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Cysteine-rich with EGF-like domains 2

CRELD2, cysteine-rich with EGF-like domains 2, hCRELD2
Top mentioned proteins: Epidermal Growth Factor, CAN, ATF6, CD45, GRP78
Papers on CRELD2
Characterization of the Role of MANF in Regulating the Secretion of CRELD2.
Kiuchi et al., Gifu, Japan. In Biol Pharm Bull, 2014
We recently demonstrated that the secretion of two novel endoplasmic reticulum (ER) stress-inducible proteins, cysteine-rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) and mesencephalic astrocyte-derived neurotrophic factor (MANF), are oppositely regulated by the overexpression of 78‚ÄČkDa glucose-regulated protein (GRP78).
Characterization of V-ATPase inhibitor-induced secretion of cysteine-rich with EGF-like domains 2.
Kiuchi et al., Gifu, Japan. In Cell Biol Toxicol, 2014
We previously demonstrated that cysteine-rich with EGF-like domains 2 (CRELD2), a novel ER stress-inducible factor, is a secretory glycoprotein; however, the stimuli that induce CRELD2 secretion have not yet been characterized.
Characterization of the 5'-flanking region of the mouse asparagine-linked glycosylation 12 homolog gene.
Kiuchi et al., Gifu, Japan. In Cell Mol Biol Lett, 2013
Recently, we characterized multiple roles of the endoplasmic reticulum stress responsive element (ERSE) in the promotion of a unique head-to-head gene pair: mammalian asparagine-linked glycosylation 12 homolog (ALG12) and cysteine-rich with EGF-like domains 2 (CRELD2).
Endoplasmic reticulum (ER) stress inducible factor cysteine-rich with EGF-like domains 2 (Creld2) is an important mediator of BMP9-regulated osteogenic differentiation of mesenchymal stem cells.
Shi et al., Chongqing, China. In Plos One, 2012
Here, we focus on one such signaling mediator and investigate the functional role of cysteine-rich with EGF-like domains 2 (Creld2) in BMP9-initiated osteogenic signaling.
Biosynthesis and secretion of mouse cysteine-rich with EGF-like domains 2.
Kiuchi et al., Gifu, Japan. In Febs Lett, 2011
In this study, we found that Cysteine-rich with EGF-like domains 2 (CRELD2), a novel endoplasmic reticulum stress-inducible protein, is not only localized in the ER-Golgi apparatus but also spontaneously secreted.
An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia.
Briggs et al., Manchester, United Kingdom. In Cell Stress Chaperones, 2010
Interestingly, we also noted the upregulation of arginine-rich, mutated in early stage of tumours (ARMET) and cysteine-rich with EGF-like domain protein 2 (CRELD2) are two genes that have only recently been implicated in the UPR.
Role of an ER stress response element in regulating the bidirectional promoter of the mouse CRELD2 - ALG12 gene pair.
GeneRIF
Kiuchi et al., Gifu, Japan. In Bmc Genomics, 2009
These results show that the mouse CRELD2 and ALG12 genes are arranged as a unique bidirectional gene pair.
Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects.
Loring et al., Boston, United States. In J Neurochem, 2009
Quantitative RT-PCR corroborated gene induction of endoplasmic reticulum proteins CRELD2, PDIA6, and HERPUD1, and suppression of the pro-inflammatory cytokines IL-1beta and IL-6.
CRELD2 is a novel endoplasmic reticulum stress-inducible gene.
GeneRIF
Kiuchi et al., Gifu, Japan. In Biochem Biophys Res Commun, 2009
CRELD2 could be a novel mediator in regulating the onset and progression of various ER stress-associated diseases.
Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesis.
Schiemann et al., Aurora, United States. In Angiogenesis, 2006
In vitro assays that modeled key steps in the angiogenic process showed that several identified genes possessed pro- or anti-angiogenic activities (e.g., SMOC-2, secreted modular calcium-binding protein-2; CRELD-2, cysteine-rich with EGF-like domains-1; MAGP-2, microfibril-associated glycoprotein-2; lumican; and ECM-1, extracellular matrix protein-1).
CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region.
GeneRIF
Olson et al., Portland, United States. In Gene, 2006
Mapping of CRELD2 by FISH shows that it maps to 22q13 rather than the GenBank reported locus of 22p13.
The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits.
GeneRIF
Criado et al., Alacant, Spain. In J Neurochem, 2005
CRELD2 can act as a specific regulator of alpha4beta2 nAChR expression
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