Transplantation of Photoreceptors Derived From Human Muller Glia Restore Rod Function in the P23H Rat.
London, United Kingdom. In Stem Cells Transl Med, 01 Mar 2014
This study aimed to differentiate hMSCs into photoreceptor cells by stimulation with growth and differentiation factors in vitro to upregulate gene and protein expression of CRX, NR2E3, and rhodopsin and various phototransduction markers associated with rod photoreceptor development and function and to examine the effect of subretinal transplantation of these cells into the P23H rat, a model of primary photoreceptor degeneration.
Leber congenital amaurosis: genes, proteins and disease mechanisms.
Nijmegen, Netherlands. In Prog Retin Eye Res, 2008
The LCA genes encode proteins with a wide variety of retinal functions, such as photoreceptor morphogenesis (CRB1, CRX), phototransduction (AIPL1, GUCY2D), vitamin A cycling (LRAT, RDH12, RPE65), guanine synthesis (IMPDH1), and outer segment phagocytosis (MERTK).