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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

V-crk sarcoma virus CT10 oncogene homolog

Top mentioned proteins: Src, CAN, Actin, CD43, V1a
Papers using Crk antibodies
Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components
Plattner Rina et al., In Oncogene, 2007
... Melanoma tissue microarrays were incubated with normal rabbit serum (NRS) or phospho-Crk/CrkL antibody (Y2221/Y207), hematoxylin stained, and visualized with Dako Red ...
Early molecular events in the assembly of the focal adhesion-stress fiber complex during fibroblast spreading
Waterman Clare M. et al., In The Journal of Cell Biology, 2003
... anti–pY31-paxillin, rabbit anti–pY397-FAK, mouse anti-FAK, and rabbit anti–pY273-paxillin (Invitrogen); mouse anti-Hic5, mouse antipaxillin, and mouse anti-Crk (BD); rabbit antipaxillin (Santa Cruz Biotechnology, Inc.); mouse antitalin clone ...
The EphA4 receptor regulates dendritic spine remodeling by affecting β1-integrin signaling pathways
Pasquale Elena B. et al., In The Journal of Cell Biology, 1999
... Monoclonal antibody to FAK, Cas, Crk, and β1 integrin were purchased from BD Biosciences.
Internalization of Chlamydia by dendritic cells and stimulation of Chlamydia-specific T cells.
Van Nhieu Guy Tran, In PLoS Pathogens, 1997
... anti-WAVE2 (Santa Cruz), mouse anti-gfp (Roche), mouse and rabbit anti-HA (Roche), mouse anti-gfp (Roche), mouse anti-Crk (BD Transduction), rabbit anti-CrkII (Tyr221) (Cell Signaling), rabbit anti-goat IgG HRP ...
Papers on Crk
Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway.
Kalodimos et al., Minneapolis, United States. In Nat Chem Biol, Feb 2016
Here we demonstrate that CypA binds the CrkII adaptor protein and prevents it from switching to the inhibited state.
Role of CrkII Signaling in RANKL-Induced Osteoclast Differentiation and Function.
Kim et al., Kwangju, South Korea. In J Immunol, Jan 2016
Phosphorylation of p130 Crk-associated substrate (p130Cas) by osteoclastogenic cytokines in preosteoclasts increased the interaction between p130Cas and CrkII, which is known to be involved in Rac1 activation.
Mice null for NEDD9 (HEF1) display extensive hippocampal dendritic spine loss and cognitive impairment.
Clagett-Dame et al., Madison, United States. In Brain Res, Jan 2016
UNASSIGNED: NEDD9 (neural precursor cell expressed, developmentally down-regulated 9) is a member of the CAS (Crk-associated substrate) family of scaffolding proteins that regulate cell adhesion and migration.
Temperature Dependence of CN and SCN IR Absorptions Facilitates Their Interpretation and Use as Probes of Proteins.
Romesberg et al., Los Angeles, United States. In Anal Chem, Dec 2015
We then show that the same linear dependence is observed with p-cyano phenylalanine, cyanylated cysteine, or cyanylated homocysteine incorporated at different positions within the N-terminal Src homology 3 domain of the murine adapter protein Crk-II.
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members.
Golemis et al., Philadelphia, United States. In Gene, Nov 2015
The CAS (Crk-associated substrate) adaptor protein family consists of four members: CASS1/BCAR1/p130Cas, CASS2/NEDD9/HEF1/Cas-L, CASS3/EFS/Sin and CASS4/HEPL.
Structure and function of Gab2 and its role in cancer (Review).
Luo et al., Zunyi, China. In Mol Med Report, Sep 2015
Gab2 protein lacks intrinsic catalytic activity; however, when phosphorylated by protein‑tyrosine kinases (PTKs), Gab2 recruits several Src homology‑2 (SH2) domain‑containing proteins, including the SH2‑containing protein tyrosine phosphatase 2 (SHP2), the p85 subunit of phosphoinositide‑3 kinase (PI3K), phospholipase C‑γ (PLCγ)1, Crk, and GC‑GAP.
Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation.
Glass et al., Cambridge, United States. In Mol Cell Biol, 2014
Crk and CrkL are noncatalytic adaptor proteins necessary for the formation of neuromuscular synapses which function downstream of muscle-specific kinase (MuSK), a receptor tyrosine kinase expressed in skeletal muscle, and the MuSK binding protein Dok-7.
The Role of Crk Adaptor Proteins in T-Cell Adhesion and Migration.
Isakov et al., Beersheba, Israel. In Front Immunol, 2014
This article addresses mechanisms that regulate CrkII conformation and function, in general, and emphasizes the role of Crk proteins in receptor-coupled signaling pathways that control T-lymphocyte adhesion and migration to inflammatory sites.
The adaptor protein Crk in immune response.
Liu, Houston, United States. In Immunol Cell Biol, 2014
The adaptor proteins Crk (CT10 (chicken tumor virus number 10) regulator of kinase), including CrkI, CrkII and Crk-like, are important signal molecules that regulate a variety of cellular processes.
Contribution of Crk adaptor proteins to host cell and bacteria interactions.
Hardwidge et al., Madrid, Spain. In Biomed Res Int, 2013
The Crk adaptor family of proteins comprises the alternatively spliced CrkI and CrkII isoforms, as well as the paralog Crk-like (CrkL) protein, which is encoded by a different gene.
Controlling natural killer cell responses: integration of signals for activation and inhibition.
Rajagopalan et al., Rockville, United States. In Annu Rev Immunol, 2012
MHC-I-specific inhibitory receptors both block activation signals and trigger signals to phosphorylate and inactivate the small adaptor Crk.
The adaptor protein Crk controls activation and inhibition of natural killer cells.
Long et al., Rockville, United States. In Immunity, 2012
Natural killer (NK) cell inhibitory receptors recruit tyrosine phosphatases to prevent activation, induce phosphorylation and dissociation of the small adaptor Crk from cytoskeleton scaffold complexes, and maintain NK cells in a state of responsiveness to subsequent activation events.
The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.
Oakes et al., San Francisco, United States. In Nat Cell Biol, 2012
We discovered that the principal component of the purified pro-apoptotic activity is the proto-oncoprotein CRK (CT10-regulated kinase), an adaptor protein with no known catalytic activity.
Integrin signalling adaptors: not only figurants in the cancer story.
Defilippi et al., Torino, Italy. In Nat Rev Cancer, 2010
We specifically underline the contribution of p130 Crk-associated substrate (p130CAS; also known as BCAR1), neural precursor cell expressed, developmentally down-regulated 9 (NEDD9; also known as HEF1), CRK and the integrin-linked kinase (ILK)-pinch-parvin (IPP) complex to cancer, along with the more recently identified p140 Cas-associated protein (p140CAP; also known as SRCIN1).
An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression.
Cheresh et al., San Diego, United States. In Nat Med, 2009
These effects required recruitment of c-Src to the beta(3) integrin cytoplasmic tail, leading to c-Src activation, Crk-associated substrate (CAS) phosphorylation and tumor cell survival that, unexpectedly, was independent of cell adhesion or focal adhesion kinase (FAK) activation.
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