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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 18 Mar 2014.

Teratocarcinoma-derived growth factor 1

Cripto, Cripto-1, TDGF1, C-R
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: NODAL, Epidermal Growth Factor, CAN, SFRP1, TGF-beta
Papers on Cripto
NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells.
New
Fasano et al., United States. In Cell Rep, 27 Mar 2014
A time-course transcriptome analysis and functional assays show that NPTX1 acts in part by binding the Nodal receptor cofactor TDGF1, reducing both Nodal and BMP signaling.
Cripto-1 expression in glioblastoma multiforme.
New
Duroux et al., Aalborg, Denmark. In Brain Pathol, 13 Mar 2014
Cripto-1 (CR-1) has a key regulatory role in embryogenesis, while in adult tissue re-expression of CR-1 has been correlated to malignant progression in solid cancers of non-neuronal origin.
MiR-15a-16 represses Cripto and inhibits NSCLC cell progression.
New
Liu et al., Tianjin, China. In Mol Cell Biochem, 06 Mar 2014
In this study, downregulation of miR-15a-16 in nonsmall cell lung cancer (NSCLC) was found to be inversely correlated with Cripto.
Designer nodal/BMP2 chimeras mimic nodal signaling, promote chondrogenesis, and reveal a BMP2-like structure.
New
Choe et al., In J Biol Chem, 17 Feb 2014
Three chimeras, named NB250, NB260, and NB264, show Nodal-like signaling properties including dependence on the co-receptor Cripto and activation of the Smad2 pathway.
Clinicopathological and biological significance of cripto overexpression in human colon cancer.
New
Zhao et al., Taiyuan, China. In World J Gastroenterol, Jan 2014
AIM: To assess the clinicopathological and biological significance of cripto in human colorectal cancer.
Age-Dependent Association between Protein Expression of the Embryonic Stem Cell Marker Cripto-1 and Survival of Glioblastoma Patients.
New
Hendrix et al., Bergen, Norway. In Transl Oncol, Jan 2014
Nodal signaling is regulated by the Cripto-1 co-receptor and another TGF-β member, Lefty.
Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.
GeneRIF
Tofanelli et al., Pisa, Italy. In Gene, 2013
R. norvegicus DHRS2 and DHRS4 genes are syntenic outparalogs that originated from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade. R. norvegicus genes are orthologs of human DHRS2 and DHRS4 genes respectively.
Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors.
Review
Koopman et al., Brisbane, Australia. In Int J Dev Biol, 2012
Recently the Nodal/Cripto signaling pathway, known to control pluripotency and differentiation in embryonic stem (ES) cells, was implicated in regulating normal male fetal germ cell pluripotency.
Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1α in the hypoxic bone marrow niche.
Review
Karlsson et al., Lund, Sweden. In Ann N Y Acad Sci, 2012
Cripto has been known as an embryonic stem (ES)- or tumor-related soluble/cell membrane protein.
Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis.
Review
GeneRIF
Vale et al., Los Angeles, United States. In Febs Lett, 2012
Cripto/GRP78 modulates the TGF-beta pathway in development and oncogenesis [review]
Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.
Review
GeneRIF
Bianco et al., Frederick, United States. In Am J Pathol, 2012
Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.
An evolving web of signaling networks regulated by Cripto-1.
Review
Bianco et al., Bethesda, United States. In Growth Factors, 2012
Over the past few decades, our understanding of the embryonic gene Cripto-1 has considerably advanced through biochemical, cell biology, and animal studies.
Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78.
Impact
GeneRIF
Karlsson et al., Lund, Sweden. In Cell Stem Cell, 2011
These data suggest that Cripto/GRP78 signaling is an important pathway that regulates hematopoietic stem cell quiescence.
Expression and functional role of CRIPTO-1 in cutaneous melanoma.
GeneRIF
Normanno et al., Napoli, Italy. In Br J Cancer, 2011
High CRIPTO-1 is associated with cutaneous melanoma.
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.
Impact
Zhang et al., United Kingdom. In Nat Biotechnol, 2007
They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3.
Extraembryonic proteases regulate Nodal signalling during gastrulation.
Impact
Constam et al., China. In Nat Cell Biol, 2002
This process is triggered by Nodal, a protein related to transforming growth factor-beta (TFG-beta) that is expressed in the epiblast and visceral endoderm, and its co-receptor Cripto, which is induced downstream of Nodal.
Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo.
Impact
Shen et al., United States. In Nature, 1998
Here we show that correct localization of both head- and trunk-organizing centres requires Cripto, a putative signalling molecule that is a member of the EGF-CFC gene family.
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