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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 10 Nov 2015.

Cone-rod homeobox

The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ROD, Rhodopsin, CAN, LCa, Otx2
Papers on CRX
PEG modified liposomes containing CRX-601 adjuvant in combination with methylglycol chitosan enhance the murine sublingual immune response to influenza vaccination.
Burkhart et al., Hamilton, United States. In J Control Release, 06 Dec 2015
Herein we demonstrate a robust immune response against influenza antigens co-delivered sublingually with engineered liposomes carrying the synthetic Toll-like receptor-4 agonist, CRX-601.
OTX2 is a therapeutic target for retinoblastoma and may function as a common factor between C-MYC, CRX, and phosphorylated RB pathways.
Adamson et al., Durham, United States. In Int J Oncol, 30 Nov 2015
Loss of OTX2 expression also resulted in decreased expression of C-MYC and CRX, genes previously implicated in retinoblastoma tumorigenesis.
Methylglycol chitosan and a synthetic TLR4 agonist enhance immune responses to influenza vaccine administered sublingually.
Evans et al., Hamilton, United States. In Vaccine, 26 Nov 2015
We evaluated the efficacy of methylglycol chitosan (MGC) and a synthetic toll-like receptor 4 agonist (CRX-601), alone or in combination, for improving systemic and mucosal immune responses to a monovalent detergent-split flu virus vaccine delivered SL.
Comprehensive interactome of Otx2 in the adult mouse neural retina.
Lamonerie et al., Nice, France. In Genesis, 01 Nov 2015
In this tissue, Otx2 is thought to have overlapping function with its paralog Crx.
Graded gene expression changes determine phenotype severity in mouse models of CRX-associated retinopathies.
Chen et al., Saint Louis, United States. In Genome Biol, Dec 2014
BACKGROUND: Mutations in the cone-rod-homeobox protein CRX are typically associated with dominant blinding retinopathies with variable age of onset and severity.
New COL6A6 variant detected by whole-exome sequencing is linked to break points in intron 4 and 3'-UTR, deleting exon 5 of RHO, and causing adRP.
Carballo et al., Barcelona, Spain. In Mol Vis, Dec 2014
We used a newly devised multiplex PCR assay capable of amplifying the genetic loci of RHO, PRPH2, RP1, PRPF3, PRPF8, PRPF31, IMPDH1, NRL, CRX, KLHL7, and NR2E3 to molecularly diagnose 18 index patients with adRP.
Mechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathies.
Chen et al., Saint Louis, United States. In Dev Dyn, Oct 2014
BACKGROUND: The homeodomain transcription factor CRX is a crucial regulator of mammalian photoreceptor gene expression.
Homeobox genes and melatonin synthesis: regulatory roles of the cone-rod homeobox transcription factor in the rodent pineal gland.
Rath et al., Copenhagen, Denmark. In Biomed Res Int, 2013
Among these, the cone-rod homeobox (CRX) transcription factor is believed to control pineal-specific Aanat expression.
FAM161A, a novel centrosomal-ciliary protein implicated in autosomal recessive retinitis pigmentosa.
Stöhr et al., Regensburg, Germany. In Adv Exp Med Biol, 2013
Homozygous and compound heterozygous null mutations in the CRX-regulated FAM161A gene of unknown function were identified as a cause for autosomal recessive RP (RP28) in patients from India, Germany, Israel, the Palestinian territories, and the USA.
Immunohistochemical expression of CRX in extracranial malignant small round cell tumors.
Perez-Atayde et al., Boston, United States. In Am J Surg Pathol, 2012
These findings suggest that CRX is a useful marker to discriminate metastatic retinoblastoma from other, more common, malignant small round cell tumors of childhood
Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysis.
Swaroop et al., Bethesda, United States. In Plos Genet, 2011
Our results show that NRL and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis-regulatory module
Derivation of human differential photoreceptor-like cells from the iris by defined combinations of CRX, RX and NEUROD.
Umezawa et al., Japan. In Plos One, 2011
Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation.
[Molecular-cellular mechanisms of retina pathology development in people of various age].
D'iakonov et al., In Adv Gerontol, 2011
Mutations in the CRX gene are the cause of progressive states such as cone-rod dystrophy.
Crx broadly modulates the pineal transcriptome.
Klein et al., Copenhagen, Denmark. In J Neurochem, 2011
Crx broadly modulates the pineal transcriptome and also influences differential night/day gene expression in this tissue
No interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.
Craigie et al., Bethesda, United States. In Plos One, 2010
Data show no interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.
Forrest et al., Bethesda, United States. In Nat Rev Neurosci, 2010
Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate.
Otx5 regulates genes that show circadian expression in the zebrafish pineal complex.
Liang et al., Baltimore, United States. In Nat Genet, 2002
The gene cone rod homeobox (crx), a member of the orthodenticle homeobox (otx) family, is thought to regulate pineal circadian activity.
Nrl is required for rod photoreceptor development.
Swaroop et al., Ann Arbor, United States. In Nat Genet, 2001
It acts synergistically with Crx to regulate rhodopsin transcription.
Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis.
Daiger et al., Houston, United States. In Nat Genet, 2000
4) and CRX (ref.
Retinopathy and attenuated circadian entrainment in Crx-deficient mice.
Cepko et al., Boston, United States. In Nat Genet, 1999
Crx, an Otx-like homeobox gene, is expressed specifically in the photoreceptors of the retina and the pinealocytes of the pineal gland.
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