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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cyclin-dependent kinase 12

CRK7, CrkRS, CDK12, cyclin-dependent kinase 12
human homolog may play a role in regulation of transcription and splicing [RGD, Feb 2006] (from NCBI)
Papers on CRK7
The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.
Peterlin et al., San Francisco, United States. In Genes Dev, 2011
through regulation of expression of DNA damage response genes, CycK/Cdk12 protects cells from genomic instability
CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.
Greenleaf et al., Durham, United States. In Genes Dev, 2010
Data show that siRNA knockdown of hCDK12 in HeLa cells results in alterations in the CTD phosphorylation state.
CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.
Ashworth et al., London, United Kingdom. In Carcinogenesis, 2009
CRK7 modifies MAP kinases regulation and resistance to estrogen signaling inhibitors in breast cancers.
Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation.
Fann et al., Taipei, Taiwan. In Mol Cell Biol, 2006
CDK12 and cyclin L1/L2 are cyclin-dependent kinase and cyclin partners and regulate alternative splicing.
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