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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cysteine rich transmembrane BMP regulator 1

Crim1, S52, cysteine-rich motor neuron 1
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: V1a, Chordin, TUBE, vascular endothelial growth factor, BMP7
Papers on Crim1
CRIM1, a newfound cancer-related player, regulates the adhesion and migration of lung cancer cells.
New
Tang et al., Chongqing, China. In Growth Factors, Oct 2015
CRIM1 is a member of the bone morphogenetic protein (BMP) antagonists; however, the role of CRIM1 in controlling cancer cell behavior remains unknown.
Inhibition of the proliferation and acceleration of migration of vascular endothelial cells by increased cysteine-rich motor neuron 1.
New
Takahashi et al., Nishinomiya, Japan. In Biochem Biophys Res Commun, Aug 2015
Cysteine-rich motor neuron 1 (CRIM1) is upregulated only in extracellular matrix gels by angiogenic factors such as vascular endothelial growth factor (VEGF).
CRIM1 haploinsufficiency causes defects in eye development in human and mouse.
New
Wollnik et al., Köln, Germany. In Hum Mol Genet, May 2015
We identified a heterozygous deletion predicted to span 22 kb including exons 14-17 of CRIM1 (cysteine-rich transmembrane bone morphogenetic protein (BMP) regulator 1).
Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors.
New
Sohn et al., Seoul, South Korea. In Oncotarget, Apr 2015
We also identified copy number gain and increased mRNA expression of AMACR, CRIM1, SKP2, and CACNA1E.
Genome-wide transcript profiling reveals novel breast cancer-associated intronic sense RNAs.
John et al., Pittsburgh, United States. In Plos One, 2014
Sixteen genomic loci were identified that map to the long introns of five key protein-coding genes, CRIM1, EPAS1, ZEB2, RBMS1, and RFX2.
SOST Inhibits Prostate Cancer Invasion.
Loots et al., Sacramento, United States. In Plos One, 2014
Gene expression analysis of PC3 cells co-cultured with OBs exhibiting varying amounts of Wnt signaling identified CRIM1 as one of the transcripts upregulated under highly invasive conditions.
Induction of cysteine-rich motor neuron 1 mRNA expression in vascular endothelial cells.
Takahashi et al., Nishinomiya, Japan. In Biochem Biophys Res Commun, 2014
Cysteine-rich motor neuron 1 (CRIM1) is expressed in vascular endothelial cells and plays a crucial role in angiogenesis.
Integrative genomics analysis reveals the multilevel dysregulation and oncogenic characteristics of TEAD4 in gastric cancer.
Kim et al., Taejŏn, South Korea. In Carcinogenesis, 2014
This integrative analysis revealed that nine Hippo pathway-related genes, including components [FAT, JUB, LATS2, TEA domain family member 4 (TEAD4) and Yes-associated protein 1 (YAP1)] and targets (CRIM1, CYR61, CTGF and ITGB2), are concurrently hypomethylated at promoter CpG sites and overexpressed in GC tissues.
Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity.
Giannuzzi et al., Norway. In Biomarkers, 2014
METHODS: ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n = 9; II, n = 34; III n = 23), and in 14 controls.
Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.
Lang et al., Cincinnati, United States. In Development, 2014
Using the mouse retina as a model system, we show that cysteine-rich motor neuron 1 (Crim1), a type I transmembrane protein, is highly expressed in angiogenic endothelial cells.
CRIM1, the antagonist of BMPs, is a potential risk factor of cancer.
Review
Tang et al., Chongqing, China. In Curr Cancer Drug Targets, 2013
Cysteine-rich motor neuron1 protein (CRIM1), a novel antagonist of bone morphogenetic proteins (BMPs), is reported to regulate the processing of BMPs preprotein into mature protein and the delivery of BMPs to the cell surface.
Breeding of a cyclic imide-assimilating bacterium, Pseudomonas putida s52, for high efficiency production of pyruvate.
Ogawa et al., Kyoto, Japan. In Biosci Biotechnol Biochem, 2012
A succinimide-assimilating bacterium, Pseudomonas putida s52, was found to be a potent producer of pyruvate from fumarate.
Identification of candidate genes and mutations in QTL regions for chicken growth using bioinformatic analysis of NGS and SNP-chip data.
Marklund et al., Uppsala, Sweden. In Front Genet, 2012
The candidate mutations were identified within the GCG, IGFBP2, GRB14, CRIM1, FGF16, VEGFR-2, ALG11, EDN1, SNX6, and BIRC7 genes.
A genome-wide association study of total serum and mite-specific IgEs in asthma patients.
Shin et al., Seoul, South Korea. In Plos One, 2012
This study found that several new genes might be associated with total IgE in asthmatics, such as CRIM1 (rs848512, P = 1.18×10(-6); rs711254, P = 6.73×10(-6)), ZNF71 (rs10404342, P = 7.60×10(-6)), TLN1 (rs4879926, P = 7.74×10(-6)), and SYNPO2 (rs1472066, P = 8.36×10(-6); rs1038770, P = 8.66×10(-6)).
Genetic variation that predicts platinum sensitivity reveals the role of miR-193b* in chemotherapeutic susceptibility.
Huang et al., Chicago, United States. In Mol Cancer Ther, 2012
Examining the relationships among rs1649942, its gene expression targets, genome-wide miRNA expression, and cellular sensitivity to carboplatin and cisplatin, we identified 2 platinum-associated miRNAs (miR-193b* and miR-320) that inhibit the expression of 5 platinum-associated genes (CRIM1, IFIT2, OAS1, KCNMA1, and GRAMD1B).
Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice.
GeneRIF
Little et al., Australia. In J Pathol, 2012
Crim1 mutations are associated with defects in papillary development and progression to chronic kidney disease later in life.
Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta.
GeneRIF
Little et al., Brisbane, Australia. In Placenta, 2012
Crim1 is required for placental development, and is necessary for the proper differentiation of sinusoidal-trophoblast giant cells and glycogen trophoblast cells.
CRIM1 is expressed at higher levels in drug-resistant than in drug-sensitive myeloid leukemia HL60 cells.
GeneRIF
Strid et al., Örebro, Sweden. In Anticancer Res, 2010
Study demonstrated that CRIM1 is expressed at high levels in resistant leukemia cells, indicating that CRIM1 may play a role in drug-resistance.
Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.
GeneRIF
Little et al., Brisbane, Australia. In J Am Soc Nephrol, 2007
Crim1 regulates the delivery of VEGF-A by the podocytes to the endothelial cells
Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems.
GeneRIF
Little et al., Brisbane, Australia. In Dev Dyn, 2007
Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems.
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