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proteins. Page last changed on 19 Aug 2016.
Corticotropin releasing hormone receptor 2
CRF2, CRH-R2, CRFR2
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011] (from
Tache et al., Los Angeles, United States. In Am J Physiol Gastrointest Liver Physiol, Feb 2016
UNASSIGNED: Urocortin 1, 2 and 3 (Ucns) and corticotropin releasing factor receptor 2 (CRF2) are prominently expressed in various layers of the upper gut while current knowledge of their expression and regulation in the colonic layers are limited.
Carlini et al., Córdoba, Argentina. In Psychopharmacology (berl), Jan 2016
RATIONALE: In response to stress, corticotropin releasing hormone (CRH) and vasopressin (AVP) are released from the hypothalamus, activate their receptors (CRHR1, CRHR2 or AVPr1b), and synergistically act to induce adrenocorticotropic hormone (ACTH) release from the anterior pituitary.
Okumura et al., Asahikawa, Japan. In J Gastroenterol, Aug 2015
CRF in brain and periphery acts through two subtype receptors such as CRF receptor type 1 (CRF1) and type 2 (CRF2), and activating CRF1 exclusively stimulates colonic motor function and induces visceral hypersensitivity.
Phillips et al., Seattle, United States. In Nature, 2012
Here we report that corticotropin-releasing factor (CRF), a neuropeptide released in response to acute stressors and other arousing environmental stimuli, acts in the nucleus accumbens of naive mice to increase dopamine release through coactivation of the receptors CRFR1 and CRFR2.
Data suggest that corticotropin releasing hormone (CRH) regulates dendritic outgrowth in cultured hippocampal neurons/pyramidal cells; signaling via CRH-R1 stimulates dendritic growth; CRH-R2 activation results in inhibition of dendritic growth.
data show that CRFR2 mRNA upregulation in the BNST coincides with PTSD-like symptoms Theyfurther show that knockdown of CRFR2 in the posterior medial BNST of adult mice reduces susceptibility to PTSD-like behaviors.
Grammatopoulos et al., Leeds, United Kingdom. In Endocr Rev, 2006
Two types of mammal CRH-R exist, CRH-R1 and CRH-R2, each with unique splicing patterns and remarkably distinct pharmacological properties, but similar signaling properties, probably reflecting their distinct and sometimes contrasting biological functions.
Siggins et al., Los Angeles, United States. In Science, 2004
In whole-cell recordings, both CRF and ethanol enhanced gamma-aminobutyric acid-mediated (GABAergic) neurotransmission in CeA neurons from wild-type and CRF2 receptor knockout mice, but not CRF1 receptor knockout mice.
Donnelly et al., Newark, United States. In Nat Immunol, 2003
We identified a distinct receptor complex that is utilized by all three IFN-lambda proteins for signaling and is composed of two subunits, a receptor designated CRF2-12 (also designated as IFN-lambdaR1) and a second subunit, CRF2-4 (also known as IL-10R2).