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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Sep 2015.

Cone-rod homeobox

The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ROD, Rhodopsin, CAN, LCa, Otx2
Papers on CRX
Experimental TLR4 inhibition improves intestinal microcirculation in endotoxemic rats.
Lehmann et al., Halifax, Canada. In Microvasc Res, 30 Sep 2015
MATERIALS AND METHODS: The intestinal microcirculation was studied by intravital microscopy in four groups of Lewis rats (n=10 per group): healthy controls (CON group), endotoxemic animals (15mg/kg lipopolysaccharide, LPS group), endotoxemic animals treated with a TLR4 antagonist (1mg/kg CRX-526, LPS+CRX526 group), and controls treated with CRX-526 (C-CRX526 group).
LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor.
Barnstable et al., Penn Hills, United States. In Mol Neurobiol, 23 Sep 2015
The inhibition of rod photoreceptor gene expression occurred in spite of the normal expression of transcription factors CRX and NRL, and the normal accumulation of H3K4me2 marks over the promoter and gene body.
Characterization of three-dimensional retinal tissue derived from human embryonic stem cells in adherent monolayer cultures.
Nasonkin et al., Pittsburgh, United States. In Stem Cells Dev, 18 Sep 2015
We found that deriving such tissue in adherent conditions robustly induces all eye field genes (RX, PAX6, LHX2, SIX3, SIX6) and produces four layers of pure populations of retinal cells: RPE (expressing NHERF1, EZRIN, RPE65, DCT, TYR, TYRP, MITF, PMEL), early photoreceptors (coexpressing CRX and RCVRN), inner nuclear layer neurons (expressing CALB2) and retinal ganglion cells (RGCs, expressing BRN3B and Neurofilament [NF] 200).
Rax Homeoprotein Regulates Photoreceptor Cell Maturation and Survival in Association with Crx in the Postnatal Mouse Retina.
Furukawa et al., Kyoto, Japan. In Mol Cell Biol, 01 Sep 2015
In luciferase assays, we found that Rax and Crx cooperatively transactivate Rhodopsin and cone opsin promoters and that an optimum Rax expression level to transactivate photoreceptor gene expression exists.
PCB1254 exposure contributes to the abnormalities of optomotor responses and influence of the photoreceptor cell development in zebrafish larvae.
Tong et al., Nanjing, China. In Ecotoxicol Environ Saf, 31 Aug 2015
The mRNA expression of the CRX, RHO, SWS1, and SWS2 was assessed by the Quantitative Real-Time PCR.
Transcriptome dynamics of developing photoreceptors in 3-D retina cultures recapitulates temporal sequence of human cone and rod differentiation revealing cell surface markers and gene networks.
Swaroop et al., Tokyo, Japan. In Stem Cells, 31 Aug 2015
We have generated a H9 human embryonic stem cell subclone that carries a GFP reporter under the control of the promoter of cone-rod homeobox (CRX), an established marker of post-mitotic photoreceptor precursors.
Mechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathies.
Chen et al., Saint Louis, United States. In Dev Dyn, Oct 2014
BACKGROUND: The homeodomain transcription factor CRX is a crucial regulator of mammalian photoreceptor gene expression.
Homeobox genes and melatonin synthesis: regulatory roles of the cone-rod homeobox transcription factor in the rodent pineal gland.
Rath et al., Copenhagen, Denmark. In Biomed Res Int, 2013
Among these, the cone-rod homeobox (CRX) transcription factor is believed to control pineal-specific Aanat expression.
FAM161A, a novel centrosomal-ciliary protein implicated in autosomal recessive retinitis pigmentosa.
Stöhr et al., Regensburg, Germany. In Adv Exp Med Biol, 2013
Homozygous and compound heterozygous null mutations in the CRX-regulated FAM161A gene of unknown function were identified as a cause for autosomal recessive RP (RP28) in patients from India, Germany, Israel, the Palestinian territories, and the USA.
Immunohistochemical expression of CRX in extracranial malignant small round cell tumors.
Perez-Atayde et al., Boston, United States. In Am J Surg Pathol, 2012
These findings suggest that CRX is a useful marker to discriminate metastatic retinoblastoma from other, more common, malignant small round cell tumors of childhood
Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysis.
Swaroop et al., Bethesda, United States. In Plos Genet, 2011
Our results show that NRL and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis-regulatory module
Derivation of human differential photoreceptor-like cells from the iris by defined combinations of CRX, RX and NEUROD.
Umezawa et al., Japan. In Plos One, 2011
Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation.
[Molecular-cellular mechanisms of retina pathology development in people of various age].
D'iakonov et al., In Adv Gerontol, 2011
Mutations in the CRX gene are the cause of progressive states such as cone-rod dystrophy.
Crx broadly modulates the pineal transcriptome.
Klein et al., Copenhagen, Denmark. In J Neurochem, 2011
Crx broadly modulates the pineal transcriptome and also influences differential night/day gene expression in this tissue
No interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.
Craigie et al., Bethesda, United States. In Plos One, 2010
Data show no interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.
Forrest et al., Bethesda, United States. In Nat Rev Neurosci, 2010
Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate.
Otx5 regulates genes that show circadian expression in the zebrafish pineal complex.
Liang et al., Baltimore, United States. In Nat Genet, 2002
The gene cone rod homeobox (crx), a member of the orthodenticle homeobox (otx) family, is thought to regulate pineal circadian activity.
Nrl is required for rod photoreceptor development.
Swaroop et al., Ann Arbor, United States. In Nat Genet, 2001
It acts synergistically with Crx to regulate rhodopsin transcription.
Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis.
Daiger et al., Houston, United States. In Nat Genet, 2000
4) and CRX (ref.
Retinopathy and attenuated circadian entrainment in Crx-deficient mice.
Cepko et al., Boston, United States. In Nat Genet, 1999
Crx, an Otx-like homeobox gene, is expressed specifically in the photoreceptors of the retina and the pinealocytes of the pineal gland.
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