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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Nov 2015.

Teratocarcinoma-derived growth factor 1

Cripto, Cripto-1, TDGF1, C-R
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: NODAL, Epidermal Growth Factor, CAN, SFRP1, TGF-beta
Papers on Cripto
Cripto-1 Ablation Disrupts Alveolar Development in the Mouse Mammary Gland through a Progesterone Receptor-Mediated Pathway.
Raafat et al., Bethesda, United States. In Am J Pathol, 30 Nov 2015
Cripto-1, a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic family, is critical for early embryonic development.
Microarray Analyses Reveal Marked Differences in Growth Factor and Receptor Expression Between 8-Cell Human Embryos and Pluripotent Stem Cells.
Kiessling et al., Athens, Greece. In Stem Cells Dev, 22 Nov 2015
Forty-four gene elements were under-detected on the 8C arrays, including 11 at least 80-fold under the pluripotent cells: two cytokines (IFITM1, TNFRSF8), five TGFBs (BMP7, LEFTY1, LEFTY2, TDGF1, TDGF3), two FGFs (FGF2, FGFR1) plus ING5 and WNT6.
Cripto-1 modulates macrophage cytokine secretion and phagocytic activity via NF-κB signaling.
Song et al., Changchun, China. In Immunol Res, 17 Nov 2015
UNASSIGNED: Cripto-1 is an oncogenic protein belonging to the epidermal growth factor-Cripto-1/FRL-1/Cryptic family.
Elevated expression of Cripto-1 correlates with poor prognosis in hepatocellular carcinoma.
Guo et al., Guangzhou, China. In Oncotarget, 05 Oct 2015
UNASSIGNED: Cripto-1 could promote tumorigenesis in a wide range of carcinomas, yet little is known in hepatocellular carcinoma (HCC).
New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding.
Sandomenico et al., Napoli, Italy. In Int J Mol Sci, Dec 2014
Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1.
Cripto-1 Promotes the Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma Cells.
Fu et al., Chongqing, China. In Evid Based Complement Alternat Med, Dec 2014
Several lines of evidence have shown that Cripto-1 plays an important oncogenic role during tumorigenesis by promoting EMT.
Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.
Tofanelli et al., Pisa, Italy. In Gene, 2013
R. norvegicus DHRS2 and DHRS4 genes are syntenic outparalogs that originated from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade. R. norvegicus genes are orthologs of human DHRS2 and DHRS4 genes respectively.
Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors.
Koopman et al., Brisbane, Australia. In Int J Dev Biol, 2012
Recently the Nodal/Cripto signaling pathway, known to control pluripotency and differentiation in embryonic stem (ES) cells, was implicated in regulating normal male fetal germ cell pluripotency.
Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1α in the hypoxic bone marrow niche.
Karlsson et al., Lund, Sweden. In Ann N Y Acad Sci, 2012
Cripto has been known as an embryonic stem (ES)- or tumor-related soluble/cell membrane protein.
Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis.
Vale et al., Los Angeles, United States. In Febs Lett, 2012
Cripto/GRP78 modulates the TGF-beta pathway in development and oncogenesis [review]
Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.
Bianco et al., Frederick, United States. In Am J Pathol, 2012
Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.
An evolving web of signaling networks regulated by Cripto-1.
Bianco et al., Bethesda, United States. In Growth Factors, 2012
Over the past few decades, our understanding of the embryonic gene Cripto-1 has considerably advanced through biochemical, cell biology, and animal studies.
Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78.
Karlsson et al., Lund, Sweden. In Cell Stem Cell, 2011
These data suggest that Cripto/GRP78 signaling is an important pathway that regulates hematopoietic stem cell quiescence.
Expression and functional role of CRIPTO-1 in cutaneous melanoma.
Normanno et al., Napoli, Italy. In Br J Cancer, 2011
High CRIPTO-1 is associated with cutaneous melanoma.
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.
Zhang et al., United Kingdom. In Nat Biotechnol, 2007
They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3.
Extraembryonic proteases regulate Nodal signalling during gastrulation.
Constam et al., China. In Nat Cell Biol, 2002
This process is triggered by Nodal, a protein related to transforming growth factor-beta (TFG-beta) that is expressed in the epiblast and visceral endoderm, and its co-receptor Cripto, which is induced downstream of Nodal.
Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo.
Shen et al., United States. In Nature, 1998
Here we show that correct localization of both head- and trunk-organizing centres requires Cripto, a putative signalling molecule that is a member of the EGF-CFC gene family.
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