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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

Cone-rod homeobox

CRX
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ROD, Rhodopsin, CAN, LCa, Otx2
Papers on CRX
Using Zinc Finger Nuclease Technology to Generate CRX-Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation.
New
Lako et al., Newcastle upon Tyne, United Kingdom. In Stem Cells, Dec 2015
UNASSIGNED: The purpose of this study was to generate human embryonic stem cell (hESC) lines harboring the green fluorescent protein (GFP) reporter at the endogenous loci of the Cone-Rod Homeobox (CRX) gene, a key transcription factor in retinal development.
Decellularized retinal matrix: Natural platforms for human retinal progenitor cell culture.
New
Carrier et al., Boston, United States. In Acta Biomater, Dec 2015
RT-PCR analysis revealed hRPC expression of rhodopsin, rod outer membrane, neural retina-specific leucine zipper neural and cone-rod homeobox gene on decell-retina films, indicating photoreceptor development.
PEG modified liposomes containing CRX-601 adjuvant in combination with methylglycol chitosan enhance the murine sublingual immune response to influenza vaccination.
New
Burkhart et al., Hamilton, United States. In J Control Release, Dec 2015
Herein we demonstrate a robust immune response against influenza antigens co-delivered sublingually with engineered liposomes carrying the synthetic Toll-like receptor-4 agonist, CRX-601.
Comprehensive interactome of Otx2 in the adult mouse neural retina.
New
Lamonerie et al., Nice, France. In Genesis, Nov 2015
In this tissue, Otx2 is thought to have overlapping function with its paralog Crx.
OTX2 is a therapeutic target for retinoblastoma and may function as a common factor between C-MYC, CRX, and phosphorylated RB pathways.
New
Adamson et al., Durham, United States. In Int J Oncol, Nov 2015
Loss of OTX2 expression also resulted in decreased expression of C-MYC and CRX, genes previously implicated in retinoblastoma tumorigenesis.
A novel CRX mutation by whole-exome sequencing in an autosomal dominant cone-rod dystrophy pedigree.
Zhang et al., Ningbo, China. In Int J Ophthalmol, 2014
RESULTS: The results of both WES and Sanger sequencing revealed a novel nonsense mutation c.C766T (p.Q256X) within exon 5 of CRX gene which was pathogenic for adCORD in this family.
Mechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathies.
Review
Chen et al., Saint Louis, United States. In Dev Dyn, 2014
BACKGROUND: The homeodomain transcription factor CRX is a crucial regulator of mammalian photoreceptor gene expression.
Homeobox genes and melatonin synthesis: regulatory roles of the cone-rod homeobox transcription factor in the rodent pineal gland.
Review
Rath et al., Copenhagen, Denmark. In Biomed Res Int, 2013
Among these, the cone-rod homeobox (CRX) transcription factor is believed to control pineal-specific Aanat expression.
FAM161A, a novel centrosomal-ciliary protein implicated in autosomal recessive retinitis pigmentosa.
Review
Stöhr et al., Regensburg, Germany. In Adv Exp Med Biol, 2013
Homozygous and compound heterozygous null mutations in the CRX-regulated FAM161A gene of unknown function were identified as a cause for autosomal recessive RP (RP28) in patients from India, Germany, Israel, the Palestinian territories, and the USA.
Immunohistochemical expression of CRX in extracranial malignant small round cell tumors.
GeneRIF
Perez-Atayde et al., Boston, United States. In Am J Surg Pathol, 2012
These findings suggest that CRX is a useful marker to discriminate metastatic retinoblastoma from other, more common, malignant small round cell tumors of childhood
Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysis.
GeneRIF
Swaroop et al., Bethesda, United States. In Plos Genet, 2011
Our results show that NRL and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis-regulatory module
Derivation of human differential photoreceptor-like cells from the iris by defined combinations of CRX, RX and NEUROD.
GeneRIF
Umezawa et al., Japan. In Plos One, 2011
Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation.
[Molecular-cellular mechanisms of retina pathology development in people of various age].
Review
D'iakonov et al., In Adv Gerontol, 2011
Mutations in the CRX gene are the cause of progressive states such as cone-rod dystrophy.
Crx broadly modulates the pineal transcriptome.
GeneRIF
Klein et al., Copenhagen, Denmark. In J Neurochem, 2011
Crx broadly modulates the pineal transcriptome and also influences differential night/day gene expression in this tissue
No interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.
GeneRIF
Craigie et al., Bethesda, United States. In Plos One, 2010
Data show no interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.
Review
Impact
Forrest et al., Bethesda, United States. In Nat Rev Neurosci, 2010
Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate.
Otx5 regulates genes that show circadian expression in the zebrafish pineal complex.
Impact
Liang et al., Baltimore, United States. In Nat Genet, 2002
The gene cone rod homeobox (crx), a member of the orthodenticle homeobox (otx) family, is thought to regulate pineal circadian activity.
Nrl is required for rod photoreceptor development.
Impact
Swaroop et al., Ann Arbor, United States. In Nat Genet, 2001
It acts synergistically with Crx to regulate rhodopsin transcription.
Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis.
Impact
Daiger et al., Houston, United States. In Nat Genet, 2000
4) and CRX (ref.
Retinopathy and attenuated circadian entrainment in Crx-deficient mice.
Impact
Cepko et al., Boston, United States. In Nat Genet, 1999
Crx, an Otx-like homeobox gene, is expressed specifically in the photoreceptors of the retina and the pinealocytes of the pineal gland.
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