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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Corticotropin releasing hormone receptor 2

CRF2, CRH-R2, CRFR2
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: CRF1, CRH, V1a, HAD, CAN
Papers on CRF2
Corticotropin-releasing factor augments LPS-induced immune/inflammatory responses in JAWSII cells.
New
Zhang et al., Hangzhou, China. In Immunol Res, Feb 2016
We investigated the expression of CRF and its receptors CRFR1 and CRFR2 in a colonic DC model (JAWSII cells) in a pro-inflammatory and anti-inflammatory milieu.
Urocortins and CRF Receptor Type 2 Variants in the Male Rat Colon: Gene Expression and Regulation by Endotoxin and Anti-inflammatory Effect.
New
Tache et al., Los Angeles, United States. In Am J Physiol Gastrointest Liver Physiol, Feb 2016
UNASSIGNED: Urocortin 1, 2 and 3 (Ucns) and corticotropin releasing factor receptor 2 (CRF2) are prominently expressed in various layers of the upper gut while current knowledge of their expression and regulation in the colonic layers are limited.
Urocortin 2 but not urocortin 3 promotes the synaptic formation in hipppocampal neurons via induction of NGF production by astrocytes.
New
Ni et al., Shanghai, China. In Endocrinology, Jan 2016
We therefore explored the effect of UCN2 and UCN3, the exclusive CRHR2 agonists, on synaptic formation in hippocampus.
Reduced vasopressin receptors activation mediates the anti-depressant effects of fluoxetine and venlafaxine in bulbectomy model of depression.
New
Carlini et al., Córdoba, Argentina. In Psychopharmacology (berl), Jan 2016
RATIONALE: In response to stress, corticotropin releasing hormone (CRH) and vasopressin (AVP) are released from the hypothalamus, activate their receptors (CRHR1, CRHR2 or AVPr1b), and synergistically act to induce adrenocorticotropic hormone (ACTH) release from the anterior pituitary.
Sex differences in the ontogeny of CRF receptors during adolescent development in the dorsal raphe nucleus and ventral tegmental area.
New
Andersen et al., In Synapse, Jan 2016
Tissue was processed and analyzed with qRT-PCR to measure CRF1 and CRF2 receptors.
Regulation of chloroplast development and function by cytokinin.
Review
New
Schmülling et al., Berlin, Germany. In J Exp Bot, Aug 2015
Additional transcription factors linking cytokinin and chloroplast development include CGA1, GNC, HY5, GLK2, and CRF2.
Corticotropin-releasing factor receptor type 1 and type 2 interaction in irritable bowel syndrome.
Review
New
Okumura et al., Asahikawa, Japan. In J Gastroenterol, Aug 2015
CRF in brain and periphery acts through two subtype receptors such as CRF receptor type 1 (CRF1) and type 2 (CRF2), and activating CRF1 exclusively stimulates colonic motor function and induces visceral hypersensitivity.
Corticotropin Releasing Hormone And The Immune/Inflammatory Response
Review
New
Mouslech et al., Madagascar. In Unknown Journal, Aug 2015
The biological effects of CRH are mediated by CRH-Receptor (R)1 and CRH-R2.
New insights into the evolution of vertebrate CRH (corticotropin-releasing hormone) and invertebrate DH44 (diuretic hormone 44) receptors in metazoans.
Review
Larhammar et al., Faro, Portugal. In Gen Comp Endocrinol, 2015
Vertebrates have previously been reported to have two CRHR receptors that were named CRHR1 and CRHR2.
The role of urocortins in the cardiovascular system.
Review
Grodzicki et al., Kraków, Poland. In J Physiol Pharmacol, 2014
The "central" effects of urocortins are mediated mainly by activation of CRH receptor 1 (CRH-R1), and the "peripheral" effects by activation of CRH-R2.
Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive.
Impact
Phillips et al., Seattle, United States. In Nature, 2012
Here we report that corticotropin-releasing factor (CRF), a neuropeptide released in response to acute stressors and other arousing environmental stimuli, acts in the nucleus accumbens of naive mice to increase dopamine release through coactivation of the receptors CRFR1 and CRFR2.
CRH-R1 and CRH-R2 differentially modulate dendritic outgrowth of hippocampal neurons.
GeneRIF
Ni et al., Shanghai, China. In Endocrine, 2012
Data suggest that corticotropin releasing hormone (CRH) regulates dendritic outgrowth in cultured hippocampal neurons/pyramidal cells; signaling via CRH-R1 stimulates dendritic growth; CRH-R2 activation results in inhibition of dendritic growth.
Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population.
GeneRIF
Akiyoshi et al., Ōita, Japan. In Am J Med Genet B Neuropsychiatr Genet, 2012
12 single nucleotide polymorphisms (SNPs) CRHR1 and CRHR2 in major depressive disorder patients (n = 173), panic disorder patients (n = 180), and healthy controls, were investigated.
Susceptibility to PTSD-like behavior is mediated by corticotropin-releasing factor receptor type 2 levels in the bed nucleus of the stria terminalis.
GeneRIF
Chen et al., Israel. In J Neurosci, 2012
data show that CRFR2 mRNA upregulation in the BNST coincides with PTSD-like symptoms Theyfurther show that knockdown of CRFR2 in the posterior medial BNST of adult mice reduces susceptibility to PTSD-like behaviors.
Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation.
GeneRIF
Sawchenko et al., San Diego, United States. In Proc Natl Acad Sci U S A, 2012
Data show that CRFR1 and CRFR2 double-KO mice did not exhibit repeated stress-induced alterations in tau-P or solubility.
Activation of CRHR2 exerts an inhibitory effect on the expression of collapsin response mediator protein 3 in hippocampal neurons.
GeneRIF
Ni et al., Shanghai, China. In Neuropeptides, 2012
CRHR2 activation decrease collapsin response mediator protein 3 expression in hippocampal neurons via a mechanism that is dependent on phospholipase/PKC signaling pathways.
The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology.
Review
Impact
Grammatopoulos et al., Leeds, United Kingdom. In Endocr Rev, 2006
Two types of mammal CRH-R exist, CRH-R1 and CRH-R2, each with unique splicing patterns and remarkably distinct pharmacological properties, but similar signaling properties, probably reflecting their distinct and sometimes contrasting biological functions.
Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.
Impact
Siggins et al., Los Angeles, United States. In Science, 2004
In whole-cell recordings, both CRF and ethanol enhanced gamma-aminobutyric acid-mediated (GABAergic) neurotransmission in CeA neurons from wild-type and CRF2 receptor knockout mice, but not CRF1 receptor knockout mice.
CRF and CRF receptors: role in stress responsivity and other behaviors.
Review
Impact
Vale et al., Philadelphia, United States. In Annu Rev Pharmacol Toxicol, 2003
The mammalian family members include CRF, urocortinI (UcnI), UcnII, and UcnIII, along with two receptors, CRFR1 and CRFR2, and a CRF binding protein.
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Impact
Donnelly et al., Newark, United States. In Nat Immunol, 2003
We identified a distinct receptor complex that is utilized by all three IFN-lambda proteins for signaling and is composed of two subunits, a receptor designated CRF2-12 (also designated as IFN-lambdaR1) and a second subunit, CRF2-4 (also known as IL-10R2).
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