gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 10 Apr 2015.

Cone-rod homeobox

CRX
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ROD, Rhodopsin, CAN, LCa, Otx2
Papers on CRX
Gene Regulation: It Matters Who You Hang Out With.
New
Zack et al., Baltimore, United States. In Neuron, 08 May 2015
(2015) demonstrate that myocyte enhancer factor 2D (MEF2D) binds and activates retina-specific regulatory regions by cooperative interaction with the tissue-specific transcription factor CRX.
MEF2D Drives Photoreceptor Development through a Genome-wide Competition for Tissue-Specific Enhancers.
New
Greenberg et al., Boston, United States. In Neuron, 18 Apr 2015
MEF2D achieves specificity by cooperating with a retina-specific factor CRX, which recruits MEF2D away from canonical MEF2 binding sites and redirects it to retina-specific enhancers that lack the consensus MEF2-binding sequence.
Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells.
New
Furukawa et al., Suita, Japan. In Genes Cells, 11 Apr 2015
We also observed that Mef2d synergistically activates the cone arrestin (Arr3) promoter with Crx, suggesting that functional cooperation between Mef2d and Crx is important for photoreceptor cell gene regulation.
Differential Dimerization of Variants Linked to Enhanced S-Cone Sensitivity Syndrome (ESCS) Located in the NR2E3 Ligand-Binding Domain.
New
Escher et al., Sion, Switzerland. In Hum Mutat, 23 Mar 2015
NR2E3 LBD variants did not affect interaction with CRX, but with NRL and rev-erbα/NR1D1.
Gene expression changes during retinal development and rod specification.
New
Farrar et al., Dublin, Ireland. In Mol Vis, Dec 2014
Many of these genes' promoters contain binding sites for the key photoreceptor transcription factors Crx and Nr2e3; moreover, the genomic clustering of differentially regulated genes appears to be non-random.
Induction of ectopic retina-like tissue by transgenic expression of neurogenin.
New
Wang et al., Birmingham, United States. In Plos One, Dec 2014
The ectopic retina-like tissue contained cells positive for photoreceptor proteins Crx, recoverin, red opsin, and rhodopsin, and cells positive for proteins that label other types of retinal neurons, including AP2α and Pax6 for amacrine cells, Otx2 for bipolar cells, and Brn3A for ganglion cells.
FAM161A, a novel centrosomal-ciliary protein implicated in autosomal recessive retinitis pigmentosa.
Review
Stöhr et al., Regensburg, Germany. In Adv Exp Med Biol, 2013
Homozygous and compound heterozygous null mutations in the CRX-regulated FAM161A gene of unknown function were identified as a cause for autosomal recessive RP (RP28) in patients from India, Germany, Israel, the Palestinian territories, and the USA.
Homeobox genes and melatonin synthesis: regulatory roles of the cone-rod homeobox transcription factor in the rodent pineal gland.
Review
Rath et al., Copenhagen, Denmark. In Biomed Res Int, 2013
Among these, the cone-rod homeobox (CRX) transcription factor is believed to control pineal-specific Aanat expression.
Immunohistochemical expression of CRX in extracranial malignant small round cell tumors.
GeneRIF
Perez-Atayde et al., Boston, United States. In Am J Surg Pathol, 2012
These findings suggest that CRX is a useful marker to discriminate metastatic retinoblastoma from other, more common, malignant small round cell tumors of childhood
Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysis.
GeneRIF
Swaroop et al., Bethesda, United States. In Plos Genet, 2011
Our results show that NRL and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis-regulatory module
Derivation of human differential photoreceptor-like cells from the iris by defined combinations of CRX, RX and NEUROD.
GeneRIF
Umezawa et al., Japan. In Plos One, 2011
Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation.
[Molecular-cellular mechanisms of retina pathology development in people of various age].
Review
D'iakonov et al., In Adv Gerontol, 2011
Mutations in the CRX gene are the cause of progressive states such as cone-rod dystrophy.
Crx broadly modulates the pineal transcriptome.
GeneRIF
Klein et al., Copenhagen, Denmark. In J Neurochem, 2011
Crx broadly modulates the pineal transcriptome and also influences differential night/day gene expression in this tissue
No interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.
GeneRIF
Craigie et al., Bethesda, United States. In Plos One, 2010
Data show no interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.
Review
Impact
Forrest et al., Bethesda, United States. In Nat Rev Neurosci, 2010
Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate.
Leber congenital amaurosis: genes, proteins and disease mechanisms.
Review
Cremers et al., Nijmegen, Netherlands. In Prog Retin Eye Res, 2008
The LCA genes encode proteins with a wide variety of retinal functions, such as photoreceptor morphogenesis (CRB1, CRX), phototransduction (AIPL1, GUCY2D), vitamin A cycling (LRAT, RDH12, RPE65), guanine synthesis (IMPDH1), and outer segment phagocytosis (MERTK).
Otx5 regulates genes that show circadian expression in the zebrafish pineal complex.
Impact
Liang et al., Baltimore, United States. In Nat Genet, 2002
The gene cone rod homeobox (crx), a member of the orthodenticle homeobox (otx) family, is thought to regulate pineal circadian activity.
Nrl is required for rod photoreceptor development.
Impact
Swaroop et al., Ann Arbor, United States. In Nat Genet, 2001
It acts synergistically with Crx to regulate rhodopsin transcription.
Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis.
Impact
Daiger et al., Houston, United States. In Nat Genet, 2000
4) and CRX (ref.
Retinopathy and attenuated circadian entrainment in Crx-deficient mice.
Impact
Cepko et al., Boston, United States. In Nat Genet, 1999
Crx, an Otx-like homeobox gene, is expressed specifically in the photoreceptors of the retina and the pinealocytes of the pineal gland.
share on facebooktweetadd +1mail to friends