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CAMP responsive element modulator

CREM, ICER, inducible cAMP early repressor, cAMP-responsive element modulator
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CREB, CAN, HAD, V1a, GDNF
Papers on CREM
Model-based evaluation of cost-effectiveness of Nerve Growth Factor Inhibitors in Knee Osteoarthritis: Impact of drug cost, toxicity, and means of administration.
Katz et al., Boston, United States. In Osteoarthritis Cartilage, Jan 2016
Strategies were defined as cost-effective if their incremental cost-effectiveness ratio (ICER) was less than $100,000/quality-adjusted life year (QALY).
τCstF-64 Mediates Correct mRNA Polyadenylation and Splicing of Activator and Repressor Isoforms of the Cyclic AMP-Responsive Element Modulator (CREM) in Mouse Testis.
MacDonald et al., In Biol Reprod, Jan 2016
The cyclic AMP-responsive element modulator (CREM) gene encodes both activator and repressor isoforms that act as transcription factors to regulate spermiogenesis.
Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity.
Abderrahmani et al., Lausanne, Switzerland. In J Diabetes Res, Dec 2015
Diminution of IB1 mRNA and protein level relied on the inducible cAMP early repressor activity and proteasome-mediated degradation, respectively.
The FHL2 regulation in the transcriptional circuitry of human cancers.
Tsui et al., Hong Kong, Hong Kong. In Gene, Dec 2015
Five members have been categorized into the FHL subfamily, which are FHL1, FHL2, FHL3, FHL4 and activator of CREM in testis (ACT) in human.
The cost-effectiveness of biologics for the treatment of rheumatoid arthritis: a systematic review.
Blom et al., Helsinki, Finland. In Plos One, 2014
While considering only direct costs, the incremental cost-effectiveness ratio (ICER) of the tumor necrosis factor inhibitors (TNFi) ranged from 39,000 to 1,273,000 €/quality adjusted life year (QALY) gained in comparison to conventional disease-modifying antirheumatic drugs (cDMARDs) in cDMARD naïve patients.
Economic evaluation of first-line and maintenance treatments for advanced non-small cell lung cancer: a systematic review.
Vergnenegre et al., Paris, France. In Clinicoecon Outcomes Res, 2014
In all the analysis, bevacizumab had an ICER greater than $150,000 per quality-adjusted life-year (QALY).
Cost-effectiveness of fondaparinux versus enoxaparin in non-ST-elevation acute coronary syndrome in Canada (OASIS-5).
Sculpher et al., Canada. In Bmc Cardiovasc Disord, 2014
The model showed that: over 180 days, fondaparinux dominates enoxaparin, producing similar estimates of QALYs gained and saving $439; over a patient's lifetime, fondaparinux yields an ICER of $4293/QALY.
Cost-Effectiveness of Dolutegravir in HIV-1 Treatment-Experienced (TE) Patients in France.
Aubin et al., Paris, France. In Plos One, 2014
The incremental cost-effectiveness ratio (ICER) for DTG compared with RAL is €21,048 per QALY gained.
[Soluble forms of adenylyl cyclases of spermatozoa].
Derkach et al., In Tsitologiia, 2013
In the last years the significant progress was made in the study of the structural and functional organization and regulatory properties of sAC, their localization in the spermatozoa as well as in the investigation of intracellular cascades functionally coupled with sAC, including protein kinase A, cAMP-dependent phosphodiesterase, non-receptor tyrosine kinases, tyrosine phosphatases, transcription factors of CREB/CREM-family.
Decompensation of β-cells in diabetes: when pancreatic β-cells are on ICE(R).
Abderrahmani et al., Lille, France. In J Diabetes Res, 2013
Among the mechanisms that reduce β-cell activity is the inducible cAMP early repressor (ICER).
Cost effectiveness of fracture prevention in postmenopausal women who receive aromatase inhibitors for early breast cancer.
Elkin et al., Boston, United States. In J Clin Oncol, 2012
Outcomes were quality-adjusted life-years (QALYs), lifetime cost, and incremental cost-effectiveness ratio (ICER).
Cyclic AMP-response element modulator inhibits the promoter activity of the sodium iodide symporter gene in thyroid cancer cells.
Damante et al., Udine, Italy. In Thyroid, 2012
CREM expression is increased in thyroid cancer tissue and may play a role in the downregulation of sodium iodide symporter expression in thyroid cancer acting at the transcriptional level
CREMα overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity.
Tenbrock et al., In J Mol Cell Biol, 2012
CREMalpha overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity.
Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia.
Serretti et al., Messina, Italy. In Neurosci Lett, 2012
scriptive Statement The rsults of this study suggested the lack of influence of SNPs under investigation in the present study on the susceptibility to schizophrenia and on the response to antipsychotics.
Estrogen upregulates cyclic AMP response element modulator α expression and downregulates interleukin-2 production by human T lymphocytes.
Tsokos et al., Boston, United States. In Mol Med, 2011
Estrogen can modulate the expression of CREMalpha and lead to IL-2 suppression in human T lymphocytes, thus revealing a molecular link between hormones and the immune system in Systemic lupus erythematosus
Novel insights into the downstream pathways and targets controlled by transcription factors CREM in the testis.
Rozman et al., Ljubljana, Slovenia. In Plos One, 2011
analysis of insights into the downstream pathways and targets controlled by transcription factors CREM in the testis
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.
Kemper et al., London, United Kingdom. In Nat Immunol, 2010
In this study we demonstrate a new form of immunoregulation: engagement on CD4(+) T cells of the complement regulator CD46 promoted the effector potential of T helper type 1 cells (T(H)1 cells), but as interleukin 2 (IL-2) accumulated, it switched cells toward a regulatory phenotype, attenuating IL-2 production via the transcriptional regulator ICER/CREM and upregulating IL-10 after interaction of the CD46 tail with the serine-threonine kinase SPAK.
Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity.
Loscalzo et al., Boston, United States. In Nat Med, 2007
Aldosterone decreased G6PD expression by increasing expression of the cyclic AMP-response element modulator (CREM) to inhibit cyclic AMP-response element binding protein (CREB)-mediated G6PD transcription.
Cardiovascular disease prevention with a multidrug regimen in the developing world: a cost-effectiveness analysis.
Weinstein et al., Boston, United States. In Lancet, 2006
To compare strategies, we report incremental cost-effectiveness ratios (ICER), in US dollars per quality-adjusted life-year (QALY).
HER-2 testing and trastuzumab therapy for metastatic breast cancer: a cost-effectiveness analysis.
Weeks et al., New York City, United States. In J Clin Oncol, 2004
Outcomes were quality-adjusted life-years (QALYs), lifetime cost, and incremental cost-effectiveness ratio (ICER).
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