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Prostaglandin D2 receptor 2

CRTH2, DP2
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: TH2, Transcription Factor DP1, ACID, PGD2, CAN
Papers on CRTH2
Dietary Patterns High in Red Meat, Potato, Gravy, and Butter Are Associated with Poor Cognitive Functioning but Not with Rate of Cognitive Decline in Very Old Adults.
New
Jagger et al., Newcastle upon Tyne, United Kingdom. In J Nutr, Feb 2016
When compared with participants in DP1 (high red meat) and DP3 (high butter), participants in DP2 (low meat) had higher SMMSE scores at baseline (P < 0.001) and follow-ups, and better initial attention (P < 0.05).
Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation.
Review
New
McKee et al., Denver, United States. In J Immunol, Feb 2016
Recent structural analysis of a Be-specific TCR interacting with a Be-loaded HLA-DP2-peptide complex revealed that Be is coordinated by amino acid residues derived from the HLA-DP2 β-chain and peptide and showed that the TCR does not directly interact with the Be(2+) cation.
Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection.
New
Dingemanse et al., Allschwil, Switzerland. In Clin Pharmacokinet, Jan 2016
BACKGROUND AND OBJECTIVE: The chemoattractant receptor-homologous molecule expressed on T helper-2 cells (CRTH2) is a G-protein-coupled receptor for prostaglandin D2 (PGD2), a key mediator in inflammatory disorders.
Ikaros, Helios, and Aiolos protein levels increase in human thymocytes after β selection.
New
Yankee et al., Kansas City, United States. In Immunol Res, Jan 2016
In each group of patients, CD3(-) ISP and DP thymocytes were subdivided into ISP1, ISP2, DP1, DP2, DP3, DP4, and DP5 developmental stages according to their expression of CD28, CD44, CD1a, CD7, CD45RO, and CD38.
Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung.
New
Brusselle et al., Gent, Belgium. In Plos One, Dec 2015
IL12Rβ2, CRTH2 and CD117 respectively) and key transcription factors (i.e.
Morphology of a fossil elephant calf (Archidiskodon, Elephantidae) from the Oldowan Muhkai IIa site.
New
Ozherelyev et al., Moscow, Russia. In Dokl Biol Sci, Nov 2015
A skull fragment and lower jaw with functioning teeth of the DP2/DP3 generation are preserved.
Recent advance in investigation of gene polymorphisms in Japanese patients with aspirin-exacerbated respiratory disease.
Review
Mochizuki et al., Annaka, Japan. In Allergol Immunopathol (madr), 2015
Here, we described on our recent genetic investigations on B2ADR, IL-13, IL-17A, CYP2C19, TBXA2R, CRTH2 and HSP70.
Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.
Impact
Kappler et al., Denver, United States. In Cell, 2014
Individuals carrying the MHCII allele, HLA-DP2, are at risk for chronic beryllium disease (CBD), a debilitating inflammatory lung condition caused by the reaction of CD4 T cells to inhaled beryllium.
Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs.
Review
Norman, Norman, United States. In Expert Opin Investig Drugs, 2014
INTRODUCTION: The identification of PGD2 as the cognate ligand for the DP2 (formerly CRTH2) receptor and the apparent role of that receptor in allergic disease has led to considerable interest in the development of DP2 receptor antagonists for the treatment of asthma.
An overview of the role of innate lymphoid cells in gut infections and inflammation.
Review
Monteleone et al., Roma, Italy. In Mediators Inflamm, 2013
Specifically, ILCs1 express the transcription factor T-bet and secrete T helper type-1- (Th1-) related cytokines, ILCs2 are dependent on the transcription factor RORα and express Gata-3 and the chemokine receptor homologous molecule (CRTH2) and produce Th2-related cytokines, and ILCs3 express the transcription factor RORγt and synthesize interleukin- (IL-) 17, IL-22, and, under specific stimuli, interferon-γ.
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.
Impact
Spits et al., Amsterdam, Netherlands. In Immunity, 2012
CRTH2(+) ILC2s were enriched in nasal polyps of patients with chronic rhinosinusitis, a typical type 2-mediated disease.
CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis.
GeneRIF
Betsuyaku et al., Tokyo, Japan. In J Immunol, 2012
Genetic ablation of CRTH2 improves impaired neutrophil migration and survival during severe sepsis
Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates.
GeneRIF
Danielsson et al., Uppsala, Sweden. In J Proteomics, 2012
DGCR2, GPR44 and SerpinB10, found in beta cells, were negative in all other cell types within pancreas and exposed epitopes at the cell surface
Thromboxane A2 receptor +795T>C and chemoattractant receptor-homologous molecule expressed on Th2 cells -466T>C gene polymorphisms in patients with aspirin-exacerbated respiratory disease.
GeneRIF
Kurosawa et al., Japan. In Mol Med Report, 2012
The frequencies of the TT genotype of CRTH2 -466T>C were higher than those of the CC/CT genotype in aspirin-exacerbated respiratory disease patients compared to aspirin-tolerant asthma patients
PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.
GeneRIF
Kostenis et al., Bonn, Germany. In Plos One, 2011
identify PGH(1) as an important lipid intermediate and novel CRTH2 agonist which may trigger CRTH2 activation in vivo in the absence of functional prostaglandin D synthase.
Roles of CRTH2+ CD4+ T cells in immunoglobulin G4-related lacrimal gland enlargement.
GeneRIF
Nakajima et al., Chiba, Japan. In Int Arch Allergy Immunol, 2011
we show that CRTH2+ CD4+ T cells may be involved in the enhanced Th2 cell-mediated immunity in IgG4-related lacrimal gland enlargement.
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.
Impact
GeneRIF
Spits et al., Amsterdam, Netherlands. In Nat Immunol, 2011
expression defines IL-25- and IL-33-responsive type 2 innate lymphoid cells
International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress.
Review
Impact
Narumiya et al., Irvine, United States. In Pharmacol Rev, 2011
The DP(2) receptor, also termed CRTH2, has little structural resemblance to DP(1) and other receptors described in the original prostanoid receptor classification.
Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases.
Review
Impact
Armer et al., Abingdon, United Kingdom. In Nat Rev Drug Discov, 2007
Pharmacological studies using the recently discovered DP(1) and CRTH2 antagonists combined with genetic analysis support the view that these receptors have a pivotal role in mediating aspects of allergic diseases that are resistant to current therapy.
Cytoprotective Role of Prostaglandin D2 DP1 Receptor against Neuronal Injury Following Acute Excitotoxicity and Cerebral Ischemia
Review
Shafique Ahmad et al., Boca Raton, United States. In Unknown Journal, 0001
These PGs exert their actions through specific high-affinity G protein-coupled receptors named DP1-DP2 (PGD2 receptor 1-PGD2 receptor 2), EP1-EP4 (PGE2 receptor 1-4), FP (PGF2α receptor), IP (PGI2 receptor or prostacyclin receptor), and TP (thromboxane receptor) receptors, respectively.
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