Common Expression of Stemness Molecular Markers and Early Cardiac Transcription Factors In Wharton's Jelly-Derived Mesenchymal Stem Cells and hESCs.
In Cell Transplant, 04 Mar 2013
Our results demonstrated for the first time that WJ-MSCs had significant expression of undifferentiated human embryonic stem cell core markers, such as SOX2, NANOG, LIN28, SSEA1, SSEA2, SSEA3, SSEA4, KLF4, c-MYC, CRIPTO, and REX1 with a relatively lower level of expression than in hESCs.
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.
United Kingdom. In Nat Biotechnol, 2007
They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3.