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Calcium regulated heat stable protein 1

CRHSP-24, calcium-regulated heat-stable protein of 24 kDa, Carhsp1
phosphoprotein and calcineurin substrate; involved in calcium-mediated signal transduction [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, Cholecystokinin, fibrillin-1, V1a, PIPPin
Papers on CRHSP-24
Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor α.
GeneRIF
Chen et al., Ann Arbor, United States. In J Biol Chem, 2011
CARHSP1 inhibits hepatic gluconeogenic gene expression via repression of PPARalpha
Structure-functional analyses of CRHSP-24 plasticity and dynamics in oxidative stress response.
GeneRIF
Rao et al., Beijing, China. In J Biol Chem, 2011
CRHSP-24 participates in oxidative stress response via a dynamic and temporal association between stress granules and processing bodies.
RNAi silencing of calcium-regulated heat-stable protein of 24 kDa in Schistosoma japonicum affects parasite growth.
Lin et al., Shanghai, China. In Parasitol Res, 2011
The calcium-regulated heat-stable protein of 24 kDa (CRHSP-24) is a major calcineurin phosphoprotein that functions in multiple signal transduction pathways in cell metabolism.
CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes.
GeneRIF
Brooks et al., United States. In Mol Cell Biol, 2011
Data suggest that CARHSP1 is a TNF-alpha mRNA stability enhancer required for effective TNF-alpha production, demonstrating the importance of both stabilization and destabilization pathways in regulating the TNF-alpha mRNA half-life.
A multistep validation process of biomarkers for preclinical drug development.
Bronson et al., State College, United States. In Pharmacogenomics J, 2010
This particular biomarker panel consisting of 14 genes (C1inh, C1s, Carhsp1, Chi3l1, Gat3, Gbp2, Hspb1, Icam1, Jak3, Kcne2, Lama5, Lgals3, Nppa, Timp1) can be used in diabetic retinopathy pharmacotherapeutic research, and the biomarker development process outlined here is applicable to drug development efforts for other diseases.
Identification of calcineurin regulated phosphorylation sites on CRHSP-24.
GeneRIF
Williams et al., Ann Arbor, United States. In Biochem Biophys Res Commun, 2009
Coordinate phosphorylation of four serines explains the multiple phosphorylated isoforms of CRHSP-24 present in acinar cells.
Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL.
GeneRIF
Cohen et al., Dundee, United Kingdom. In Biochem J, 2005
The purification and identification of CRHSP24 in rat liver extracts, and its role as a substrate for multiple enzymes are reported.
Calcineurin is required for translational control of protein synthesis in rat pancreatic acini.
Williams et al., Ann Arbor, United States. In Am J Physiol Cell Physiol, 2004
The immunosuppressant FK506 dose-dependently inhibited CCK-stimulated protein synthesis over the same concentration range that blocked calcineurin activity, as assessed by dephosphorylation of the calcineurin substrate calcium-regulated heat-stable protein of 24 kDa.
CRHSP-24 phosphorylation is regulated by multiple signaling pathways in pancreatic acinar cells.
GeneRIF
Groblewski et al., München, Germany. In Am J Physiol Gastrointest Liver Physiol, 2003
data indicate that calcium-regulated heat-stable protein-24 is regulated by diverse and physiologically relevant signaling pathways in pancreatic acinar cells
The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production.
Dixon et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2002
Immunoprecipitation of Styx with Crhsp-24, a phosphorylated RNA-binding protein implicated in translational repression of histone mRNAs, provides a strategy for regulating posttranscriptional gene expression.
Purification and characterization of a novel physiological substrate for calcineurin in mammalian cells.
Williams et al., Ann Arbor, United States. In J Biol Chem, 1998
The present study describes the purification and characterization of this novel phosphoprotein, termed CRHSP-24 (calcium-regulated heat-stable protein with a molecular mass of 24 kDa).
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