CREG1 promotes angiogenesis and neovascularization.
In Front Biosci, 2013
It has been reported that cellular repressor of E1A-stimulated genes (CREG1) promotes human umbilical vein endothelial cell (HUVEC) proliferation, migration, and protects endothelial cell (EC) from apoptosis.
CREG1 enhances p16(INK4a) -induced cellular senescence.
Detroit, United States. In Cell Cycle, 2011
Cooperation of CREG1 and p16 (INK4a) inhibits the expression of cyclin A and cyclin B by inhibiting promoter activity thereby decreasing mRNA and protein levels; these proteins are required for S-phase entry and G2/M transition.