GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Teratocarcinoma-derived growth factor 1
Cripto, Cripto-1, TDGF1, C-R
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from
NCBI)
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Papers on
Cripto
NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway.
New
Shanghai, China. In Int J Biochem Cell Biol, 06 Apr 2013
NANOG activates NODAL and CRIPTO-1 to promote SMAD3 phosphorylation and SNAIL expression.
All-trans retinoic acid and basic fibroblast growth factor synergistically direct pluripotent human embryonic stem cells to extraembryonic lineages.
New
Köln, Germany. In Stem Cell Res, 31 Mar 2013
The stemness markers POU5F1, NANOG and TDGF1 were markedly downregulated, whereas an upregulation of the ExE markers KRT7, CGA, DDAH2 and IGFBP3 was observed.
Suppression of Lefty expression in induced pluripotent cancer cells.
New
Chiba, Japan. In Faseb J, 13 Mar 2013
Expression of Cripto, another important factor in Nodal-Lefty signaling, was not increased after adding TGF-β.
Common Expression of Stemness Molecular Markers and Early Cardiac Transcription Factors In Wharton's Jelly-Derived Mesenchymal Stem Cells and hESCs.
New
In Cell Transplant, 04 Mar 2013
Our results demonstrated for the first time that WJ-MSCs had significant expression of undifferentiated human embryonic stem cell core markers, such as SOX2, NANOG, LIN28, SSEA1, SSEA2, SSEA3, SSEA4, KLF4, c-MYC, CRIPTO, and REX1 with a relatively lower level of expression than in hESCs.
Expression of Activin Receptor-like Kinase 7 in Adipose Tissues.
New
Sagamihara, Japan. In Biochem Genet, Jan 2013
Nodal transmits signals via Alk7 in cooperation with its coreceptor, Cripto.
Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly.
New
Aurora, United States. In Biol Open, Oct 2012
Disruption of the GPI-anchored protein Cripto (mouse) and TDGF1 (human ortholog) have been shown to result in holoprosencephaly, leading to our hypothesis that Cripto is the key GPI anchored protein whose altered function results in an HPE-like phenotype.
Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1α in the hypoxic bone marrow niche.
Review
New
Lund, Sweden. In Ann N Y Acad Sci, Aug 2012
Cripto has been known as an embryonic stem (ES)- or tumor-related soluble/cell membrane protein.
Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis.
Review
New
Los Angeles, United States. In Febs Lett, Aug 2012
Cripto is a small, GPI-anchored signaling protein that regulates cellular survival, proliferation, differentiation and migration during normal developmental processes and tumorigenesis.
Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.
Review
New
Frederick, United States. In Am J Pathol, Jun 2012
Cripto-1, a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family, together with the transforming growth factor (TGF)-β family ligand Nodal, regulates both cell movement and EMT during embryonic development.
An evolving web of signaling networks regulated by Cripto-1.
Review
New
Bethesda, United States. In Growth Factors, Feb 2012
Over the past few decades, our understanding of the embryonic gene Cripto-1 has considerably advanced through biochemical, cell biology, and animal studies.
The role of Cripto-1 in the tumorigenesis and progression of oral squamous cell carcinoma.
GeneRIF
Seoul, South Korea. In Oral Oncol, 2011
Cripto-1 plays a role in the malignant transformation of oral mucosa and is involved in the tumorigenesis and progression of oral squamous cell carcinoma by promoting the growth and migration of malignant cells.
Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78.
Impact
Lund, Sweden. In Cell Stem Cell, 2011
Here we demonstrate that Cripto and its receptor GRP78 are important regulators of HSCs in the niche.
Expression and functional role of CRIPTO-1 in cutaneous melanoma.
GeneRIF
Napoli, Italy. In Br J Cancer, 2011
High CRIPTO-1 is associated with cutaneous melanoma.
Regulation of extra-embryonic endoderm stem cell differentiation by Nodal and Cripto signaling.
GeneRIF
New York City, United States. In Development, 2011
Distinct pathways for Nodal and Cripto in the differentiation of visceral endoderm and anterior visceral endoderm from extra-embryonic endoderm stem cells.
Cross-ecosystem differences in stability and the principle of energy flux.
Review
Guelph, Canada. In Ecol Lett, 2011
That is, we show that increased energy flux, relative to the consumer loss rate, makes C-R interactions top heavy (i.e., greater C:R biomass ratio) and less stable.
Altered expression of activin, cripto, and follistatin in the endometrium of women with endometrioma.
GeneRIF
Siena, Italy. In Fertil Steril, 2011
Disturbed expression of endometrial activin A, cripto , and follistatin suggests a dysfunction of the activin pathway in endometriosis/endometrioma.
Intercellular transfer regulation of the paracrine activity of GPI-anchored Cripto-1 as a Nodal co-receptor.
GeneRIF
Bethesda, United States. In Biochem Biophys Res Commun, 2011
expression of CR-1 may alter the physiochemical properties of the plasma membrane resulting in an enhancement of intercellular transfer of cellular signaling components which may account for the paracrine activity of CR-1.
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.
Impact
United Kingdom. In Nat Biotechnol, 2007
They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3.
Extraembryonic proteases regulate Nodal signalling during gastrulation.
Impact
China. In Nat Cell Biol, 2002
This process is triggered by Nodal, a protein related to transforming growth factor-beta (TFG-beta) that is expressed in the epiblast and visceral endoderm, and its co-receptor Cripto, which is induced downstream of Nodal.
Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo.
Impact
United States. In Nature, 1998
Here we show that correct localization of both head- and trunk-organizing centres requires Cripto, a putative signalling molecule that is a member of the EGF-CFC gene family.
