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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cyclin-dependent kinase 12

CRK7, CrkRS, CDK12, cyclin-dependent kinase 12
human homolog may play a role in regulation of transcription and splicing [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: PCNA, POLYMERASE, TAK, CDC2, Iris
Papers on CRK7
Ovarian cancers harboring inactivating mutations in CDK12 display a distinct genomic instability pattern characterized by large tandem duplications.
Stern et al., In Cancer Res, Feb 2016
UNASSIGNED: CDK12 is a recurrently mutated gene in serous ovarian carcinoma, whose downregulation is associated with impaired expression of DNA damage repair genes and subsequent hypersensitivity to DNA damaging agents and PARP1/2 inhibitors.
Identification and Characterization of the Cyclin-Dependent Kinases Gene Family in Silkworm, Bombyx mori.
Zhang et al., Beijing, China. In Dna Cell Biol, Jan 2016
Gene structure analysis suggested that CDK12 and CDC2L1 owned two and three isoforms, respectively.
Cdk12 is essential for embryonic development and the maintenance of genomic stability.
Fann et al., Taipei, Taiwan. In Cell Death Differ, Jan 2016
Studies from cultured cells have demonstrated that cyclin-dependent kinase 12 (Cdk12) is a multifunctional protein that maintains genomic stability and the pluripotency of embryonic stem cells.
RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.
Roeder et al., New York City, United States. In Science, Jan 2016
We found that Pol II-associated factor 1 (PAF1) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb) directly regulates the initial recruitment of PAF1 complex (PAF1C) to genes, and that the subsequent recruitment of CDK12 is dependent on PAF1C.
Heterochromatin remodeling by CDK12 contributes to learning in Drosophila.
Sun et al., Beijing, China. In Proc Natl Acad Sci U S A, Dec 2015
Here, we report that cyclin-dependent kinase 12 (CDK12), a transcription elongation-associated RNA polymerase II (RNAPII) kinase, antagonizes heterochromatin enrichment in Drosophila chromosomes.
Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold.
Cramer et al., G├Âttingen, Germany. In Proteins, Oct 2015
CTDK-I contains the cyclin-dependent kinase Ctk1 (homologous to human CDK9/CDK12), the cyclin Ctk2 (human cyclin K), and the yeast-specific subunit Ctk3, which is required for CTDK-I stability and activity.
Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas.
Greenleaf et al., United States. In Biochim Biophys Acta, Sep 2015
The RNA Polymerase II C-terminal domain (CTD) kinase CDK12 has been implicated as a tumor suppressor and regulator of DNA damage response genes.
Lentivirus-mediated RNA Interference Targeting LAPTM4B Inhibits Human Ovarian Cancer Cell Invasion In Vitro.
Fu et al., Harbin, China. In Chem Biol Drug Des, Sep 2015
Furthermore, LAPTM4B depletion resulted in a significant decrease in proliferating cell nuclear antigen, vascular endothelial growth factor, MMP2, MMP9, and CDK12 expression.
Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.
Barboric et al., Helsinki, Finland. In Nucleic Acids Res, Apr 2015
The Cdk12/CycK complex promotes expression of a subset of RNA polymerase II genes, including those of the DNA damage response.
Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.
Shilatifard et al., Kansas City, United States. In Mol Cell Biol, Mar 2015
Cyclin-dependent kinase 9 (CDK9) and CDK12 have each been demonstrated to phosphorylate the RNA polymerase II C-terminal domain (CTD) at serine 2 of the heptad repeat, both in vitro and in vivo.
Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.
Bullock et al., Vancouver, Canada. In Sci Rep, 2014
Cyclin-dependent kinase 12 (CDK12) promotes transcriptional elongation by phosphorylation of the RNA polymerase II C-terminal domain (CTD).
LAPTM4B down regulation inhibits the proliferation, invasion and angiogenesis of HeLa cells in vitro.
Lou et al., Harbin, China. In Cell Physiol Biochem, 2014
In vitro, HeLa cells with down regulated LAPTM4B also exhibited decreased migration and invasion activity as well as significantly reduced CDK12, HIF-1╬▒, MMP-2, MMP-9 and VEGF expression.
[Function of CDK12 in Tumor initiation and progression and its clinical consequences].
Kohoutek et al., In Klin Onkol, 2013
Recently, CDK12 was identified as a key factor orchestrating transcription of genes, such as BRCA1, ATM, ATR, FANCI and FANCD2, which are involved in the DNA-damage response pathway.
Absolute quantification of somatic DNA alterations in human cancer.
Getz et al., Cambridge, United States. In Nat Biotechnol, 2012
This analysis identified both pervasive subclonal somatic point-mutations and a small subset of predominantly clonal and homozygous mutations, which were overrepresented in the tumor suppressor genes TP53 and NF1 and in a candidate tumor suppressor gene CDK12.
The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.
Peterlin et al., San Francisco, United States. In Genes Dev, 2011
through regulation of expression of DNA damage response genes, CycK/Cdk12 protects cells from genomic instability
Integrated genomic analyses of ovarian carcinoma.
Cancer Genome Atlas Research Network, In Nature, 2011
Here we report that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1, BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes.
CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.
Greenleaf et al., Durham, United States. In Genes Dev, 2010
Data show that siRNA knockdown of hCDK12 in HeLa cells results in alterations in the CTD phosphorylation state.
CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.
Ashworth et al., London, United Kingdom. In Carcinogenesis, 2009
CRK7 modifies MAP kinases regulation and resistance to estrogen signaling inhibitors in breast cancers.
Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation.
Fann et al., Taipei, Taiwan. In Mol Cell Biol, 2006
CDK12 and cyclin L1/L2 are cyclin-dependent kinase and cyclin partners and regulate alternative splicing.
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