GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 05 Jun 2013.
Cone-rod homeobox
CRX
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
CRX
Prioritization of retinal disease genes: an integrative approach.
New
Iowa City, United States. In Hum Mutat, 30 Jun 2013
To approach this problem, we generate a set of feature vectors from publicly available microarray, RNA-seq, and ChIP-seq datasets of biological relevance to retinal disease, to observe patterns in gene expression specificity among tissues of the body and the eye, in addition to photoreceptor-specific signals by the CRX transcription factor.
Developing rods transplanted into the degenerating retina of crx-knockout mice exhibit neural activity similar to native photoreceptors.
New
Kōbe, Japan. In Stem Cells, 30 Jun 2013
A proportion of grafted rods develop rhodopsin-positive outer segment-like structures within 2 weeks after transplantation into the retina of Crx-knockout mice and produce rectifier outward current and Ih upon membrane depolarization and hyperpolarization.
Comprehensive mutation analysis by whole-exome sequencing in 41 Chinese families with Leber congenital amaurosis.
New
Guangzhou, China. In Invest Ophthalmol Vis Sci, 09 Jun 2013
In these 12 families with identified mutations, mutations were found in CEP290 (three probands); GUCY2D (two probands); and CRB1, CRX, RPE65, IQCB1, LCA5, TULP1, and IMPDH1 (one proband each).
Photoreceptor-like cells from reprogramming cultured mammalian RPE cells.
New
Birmingham, United States. In Mol Vis, Dec 2012
The new cells expressed genes encoding photoreceptor proteins, including interphotoreceptor retinoid-binding protein IRBP), recoverin, retinal cone arrestin 3, transducin α-subunit, Cone-rod homeobox protein (Crx), and red opsin.
Ablation of C/EBP Homologous Protein Does Not Protect T17M RHO Mice from Retinal Degeneration.
New
Fort Worth, United States. In Plos One, Dec 2012
These mice had significant reduction in the expression of transcription factors, Crx and Nrl, and also in mouse Rho, and human RHO.
Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina.
New
Regensburg, Germany. In Plos One, Dec 2012
The majority of these genes is under the control of the transcription factor Cone rod homeobox (Crx), that acts as a master transcription factor in photoreceptors.
[Molecular-cellular mechanisms of retina pathology development in people of various age].
Review
In Adv Gerontol, 2011
Mutations in the CRX gene are the cause of progressive states such as cone-rod dystrophy.
Crx broadly modulates the pineal transcriptome.
GeneRIF
Copenhagen, Denmark. In J Neurochem, 2011
Crx broadly modulates the pineal transcriptome and also influences differential night/day gene expression in this tissue
No interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.
GeneRIF
Bethesda, United States. In Plos One, 2010
Data show no interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.
CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors.
GeneRIF
Saint Louis, United States. In Genome Res, 2010
CRX combinatorially orchestrates the transcriptional networks of both rods and cones by coordinating the expression of photoreceptor genes including most retinal disease genes.
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.
Review
Impact
Bethesda, United States. In Nat Rev Neurosci, 2010
Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate.
A neuroanatomical and physiological study of the non-image forming visual system of the cone-rod homeobox gene (Crx) knock out mouse.
GeneRIF
Copenhagen, Denmark. In Brain Res, 2010
A change in the suprachiasmatic nuclei of the Crx-deficient mouse might explain the observed circadian differences between the knockout mouse and wild-type mouse.
Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes.
GeneRIF
Suita, Japan. In Febs Lett, 2010
Studies isolated Panky/Ankrd33, a gene encoding an ankyrin repeat-containing protein and that PANKY inhibited the DNA-binding activity of CRX.
Leber congenital amaurosis: genes, proteins and disease mechanisms.
Review
Nijmegen, Netherlands. In Prog Retin Eye Res, 2008
The LCA genes encode proteins with a wide variety of retinal functions, such as photoreceptor morphogenesis (CRB1, CRX), phototransduction (AIPL1, GUCY2D), vitamin A cycling (LRAT, RDH12, RPE65), guanine synthesis (IMPDH1), and outer segment phagocytosis (MERTK).
Regulation of photoreceptor gene expression by Crx-associated transcription factor network.
Review
Saint Louis, United States. In Brain Res, 2008
This regulation is mediated by a network of photoreceptor transcription factors centered on Crx, an Otx-like homeodomain transcription factor.
Genotype-phenotype correlation in a German family with a novel complex CRX mutation extending the open reading frame.
Review
GeneRIF
Regensburg, Germany. In Ophthalmology, 2007
description of a 2-generation family with a novel mutation in CRX; the resulting phenotype is that of cone-rod dystrophy with variable age at onset and progression
Otx5 regulates genes that show circadian expression in the zebrafish pineal complex.
Impact
Baltimore, United States. In Nat Genet, 2002
The gene cone rod homeobox (crx), a member of the orthodenticle homeobox (otx) family, is thought to regulate pineal circadian activity.
Nrl is required for rod photoreceptor development.
Impact
Ann Arbor, United States. In Nat Genet, 2001
It acts synergistically with Crx to regulate rhodopsin transcription.
Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis.
Impact
Houston, United States. In Nat Genet, 2000
4) and CRX (ref.
Retinopathy and attenuated circadian entrainment in Crx-deficient mice.
Impact
Boston, United States. In Nat Genet, 1999
Crx, an Otx-like homeobox gene, is expressed specifically in the photoreceptors of the retina and the pinealocytes of the pineal gland.
