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Exportin 1

CRM1, exportin 1
The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, importin, RAN, ACID
Papers using CRM1 antibodies
TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus.
Luban Jeremy, In PLoS Pathogens, 1997
... Murine and human CRM1 cDNAs were obtained from Open Biosystems (Thermo Scientific) and cloned into pcDNA3.1 ...
Papers on CRM1
HIV-1 Nef-associated factor 1 enhances viral production by interacting with CRM1 to promote nuclear export of unspliced HIV-1 gag mRNA.
Wang et al., China. In J Biol Chem, Feb 2016
The cellular protein Naf1 (HIV-1 Nef-associated factor 1) is a CRM1-dependent nucleo-cytoplasmic shuttling protein, and has been identified to regulate multiple receptor-mediated signal pathways in inflammation.
The GTPase RAN regulates multiple steps of the centrosome life cycle.
Lavia, Roma, Italy. In Chromosome Res, Feb 2016
RAN cooperates with the protein nuclear export vector exportin 1/CRM1 to recruit scaffolding proteins containing nuclear export sequences that play roles in the structural organization of centrosomes.
RanBP3 Regulates Melanoma Cell Proliferation via Selective Control of Nuclear Export.
Wagner et al., Vienna, Austria. In J Invest Dermatol, Jan 2016
Chromosome region maintenance 1-mediated nucleocytoplasmic transport has been shown as a potential anticancer target in various malignancies.
Activated ErbB3 translocates to the nucleus via clathrin-independent endocytosis which is associated with proliferating cells.
Hengstler et al., Germany. In J Biol Chem, Jan 2016
Our results also demonstrate that ErbB3s nuclear localization is transient as it is exported out of the nucleus by the nuclear receptor protein crm-1.
Dynamic Distribution and Interaction of the Arabidopsis SRSF1 Subfamily Splicing Factors.
Motte et al., Liège, Belgium. In Plant Physiol, Jan 2016
Furthermore, the RNA-binding motif mutants are defective for their export through the XPO1 (CRM1/Exportin-1) receptor pathway, but retain nucleocytoplasmic mobility.
Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy.
Matsuda et al., Niigata, Japan. In World J Gastroenterol, Dec 2015
Chromosome region maintenance 1 (CRM1) is a major nuclear export receptor involved in transport of tumor suppressors from nucleus to cytoplasm.
Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.
Andreeff et al., Houston, United States. In Pharmacol Ther, Sep 2015
The nuclear exporter chromosome region maintenance 1 (CRM1) protein is the only protein in the karyopherin-β protein family that contributes to the trafficking of numerous proteins and RNAs from the nucleus.
Structural Basis of Targeting the Exportin CRM1 in Cancer.
Ficner et al., Göttingen, Germany. In Cells, 2014
The exportin CRM1 (Chromosome region maintenance 1) exports a plethora of different protein cargoes and ribonucleoprotein complexes.
Multiple Export Mechanisms for mRNAs.
Borden et al., Montréal, Canada. In Cells, 2014
We describe multiple mechanisms of mRNA export including NXF1 and CRM1 mediated pathways.
Nuclear Export as a Novel Therapeutic Target: The CRM1 Connection.
Gao et al., Lubbock, United States. In Curr Cancer Drug Targets, 2014
The ubiquitous exportin Chromosome Region Maintenance 1 (CRM1) is involved in the transport of many proteins and RNA molecules from nucleus to cytoplasm.
Mammalian 5'-capped microRNA precursors that generate a single microRNA.
Steitz et al., New Haven, United States. In Cell, 2014
The m(7)G-capped pre-miRNAs are exported via the PHAX-exportin 1 pathway.
The Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc.
Shen et al., Beijing, China. In Development, 2012
Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc
A CRM1-dependent nuclear export signal controls nucleocytoplasmic translocation of HSCARG, which regulates NF-κB activity.
Zheng et al., Beijing, China. In Traffic, 2012
CRM1 dependent nucleocytoplasmic translocation of HSCARG plays an important role in fine-tuning NF-kappaB signaling
CRM1 plays a nuclear role in transporting snoRNPs to nucleoli in higher eukaryotes.
Bertrand et al., Montpellier, France. In Nucleus, 2012
CRM1, as an export receptor, can also control the composition of nucleoplasmic complexes
Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism.
Igarashi et al., Sendai, Japan. In Febs Lett, 2012
Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism.
Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis.
Oren et al., Israel. In Mol Cell, 2012
Exportin 1 (XPO1) is regulated positively by c-Myc and negatively by p53.
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.
Campo et al., Oviedo, Spain. In Nature, 2011
Further analysis of these mutations in 363 patients with CLL identified four genes that are recurrently mutated: notch 1 (NOTCH1), exportin 1 (XPO1), myeloid differentiation primary response gene 88 (MYD88) and kelch-like 6 (KLHL6).
Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP.
Ficner et al., Göttingen, Germany. In Science, 2009
study presents the crystal structure of the SPN1.CRM1.RanGTP export complex at 2.5 angstrom resolution (where SPN1 is snurportin1 and RanGTP is guanosine 5' triphosphate-bound Ran
Structural basis for leucine-rich nuclear export signal recognition by CRM1.
Chook et al., Dallas, United States. In Nature, 2009
2.9 A crystal structure of CRM1 bound to snurportin 1
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.
Nakayama et al., Fukuoka, Japan. In Nat Cell Biol, 2004
The nuclear export of p27(Kip1) by CRM1 seems to be necessary for KPC-mediated proteolysis.
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