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Mediator complex subunit 27

Crsp34, Med27
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: POLYMERASE, TRAP100, PCNA, ROD, MED4
Papers on Crsp34
Distribution Analyzer, a methodology for identifying and clustering outlier conditions from single-cell distributions, and its application to a Nanog reporter RNAi screen.
Lemischka et al., New York City, United States. In Bmc Bioinformatics, 2014
Similarly, siRNA targeting Med14 or Med27 leads to a narrower Nanog reporter fluorescence distribution.
Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex.
Hermand et al., Namur, Belgium. In Cell Rep, 2012
Cdk11 is broadly distributed onto chromatin and phosphorylates the Med27 and Med4 Mediator subunits on conserved residues.
Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex.
Bourbon, Toulouse, France. In Nucleic Acids Res, 2008
Saccharomyces cerevisiae Med2, Med3/Pgd1 and Med5/Nut1 subunits are apparent homologs of metazoan Med29/Intersex, Med27/Crsp34 and Med24/Trap100, respectively, and these and other 30 identified human MED subunits have detectable counterparts in the amoeba Dictyostelium discoideum, indicating that none is specific to metazoans.
Differential roles of transcriptional mediator complex subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 during zebrafish retinal development.
GeneRIF
Driever et al., Freiburg, Germany. In Genetics, 2006
Ubiquitous expression of crsp34 mRNA may suggest a universal requirement for Crsp34 in transcriptional initiation.
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