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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Aug 2015.

Teratocarcinoma-derived growth factor 1

Cripto, Cripto-1, TDGF1, C-R
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: NODAL, Epidermal Growth Factor, CAN, SFRP1, TGF-beta
Papers on Cripto
The gga-let-7 family post-transcriptionally regulates TGFBR1 and LIN28B during the differentiation process in early chick development.
New
Byun et al., Suwŏn, South Korea. In Mol Reprod Dev, 22 Sep 2015
Our data further indicate that TGFBR1 and LIN28B maintain pluripotency by regulating POUV, NANOG, and CRIPTO.
Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.
New
Niakan et al., Farmington, United States. In Development, 20 Sep 2015
For example, we identify several genes exclusively expressed in the human pluripotent epiblast including the transcription factor KLF17. Key components of the TGF-β signaling pathway including NODAL, GDF3, TGFBR1/ALK5, LEFTY1, SMAD2, SMAD4 and TDGF1 are also enriched in the human epiblast.
Serum cripto-1 as a clinical marker for lung cancer.
New
Yu et al., Nanjing, China. In Int J Biol Markers, 11 Jul 2015
BACKGROUND: Cripto-1 (CR-1) plays an important role in angiogenesis related to tumor growth, in concert with vascular endothelial growth factor (VEGF), and enhanced expression of CR-1 has been reported in lung cancer tissue.
Cripto-1 as a novel therapeutic target for triple negative breast cancer.
New
Salomon et al., Frederick, United States. In Oncotarget, Jun 2015
Cripto-1, an embryonic stem cell marker, was present in spindle-like areas and its promoter showed activity in primary tumors.
Morphological and Gene Expression Changes in Cattle Embryos from Hatched Blastocyst to Early Gastrulation Stages after Transfer of In Vitro Produced Embryos.
New
Pfeffer et al., Hamilton, New Zealand. In Plos One, Dec 2014
A detailed morphological staging system for cattle embryos at stages following blastocyst hatching and preceding gastrulation is presented here together with spatiotemporal mapping of gene expression for BMP4, BRACHYURY, CERBERUS1 (CER1), CRIPTO, EOMESODERMIN, FURIN and NODAL.
Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity.
New
Luo et al., Århus, Denmark. In Stem Cell Res Ther, Dec 2014
The iPSC-MSCs and the tri-lineage differentiated cells (osteoblasts, chondrocytes, adipocytes) all lack expression of "stemness" genes: OCT4, SOX2, GDF3, CRIPTO, UTF1, DPPA4, DNMT3B, LIN28a, and SAL4.
Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.
GeneRIF
Tofanelli et al., Pisa, Italy. In Gene, 2013
R. norvegicus DHRS2 and DHRS4 genes are syntenic outparalogs that originated from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade. R. norvegicus genes are orthologs of human DHRS2 and DHRS4 genes respectively.
Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors.
Review
Koopman et al., Brisbane, Australia. In Int J Dev Biol, 2012
Recently the Nodal/Cripto signaling pathway, known to control pluripotency and differentiation in embryonic stem (ES) cells, was implicated in regulating normal male fetal germ cell pluripotency.
Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1α in the hypoxic bone marrow niche.
Review
Karlsson et al., Lund, Sweden. In Ann N Y Acad Sci, 2012
Cripto has been known as an embryonic stem (ES)- or tumor-related soluble/cell membrane protein.
Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis.
Review
GeneRIF
Vale et al., Los Angeles, United States. In Febs Lett, 2012
Cripto/GRP78 modulates the TGF-beta pathway in development and oncogenesis [review]
Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.
Review
GeneRIF
Bianco et al., Frederick, United States. In Am J Pathol, 2012
Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.
An evolving web of signaling networks regulated by Cripto-1.
Review
Bianco et al., Bethesda, United States. In Growth Factors, 2012
Over the past few decades, our understanding of the embryonic gene Cripto-1 has considerably advanced through biochemical, cell biology, and animal studies.
Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78.
Impact
GeneRIF
Karlsson et al., Lund, Sweden. In Cell Stem Cell, 2011
These data suggest that Cripto/GRP78 signaling is an important pathway that regulates hematopoietic stem cell quiescence.
Expression and functional role of CRIPTO-1 in cutaneous melanoma.
GeneRIF
Normanno et al., Napoli, Italy. In Br J Cancer, 2011
High CRIPTO-1 is associated with cutaneous melanoma.
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.
Impact
Zhang et al., United Kingdom. In Nat Biotechnol, 2007
They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3.
Extraembryonic proteases regulate Nodal signalling during gastrulation.
Impact
Constam et al., China. In Nat Cell Biol, 2002
This process is triggered by Nodal, a protein related to transforming growth factor-beta (TFG-beta) that is expressed in the epiblast and visceral endoderm, and its co-receptor Cripto, which is induced downstream of Nodal.
Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo.
Impact
Shen et al., United States. In Nature, 1998
Here we show that correct localization of both head- and trunk-organizing centres requires Cripto, a putative signalling molecule that is a member of the EGF-CFC gene family.
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