Gene Regulation: It Matters Who You Hang Out With.
Baltimore, United States. In Neuron, 08 May 2015
(2015) demonstrate that myocyte enhancer factor 2D (MEF2D) binds and activates retina-specific regulatory regions by cooperative interaction with the tissue-specific transcription factor CRX.
Induction of ectopic retina-like tissue by transgenic expression of neurogenin.
Birmingham, United States. In Plos One, Dec 2014
The ectopic retina-like tissue contained cells positive for photoreceptor proteins Crx, recoverin, red opsin, and rhodopsin, and cells positive for proteins that label other types of retinal neurons, including AP2α and Pax6 for amacrine cells, Otx2 for bipolar cells, and Brn3A for ganglion cells.
Leber congenital amaurosis: genes, proteins and disease mechanisms.
Nijmegen, Netherlands. In Prog Retin Eye Res, 2008
The LCA genes encode proteins with a wide variety of retinal functions, such as photoreceptor morphogenesis (CRB1, CRX), phototransduction (AIPL1, GUCY2D), vitamin A cycling (LRAT, RDH12, RPE65), guanine synthesis (IMPDH1), and outer segment phagocytosis (MERTK).