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Retinol binding protein 1, cellular

CRBP, Retinol-binding protein, Cellular retinol-binding protein, CRBP1
This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: ACID, RBP, CRABP, HAD, Insulin
Papers using CRBP antibodies
Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells
Supplier
Park Maiyon et al., In Molecular Cancer, 2006
... Ser15 (Cell Signaling); mouse monoclonal antibodies against Gapdh (Cell Signaling), and rabbit polyclonal antibody against CRBP-1 (Abcam).
Papers on CRBP
Retinol-binding protein-4 and hs-CRP levels in patients with migraine.
New
Inan et al., Yozgat, Turkey. In Neurol Sci, Oct 2015
Retinol-binding protein-4 (RBP4) and high-sensitivity C-reactive protein (hs-CRP) levels are associated with inflammation in patients with migraine.
The effect of topical treatment and psoriasis severity on serum retinol-binding protein-4 levels.
New
Flisiak et al., In J Dermatolog Treat, Oct 2015
Retinol-binding protein-4 (RBP-4) might play a role in psoriasis and its comorbidities.
Chronic alcohol consumption has a biphasic effect on hepatic retinoid loss.
New
Blaner et al., New York City, United States. In Faseb J, Sep 2015
Follow-up studies in mutant mice revealed roles for RBP, CRBP1, and CD36 in retinoid mobilization and extrahepatic retinoid uptake, as well as a role for CYP2E1 in the catabolism of hepatic retinoid.
Recurrent 12q13-15 chromosomal aberrations, high frequency of isocitrate dehydrogenase 1 mutations, and absence of high mobility group AT-hook 2 expression in periosteal chondromas.
New
Heim et al., Oslo, Norway. In Oncol Lett, Jul 2015
In the present study, four cases of periosteal chondromas were cytogenetically investigated and studied for the expression of high-mobility group AT-hook 2 (HMGA2), mutations in codons 132 of isocitrate dehydrogenase (IDH)1 and 172 of IDH2; mutations -C228T and -C250T in the promoter region of telomerase reverse transcriptase (TERT); and for methylation in the promoter regions of O-6-methylguanine-DNA methyltransferase (MGMT) and cellular retinol binding protein 1 (CRBP1).
Circulating retinol-binding protein 4 levels in gestational diabetes mellitus: a meta-analysis of observational studies.
Review
New
Zhong et al., Guangzhou, China. In Gynecol Endocrinol, May 2015
Retinol-binding protein 4 (RBP4) is a novel adipocyte-derived cytokine playing an important role in the regulation of energy metabolism and insulin sensitivity.
CHFR methylation strongly correlates with methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer.
New
Herman et al., Beijing, China. In Discov Med, Mar 2015
We analyzed the DNA methylation status of eight genes (CHFR, FANCF, MGMT, p16, DAPK, ASC or TMS-1, RAR-B, and CRBP1) using nested methylation-specific PCR (MSP) on over 314 paraffin-embedded, human non-small cell lung cancer samples.
Intracellular transport of fat-soluble vitamins A and E.
Review
Arai et al., Tokyo, Japan. In Traffic, 2015
Vitamin A and its derivatives, collectively called retinoids, are solubilized by intracellular retinoid-binding proteins such as cellular retinol-binding protein (CRBP), cellular retinoic acid-binding protein (CRABP) and cellular retinal-binding protein (CRALBP).
Vitamin A, cancer treatment and prevention: the new role of cellular retinol binding proteins.
Review
Orlandi et al., Roma, Italy. In Biomed Res Int, 2014
CRBP-1, the most diffuse CRBP isoform, is a small 15 KDa cytosolic protein widely expressed and evolutionarily conserved in many tissues.
Obesity Leads to Tissue, but not Serum Vitamin A Deficiency.
Gudas et al., New York City, United States. In Sci Rep, 2014
Organs from obese mice show impaired VA transcriptional signaling, including reductions in retinoic acid receptor (RARα, RARβ2 and RARγ) mRNAs and lower intracellular ROL binding protein Crbp1 (RBP1) levels in VA-storing stellate cells.
Contrasting effects of type 2 and type 1 diabetes on plasma RBP4 levels: the significance of transthyretin.
Review
Reddy et al., Hyderābād, India. In Iubmb Life, 2012
Retinol-binding protein 4 (RBP4) is the principle carrier of retinol in the human plasma, which circulates as a complex with transthyretin (TTR), a homotetrameric thyroxine transport protein.
Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXRα-induced β-catenin degradation.
GeneRIF
Li et al., Hong Kong, Hong Kong. In Int J Biochem Cell Biol, 2012
a potential role of CRBP1 in the regulation of beta-catenin turnover which can greatly affect the process of osteogenesis and adipogenesis of mesenchymal stem cells
Transient expression of cellular retinol-binding protein-1 during cardiac repair after myocardial infarction.
GeneRIF
Hao et al., Ōsaka, Japan. In Pathol Int, 2012
CRBP-1 plays a role in ventricular remodeling after myocardial infarction allegedly through its RA binding activity.
Correlation between expression of cellular retinol-binding protein 1 and its methylation status in larynx cancer.
GeneRIF
Salcedo et al., Mexico. In J Clin Pathol, 2012
Increased expression and unmethylated promoter of the CRBP1 gene could be considered as markers for larynx cancer.
Physiological insights into all-trans-retinoic acid biosynthesis.
Review
Napoli, Berkeley, United States. In Biochim Biophys Acta, 2012
The ratio apo-CRBP1/holo-CRBP1 participates by influencing retinol flux into and out of storage as retinyl esters, thereby modulating substrate to support atRA biosynthesis.
CrbpI modulates glucose homeostasis and pancreas 9-cis-retinoic acid concentrations.
GeneRIF
Napoli et al., Berkeley, United States. In Mol Cell Biol, 2011
glucose homeostasis and energy metabolism rely on Rbp1 expression and its moderation of pancreas retinol and of the autacoid 9-cis-retinoic acid.
Binding affinities of CRBPI and CRBPII for 9-cis-retinoids.
GeneRIF
Napoli et al., Berkeley, United States. In Biochim Biophys Acta, 2011
Data show that CRBPI and CRBPII bind 9-cis-retinol and 9-cis-retinal with high affinities, albeit with affinities somewhat lower than for all-trans-retinol and all-trans-retinal.
Retinaldehyde represses adipogenesis and diet-induced obesity.
Impact
Plutzky et al., Boston, United States. In Nat Med, 2007
Here we show that Rald is present in rodent fat, binds retinol-binding proteins (CRBP1, RBP4), inhibits adipogenesis and suppresses peroxisome proliferator-activated receptor-gamma and RXR responses.
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.
Impact
Kahn et al., Boston, United States. In N Engl J Med, 2006
Serum levels of retinol-binding protein 4 (RBP4), a protein secreted by adipocytes, are increased in insulin-resistant states.
Retinol-binding protein: the serum transport protein for vitamin A.
Review
Impact
Blaner, New York City, United States. In Endocr Rev, 1989
The information available regarding the chemical structure of RBP, the structure of the RBP gene, and the expression of the RBP gene has expanded dramatically in recent years.
Vitamin A transport in human vitamin A toxicity.
Impact
Goodman et al., In N Engl J Med, 1976
The concentrations of plasma retinol-binding protein and prealbumin were, in contrast, non to retinol-binding protein.
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