Characterization of the influence of mediator complex in HIV-1 transcription.
Badalona, Spain. In J Biol Chem, 2014
Knockdown of 9 out of 28 human MED proteins significantly impaired viral replication without affecting cell viability, including MED6, MED7, MED11, MED14, MED21, MED26, MED27, MED28, and MED30.
Regulation of MYC expression and differential JQ1 sensitivity in cancer cells.
Boston, United States. In Plos One, 2013
Molecularly, these differences appear due to requirements of Brd4, the most active version of the Positive Transcription Elongation Factor B (P-TEFb) within the Super Elongation Complex (SEC), and transcription factors such as Gdown1, and MED26 and also other unknown cell specific factors.