Biochem Biophys Res Commun, 2010
This is the first report linking hyperglycemia with thyroid hormone binding protein CRYM and suggests that the role of CRYM in diabetic complications should be further investigated.
Identification of mu-crystallin as an androgen-regulated gene in human prostate cancer.
GeneRIF
Innsbruck, Austria. In Prostate, 2009
CRYM is a novel androgen-regulated gene whose expression is elevated in prostate cancer but down-regulated in castration therapy-resistant tumors.
Genetics of crystallins: cataract and beyond.
Review
München, Germany. In Exp Eye Res, 2009
The mu- and zeta-crystallins (gene symbols: Crym and Cryz, respectively) are discussed as examples for mammals.
The responsible genes in Japanese deafness patients and clinical application using Invader assay.
Review
Matsumoto, Japan. In Acta Otolaryngol, 2008
Also, mutations in KCNQ4, TECTA, COCH, WFS1, CRYM, COL9A3, and KIAA1199 were found in independent autosomal dominant families.
Fluorescence-line-narrowed spectra of polycyclic aromatic carcinogen-DNA adducts.
Impact
In Science, 1984
Comparisons were made between the spectrum of this modified DNA and the isolated deoxyguanosine-BPDE adduct and a series of other 7,8,9,10-tetrahydro-BP (THBP) derivatives.
