Experimental TLR4 inhibition improves intestinal microcirculation in endotoxemic rats.
Halifax, Canada. In Microvasc Res, 24 Jul 2015
MATERIALS AND METHODS: The intestinal microcirculation was studied by intravital microscopy in four groups of Lewis rats (n=10 per group): healthy controls (CON group), endotoxemic animals (15mg/kg lipopolysaccharide, LPS group), endotoxemic animals treated with a TLR4 antagonist (1mg/kg CRX-526, LPS+CRX group), and controls treated with CRX-526 (CRX group).
Gene regulation: it matters who you hang out with.
Baltimore, United States. In Neuron, 08 May 2015
Andzelm, Cherry et al. (2015) demonstrate that myocyte enhancer factor 2D (MEF2D) binds and activates retina-specific regulatory regions by cooperative interaction with the tissue-specific transcription factor CRX.