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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 10 Nov 2014.

Teratocarcinoma-derived growth factor 1

Cripto, Cripto-1, TDGF1, C-R
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: NODAL, Epidermal Growth Factor, CAN, SFRP1, TGF-beta
Papers on Cripto
Cripto-1 expression and its prognostic value in human bladder cancer patients.
New
Hu et al., Wuxi, China. In Tumour Biol, 19 Nov 2014
UNLABELLED: Cripto-1 is an important embryonic gene that involved in self-renewal and maintenance of pluripotency of stem cells.
Expression of Nodal, Cripto, SMAD3, Phosphorylated SMAD3, and SMAD4 in the Proliferative Endometrium of Women With Endometriosis.
New
Reis et al., Belo Horizonte, Brazil. In Reprod Sci, 16 Oct 2014
The effects of Nodal are modulated by the coreceptor Cripto and mediated by SMAD proteins.
Elevated expression of Cripto-1 correlates with poor prognosis in non-small cell lung cancer.
New
Yu et al., Nanjing, China. In Tumour Biol, Sep 2014
Human Cripto-1 (CR-1) plays an important oncogenic role during tumorigenesis and is overexpressed in a wide range of carcinomas, yet little is known about CR-1 in non-small cell lung cancer (NSCLC).
The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition.
Review
New
Salomon et al., Frederick, United States. In Semin Cancer Biol, Sep 2014
UNLABELLED: Cripto-1 (CR-1)/Teratocarcinoma-derived growth factor1 (TDGF-1) is a cell surface glycosylphosphatidylinositol (GPI)-linked glycoprotein that can function either in cis (autocrine) or in trans (paracrine).
Cripto haploinsufficiency affects in vivo colon tumor development.
New
Liguori et al., Napoli, Italy. In Int J Oncol, Jul 2014
Cripto (also called Teratocarcinoma-derived growth factor), the original member of the vertebrate EGF-CFC family, plays a key role in all of these pathways and is deeply involved in early embryo development and cancer progression.
CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo.
New
Gray et al., Los Angeles, United States. In Stem Cell Reports, May 2014
Here, we identify CRIPTO and its cell-surface receptor GRP78 as regulators of stem cell behavior in isolated fetal and adult mammary epithelial cells.
Tumorigenic factor CRIPTO-1 is immunolocalized in extravillous cytotrophoblast in placenta creta.
New
Bevilacqua et al., São Paulo, Brazil. In Biomed Res Int, Dec 2013
CRIPTO-(CR)1 is a protein associated with tumorigenesis and metastasis.
Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.
GeneRIF
Tofanelli et al., Pisa, Italy. In Gene, 2013
R. norvegicus DHRS2 and DHRS4 genes are syntenic outparalogs that originated from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade. R. norvegicus genes are orthologs of human DHRS2 and DHRS4 genes respectively.
Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors.
Review
Koopman et al., Brisbane, Australia. In Int J Dev Biol, 2012
Recently the Nodal/Cripto signaling pathway, known to control pluripotency and differentiation in embryonic stem (ES) cells, was implicated in regulating normal male fetal germ cell pluripotency.
Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1α in the hypoxic bone marrow niche.
Review
Karlsson et al., Lund, Sweden. In Ann N Y Acad Sci, 2012
Cripto has been known as an embryonic stem (ES)- or tumor-related soluble/cell membrane protein.
Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis.
Review
GeneRIF
Vale et al., Los Angeles, United States. In Febs Lett, 2012
Cripto/GRP78 modulates the TGF-beta pathway in development and oncogenesis [review]
Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.
Review
GeneRIF
Bianco et al., Frederick, United States. In Am J Pathol, 2012
Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.
Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78.
Impact
GeneRIF
Karlsson et al., Lund, Sweden. In Cell Stem Cell, 2011
These data suggest that Cripto/GRP78 signaling is an important pathway that regulates hematopoietic stem cell quiescence.
Expression and functional role of CRIPTO-1 in cutaneous melanoma.
GeneRIF
Normanno et al., Napoli, Italy. In Br J Cancer, 2011
High CRIPTO-1 is associated with cutaneous melanoma.
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.
Impact
Zhang et al., United Kingdom. In Nat Biotechnol, 2007
They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3.
Extraembryonic proteases regulate Nodal signalling during gastrulation.
Impact
Constam et al., China. In Nat Cell Biol, 2002
This process is triggered by Nodal, a protein related to transforming growth factor-beta (TFG-beta) that is expressed in the epiblast and visceral endoderm, and its co-receptor Cripto, which is induced downstream of Nodal.
Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo.
Impact
Shen et al., United States. In Nature, 1998
Here we show that correct localization of both head- and trunk-organizing centres requires Cripto, a putative signalling molecule that is a member of the EGF-CFC gene family.
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