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Corticotropin releasing hormone binding protein

CRF-BP, CRF-binding protein, CRH-BP
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CRH, CRF1, CRF2, CAN, V1a
Papers on CRF-BP
Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides.
New
Stallings et al., Oak Ridge, United States. In Toxicology, Feb 2016
Differential expression of six of these genes (Bdnf, Cort, Crhbp, Nptx2, Npy and Pnoc) was verified in an independent CPF exposure study; immunohistochemistry demonstrated that CRHBP and NPY were elevated in the CA1 region of the hippocampus at 10mg/kg/d CPF.
Genes involved in stress response and alcohol use among high-risk African American youth.
New
Dick et al., Richmond, United States. In Subst Abus, Feb 2016
The aim of this project is to study the interaction between NR3C1 and CRHBP, genes thought to be involved in stress pathways, exposure to stressful life events, and adolescent alcohol use/misuse.
Corticotropin-releasing factor type-2 receptor and corticotropin-releasing factor-binding protein coexist in rat ventral tegmental area nerve terminals originated in the lateral hypothalamic area.
New
Gysling et al., Santiago, Chile. In Eur J Neurosci, Jan 2016
There is significant functional evidence showing that corticotropin-releasing factor type-2 receptor (CRF2 R) and corticotropin-releasing factor-binding protein (CRF-BP) regulate glutamatergic synapses onto ventral tegmental area (VTA) dopaminergic neurons.
CRHBP polymorphisms predict chronic pain development following motor vehicle collision.
New
McLean et al., Chapel Hill, United States. In Pain, Jan 2016
In the present cohort study (n = 855), we evaluated whether genetic variants in several other important HPA axis-related genes, including the glucocorticoid receptor (NR3C1), corticotropin-releasing hormone receptor R1 (CRHR1), and corticotropin-releasing hormone-binding protein (CRHBP), influence risk of chronic MSP over time after MVC.
Reward devaluation and heroin escalation is associated with differential expression of CRF signaling genes.
New
Vrana et al., State College, United States. In Brain Res Bull, Jan 2016
We find that large saccharin suppressors (large heroin takers) demonstrate increased mRNA expression for elements of the CRF signaling pathway (CRF, CRF receptors and CRF binding protein) within the hippocampus, medial prefrontal cortex and the ventral tegmental area.
Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids.
New
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network et al., Colombia. In Am J Perinatol, Oct 2015
RESULTS: CRHBP, CRH, and CRHR1 minor alleles were associated with an increased risk of SGA.
Corticotropin Releasing Hormone And The Immune/Inflammatory Response
Review
New
Mouslech et al., Madagascar. In Unknown Journal, Aug 2015
CRH in plasma is bound to a high-affinity binding protein (CRH-BP) which limits its distribution and activity.
Genetic variants in hypothalamic-pituitary-adrenal axis genes and breast cancer risk in Caucasians and African Americans.
Rebbeck et al., Indianapolis, United States. In Int J Mol Epidemiol Genet, 2014
We evaluated the associations of 49 single nucleotide polymorphisms (SNPs) in five HPA axis genes (NR3C1, NR3C2, CRH, CRHR1, and CRHBP) with the risk of breast cancer in the Women's Insights and Shared Experiences (WISE) Study of Caucasians (346 cases and 442 controls), as well as African Americans (149 cases and 246 controls).
Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior.
Review
Lowry et al., Boulder, United States. In Front Neurosci, 2012
In addition, CRF binding protein (CRFBP) binds both CRF and UCN 1 and can modulate their activities.
Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior.
GeneRIF
Enoch et al., East Orange, United States. In J Psychiatr Res, 2012
CRHBP variation may predispose, independently and additively, to suicidal behavior in individuals who have experienced childhood trauma.
Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin-releasing factor system.
GeneRIF
Ehrenreich et al., G├Âttingen, Germany. In Arch Gen Psychiatry, 2011
interaction of CRHR1 SNP rs110402 and SNP rs3811939 predicts high risk of comorbid alcoholism in schizophrenic patients
Preterm Cervical Ripening in humans.
Review
Dubicke et al., Stockholm, Sweden. In Facts Views Vis Obgyn, 2011
Other important -molecules, such as CRH, CRH-BP, CRH-R1, CRH-R2, HMGB1, TLR2, TLR4, IL-10, IL-12, are localized in the cervical epithelium, also indicating their role in the process of cervical ripening during labour.
[CRF-BP and SLC6A4 gene polymorphisms among restrained eaters].
GeneRIF
Silva et al., Concepci├│n, Chile. In Rev Med Chil, 2011
There was a significant association between the s/s homozygous genotype for the 5-HTTLPR polymorphism of SLC6A4 gene and restrained eating condition (p = 0.033
Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons.
GeneRIF
Gysling et al., Santiago, Chile. In Neuropeptides, 2011
Results show that CRF-BP is efficiently sorted to the regulated secretory pathway in two cellular contexts, suggesting that the extracellular levels of CRF-BP in the central nervous system depends on neuronal activity.
Corticotropin-releasing factor family and its receptors: pro-inflammatory or anti-inflammatory targets in the periphery?
Review
Li et al., Nanjing, China. In Inflamm Res, 2011
The corticotropin-releasing factor (CRF) family of neuropeptides is composed of CRF, urocortin 1 (UCN 1), UCN 2 and UCN 3, which can bind to CRF-binding protein (CRF-BP) and two known receptors, CRFR1 and CRFR2, to perform many pathophysiological functions, including inflammation.
Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes.
GeneRIF
Ray, Los Angeles, United States. In Alcohol Clin Exp Res, 2011
results extend recent preclinical and clinical findings implicating the CRH-BP in stress-related alcoholism and confirm the role of the Asp40 allele of the OPRM1 gene in reward-driven alcohol phenotypes
A ventral tegmental CRF-glutamate-dopamine interaction in addiction.
Review
Morales et al., Baltimore, United States. In Brain Res, 2010
Reinstatement is triggered by some but not all CRF-R2 agonists and some but not all CRF-R1 agonists; the common denominator of the effective agonists is that they bind to the CRF-binding protein (CRF-BP), which appears to be essential for the behavioral and VTA effects of stress and CRF in cocaine-experienced animals.
CRF and CRF receptors: role in stress responsivity and other behaviors.
Review
Impact
Vale et al., Philadelphia, United States. In Annu Rev Pharmacol Toxicol, 2003
The mammalian family members include CRF, urocortinI (UcnI), UcnII, and UcnIII, along with two receptors, CRFR1 and CRFR2, and a CRF binding protein.
Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease.
Impact
De Souza et al., San Diego, United States. In Nature, 1995
The identification in post-mortem brain of CRF-binding protein (CRF-BP), a high-affinity binding protein that inactivates CRF, and the differential distribution of CRF-BP and CRF receptors, provides the potential for improving learning and memory without stress effects of CRF receptor agonists.
Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins.
Impact
Vale et al., Los Angeles, United States. In Nature, 1991
Several groups have now reported the existence of a CRF-binding protein in human plasma which inactivates CRF and which has been proposed to prevent inappropriate pituitary-adrenal stimulation in pregnancy.
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