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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 Mar 2014.

Cone-rod homeobox

CRX
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ROD, Rhodopsin, CAN, LCa, Otx2
Papers on CRX
Analytical and experimental performance evaluation of an integrated Si-photonic balanced coherent receiver in a colorless scenario.
New
Plant et al., In Opt Express, 10 Apr 2014
We study analytically and experimentally the performance limits of a Si-photonic (SiP) balanced coherent receiver (CRx) co-packaged with transimpedance amplifiers (TIAs) in a colorless WDM scheme.
Is CRX protein a useful marker in differential diagnosis of tumors of pineal region?
New
Giangaspero et al., In Pediatr Dev Pathol, 20 Mar 2014
UNLABELLED: Abstract The cone-rod homeobox (Crx) is a gene belongs to the member of the orthodenticle homeobox (Otx) family, with important function in development and differentiation of retinal and pineal cells.
Otx2 ChIP-seq Reveals Unique and Redundant Functions in the Mature Mouse Retina.
New
Lamonerie et al., Nice, France. In Plos One, Dec 2013
Surprisingly, photoreceptor survival does not require Otx2 expression in the neural retina, where the related Crx homeobox gene, a major regulator of photoreceptor development, is also expressed.
FAM161A, a Novel Centrosomal-Ciliary Protein Implicated in Autosomal Recessive Retinitis Pigmentosa.
New
Stöhr et al., Regensburg, Germany. In Adv Exp Med Biol, Dec 2013
Homozygous and compound heterozygous null mutations in the CRX-regulated FAM161A gene of unknown function were identified as a cause for autosomal recessive RP (RP28) in patients from India, Germany, Israel, the Palestinian territories, and the USA.
RETINA-Specific Expression of Kcnv2 Is Controlled by Cone-Rod Homeobox (Crx) and Neural Retina Leucine Zipper (Nrl).
New
Langmann et al., Köln, Germany. In Adv Exp Med Biol, Dec 2013
Using bioinformatic prediction and chromatin immunoprecipitation (ChIP), we identified two Crx binding sites (CBS) and one Nrl binding site (NBS) in the Kcnv2 promoter.
Cell type-specific epigenetic signatures accompany late stages of mouse retina development.
New
Zhang et al., United States. In Adv Exp Med Biol, Dec 2013
Comparison of our genome-wide chromatin signature maps with available data sets for Polymerase-II (Pol-II) and CRX binding sites and DNase1 Hypersensitive Sites (DHS) for retina shows great agreement.
Immunohistochemical expression of CRX in extracranial malignant small round cell tumors.
GeneRIF
Perez-Atayde et al., Boston, United States. In Am J Surg Pathol, 2012
These findings suggest that CRX is a useful marker to discriminate metastatic retinoblastoma from other, more common, malignant small round cell tumors of childhood
Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysis.
GeneRIF
Swaroop et al., Bethesda, United States. In Plos Genet, 2011
Our results show that NRL and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis-regulatory module
Derivation of human differential photoreceptor-like cells from the iris by defined combinations of CRX, RX and NEUROD.
GeneRIF
Umezawa et al., Japan. In Plos One, 2011
Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation.
[Molecular-cellular mechanisms of retina pathology development in people of various age].
Review
D'iakonov et al., In Adv Gerontol, 2011
Mutations in the CRX gene are the cause of progressive states such as cone-rod dystrophy.
Crx broadly modulates the pineal transcriptome.
GeneRIF
Klein et al., Copenhagen, Denmark. In J Neurochem, 2011
Crx broadly modulates the pineal transcriptome and also influences differential night/day gene expression in this tissue
No interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.
GeneRIF
Craigie et al., Bethesda, United States. In Plos One, 2010
Data show no interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.
Review
Impact
Forrest et al., Bethesda, United States. In Nat Rev Neurosci, 2010
Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate.
Leber congenital amaurosis: genes, proteins and disease mechanisms.
Review
Cremers et al., Nijmegen, Netherlands. In Prog Retin Eye Res, 2008
The LCA genes encode proteins with a wide variety of retinal functions, such as photoreceptor morphogenesis (CRB1, CRX), phototransduction (AIPL1, GUCY2D), vitamin A cycling (LRAT, RDH12, RPE65), guanine synthesis (IMPDH1), and outer segment phagocytosis (MERTK).
Regulation of photoreceptor gene expression by Crx-associated transcription factor network.
Review
Chen et al., Saint Louis, United States. In Brain Res, 2008
This regulation is mediated by a network of photoreceptor transcription factors centered on Crx, an Otx-like homeodomain transcription factor.
Genotype-phenotype correlation in a German family with a novel complex CRX mutation extending the open reading frame.
Review
GeneRIF
Lorenz et al., Regensburg, Germany. In Ophthalmology, 2007
description of a 2-generation family with a novel mutation in CRX; the resulting phenotype is that of cone-rod dystrophy with variable age at onset and progression
Otx5 regulates genes that show circadian expression in the zebrafish pineal complex.
Impact
Liang et al., Baltimore, United States. In Nat Genet, 2002
The gene cone rod homeobox (crx), a member of the orthodenticle homeobox (otx) family, is thought to regulate pineal circadian activity.
Nrl is required for rod photoreceptor development.
Impact
Swaroop et al., Ann Arbor, United States. In Nat Genet, 2001
It acts synergistically with Crx to regulate rhodopsin transcription.
Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis.
Impact
Daiger et al., Houston, United States. In Nat Genet, 2000
4) and CRX (ref.
Retinopathy and attenuated circadian entrainment in Crx-deficient mice.
Impact
Cepko et al., Boston, United States. In Nat Genet, 1999
Crx, an Otx-like homeobox gene, is expressed specifically in the photoreceptors of the retina and the pinealocytes of the pineal gland.
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