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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Teratocarcinoma-derived growth factor 1

Cripto, Cripto-1, TDGF1, C-R
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: NODAL, Epidermal Growth Factor, CAN, SFRP1, TGF-beta
Papers on Cripto
Microarray Analyses Reveal Marked Differences in Growth Factor and Receptor Expression Between 8-Cell Human Embryos and Pluripotent Stem Cells.
New
Kiessling et al., Athens, Greece. In Stem Cells Dev, 15 Feb 2016
Forty-four gene elements were underdetected on the 8C arrays, including 11 at least 80-fold under the pluripotent cells: two cytokines (IFITM1, TNFRSF8), five TGFBs (BMP7, LEFTY1, LEFTY2, TDGF1, TDGF3), two FGFs (FGF2, FGF receptor 1), plus ING5, and WNT6.
The gga-let-7 family post-transcriptionally regulates TGFBR1 and LIN28B during the differentiation process in early chick development.
New
Byun et al., South Korea. In Mol Reprod Dev, 31 Dec 2015
Our data further indicate that TGFBR1 and LIN28B maintain pluripotency by regulating POUV, NANOG, and CRIPTO.
Serum Cripto-1 is a novel biomarker for non-small cell lung cancer diagnosis and prognosis.
New
Wang et al., Nanjing, China. In Clin Respir J, 25 Dec 2015
INTRODUCTION: Cripto-1 (CR-1) is highly expressed in several different types of human tumors.
Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors.
New
Looijenga et al., Brisbane, Australia. In Mol Oncol, 18 Dec 2015
The Nodal co-receptor Cripto is expressed transiently during normal germ cell development and is ectopically expressed in non-seminomas that arise from germ cell neoplasia in situ, suggesting that its aberrant expression may underlie germ cell dysregulation and hence germ cell cancer.
Cripto-1 Ablation Disrupts Alveolar Development in the Mouse Mammary Gland through a Progesterone Receptor-Mediated Pathway.
New
Raafat et al., Bethesda, United States. In Am J Pathol, Nov 2015
Cripto-1, a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic family, is critical for early embryonic development.
Elevated expression of Cripto-1 correlates with poor prognosis in hepatocellular carcinoma.
New
Guo et al., Guangzhou, China. In Oncotarget, Nov 2015
Cripto-1 could promote tumorigenesis in a wide range of carcinomas, yet little is known in hepatocellular carcinoma (HCC).
Cripto-1 modulates macrophage cytokine secretion and phagocytic activity via NF-κB signaling.
New
Song et al., Changchun, China. In Immunol Res, Nov 2015
UNASSIGNED: Cripto-1 is an oncogenic protein belonging to the epidermal growth factor-Cripto-1/FRL-1/Cryptic family.
Dynamic regulation of the cancer stem cell compartment by Cripto-1 in colorectal cancer.
New
Zeuner et al., Roma, Italy. In Cell Death Differ, Oct 2015
We found that the embryonic protein Cripto-1 (CR1) was expressed by normal stem cells at the bottom of colonic crypts and by cancer stem cells (CSCs) in colorectal tumor tissues.
Cripto-1: an extracellular protein - connecting the sequestered biological dots.
Cuttitta et al., Frederick, United States. In Connect Tissue Res, 2014
Cripto-1 (CR-1) is a multifunctional embryonic protein that is re-expressed during inflammation, wound repair, and malignant transformation.
New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding.
Sandomenico et al., Napoli, Italy. In Int J Mol Sci, 2014
Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1.
Cripto-1 Promotes the Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma Cells.
Fu et al., Chongqing, China. In Evid Based Complement Alternat Med, 2014
Several lines of evidence have shown that Cripto-1 plays an important oncogenic role during tumorigenesis by promoting EMT.
Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.
GeneRIF
Tofanelli et al., Pisa, Italy. In Gene, 2013
R. norvegicus DHRS2 and DHRS4 genes are syntenic outparalogs that originated from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade. R. norvegicus genes are orthologs of human DHRS2 and DHRS4 genes respectively.
Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis.
GeneRIF
Vale et al., Los Angeles, United States. In Febs Lett, 2012
Cripto/GRP78 modulates the TGF-beta pathway in development and oncogenesis [review]
Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.
GeneRIF
Bianco et al., Frederick, United States. In Am J Pathol, 2012
Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.
Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78.
Impact
GeneRIF
Karlsson et al., Lund, Sweden. In Cell Stem Cell, 2011
These data suggest that Cripto/GRP78 signaling is an important pathway that regulates hematopoietic stem cell quiescence.
Expression and functional role of CRIPTO-1 in cutaneous melanoma.
GeneRIF
Normanno et al., Napoli, Italy. In Br J Cancer, 2011
High CRIPTO-1 is associated with cutaneous melanoma.
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.
Impact
Zhang et al., United Kingdom. In Nat Biotechnol, 2007
They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3.
Extraembryonic proteases regulate Nodal signalling during gastrulation.
Impact
Constam et al., China. In Nat Cell Biol, 2002
This process is triggered by Nodal, a protein related to transforming growth factor-beta (TFG-beta) that is expressed in the epiblast and visceral endoderm, and its co-receptor Cripto, which is induced downstream of Nodal.
Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo.
Impact
Shen et al., United States. In Nature, 1998
Here we show that correct localization of both head- and trunk-organizing centres requires Cripto, a putative signalling molecule that is a member of the EGF-CFC gene family.
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