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Cellular retinoic acid binding protein 2

CRABP-II, CRABP2, cellular retinoic acid binding protein II
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: ACID, CRABP, RAR, CAN, CRBP
Papers on CRABP-II
Light Activated Reversible Imine Isomerization: Towards a Photochromic Protein Switch.
New
Borhan et al., East Lansing, United States. In Chembiochem, Jan 2016
UNASSIGNED: Mutants of Cellular Retinoic Acid Binding Protein II (CRABPII), engineered to bind all-trans-retinal as an iminium, demonstrate photochromism upon irradiation of light at different wavelengths.
A proteomic profiling of laser-microdissected lung adenocarcinoma cells of early lepidic-types.
New
Kato et al., Tokyo, Japan. In Clin Transl Med, Dec 2015
70 proteins including HPX, CTTN, CDH1, EGFR, MUC1 were found as LPIA-type marker candidates, 15 protein candidates for MIA-type marker included CRABP2, LMO7, and NPEP, and 26 protein candidates for AIS-type marker included LTA4H and SOD2.
Abscisic acid-induced cellular apoptosis and differentiation in glioma via the retinoid acid signaling pathway.
New
Mao et al., Shanghai, China. In Int J Cancer, Dec 2015
In glioma tissues, there was a positive correlation between the ABA levels and the transcription of cellular retinoic acid-binding protein 2 (CRABP2) and a negative correlation between the ABA levels and transcription of fatty acid binding protein 5 (FABP5).
Kruppel-like factor 2 suppresses mammary carcinoma growth by regulating retinoic acid signaling.
New
Noy et al., Cleveland, United States. In Oncotarget, Dec 2015
The partitioning of RA between these receptors is regulated by two carrier proteins: cellular retinoic acid-binding protein 2 (CRABP2), which delivers RA to RARs, and fatty acid-binding protein 5 (FABP5), which shuttles ligands to PPARβ/δ.
Cellular retinoic acid binding protein 2 inhibits osteogenic differentiation by modulating LIMK1 in C2C12 cells.
New
Pan et al., Shanghai, China. In Dev Growth Differ, Oct 2015
Cellular retinoic acid binding protein 2 (CRABP2) is essential for myoblast differentiation, however, little is known about its role in osteogenic differentiation.
CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid.
Godbout et al., Edmonton, Canada. In Mol Cancer, 2014
The expression and subcellular distribution of two RA-binding proteins, FABP5 and CRABP2, has already been shown to play critical roles in breast cancer cell response to RA. CRABP1, a third member of the RA-binding protein family, has not previously been investigated as a possible mediator of RA action in breast cancer.
Expression of retinoic acid-binding proteins and retinoic acid receptors in sebaceous cell carcinoma of the eyelids.
Yeh et al., Taiwan. In Bmc Ophthalmol, 2014
Immunohistochemical staining for β-catenin, cellular retinoic acid binding protein 1 (CRABP1), cellular retinoic acid binding protein 2 (CRABP2), fatty acid-binding protein 5 (FABP5), retinoic acid receptors (RAR-α, -β, -γ), and retinoid X receptors (RXR-α, -β, -γ) was performed on tissue samples obtained from tumor excision.
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.
Hess et al., Heidelberg, Germany. In Mol Cancer, 2014
RESULTS: Immunohistochemical analysis showed an improved prognosis of ALDH1A2(high) OPSCC only in the presence of CRABP2, an intracellular RA transporter.
Epigenetically mediated downregulation of the differentiation-promoting chaperon protein CRABP2 in astrocytic gliomas.
GeneRIF
Herold-Mende et al., Heidelberg, Germany. In Int J Cancer, 2012
Hypermethylation in the CpG island of the CRABP2 gene is associated with astrocytic gliomas.
CRABP-II methylation: a critical determinant of retinoic acid resistance of medulloblastoma cells.
GeneRIF
Liu et al., Dalian, China. In Mol Oncol, 2012
Aberrant methylation in CRABP-II reduces the expression of CRABP-II that in turn confers retinoic acid resistance in medulloblastoma cells.
Molecular determinants of retinoic acid sensitivity in pancreatic cancer.
GeneRIF
Maitra et al., Baltimore, United States. In Clin Cancer Res, 2012
Low CRABP2 is associated with pancreatic ductal adenocarcinoma.
Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation.
GeneRIF
Noy et al., Cleveland, United States. In J Biol Chem, 2012
Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation
Impaired expansion of trophoblast spheroids cocultured with endometrial cells overexpressing cellular retinoic acid-binding protein 2.
GeneRIF
Cho et al., Kwangju, South Korea. In Fertil Steril, 2011
Trophoblast spheroids cocultured with endometrial cells overexpressing CRABP2 are defective in expansion and exhibit apoptosis, suggesting that CRABP2 is involved in abnormal endometrium-trophoblast interaction, leading to implantation failure.
Retinoic acid activation of peroxisome proliferation-activated receptor delta represses obesity and insulin resistance.
Review
Wolf, Berkeley, United States. In Nutr Rev, 2010
Carrier proteins that move the RA from the cytosol into the nucleus are the fatty acid-binding protein 5 (FABP5), activating PPARdelta, and the cellular retinoic acid-binding protein II (CRABPII), activating RAR.
Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors.
Impact
Noy et al., Ithaca, United States. In Cell, 2007
Partitioning of RA between the two receptors is regulated by the intracellular lipid binding proteins CRABP-II and FABP5.
New therapeutic target for CNS injury? The role of retinoic acid signaling after nerve lesions.
Review
Mey, Aachen, Germany. In J Neurobiol, 2006
In the PNS, lesions cause RA-induced gene transcription, intracellular translocation of retinoid receptors, and increased transcription of CRBP-I, CRABP-II, and retinoid receptors.
Distinct gene expression pattern of malignant hematopoietic stem and progenitor cells in polycythemia vera.
Review
Kronenwett et al., Düsseldorf, Germany. In Ann N Y Acad Sci, 2005
It is interesting that three retinoid receptors were overexpressed in PV-CD34(+) cells--retinoic acid receptor beta (RARbeta), retinoid X receptor beta (RXRbeta), and cellular retinoic acid binding protein 2 (CRABP2).
Gene expression studies provide clues to the pathogenesis of uterine leiomyoma: new evidence and a systematic review.
Review
Toniolo et al., New York City, United States. In Hum Reprod, 2005
A comparative analysis including eight previous gene expression studies revealed eight prominent genes (ADH1, ATF3, CRABP2, CYR61, DPT, GRIA2, IGF2, MEST) identified by at least five different studies, eleven genes (ALDH1, CD24, CTGF, DCX, DUSP1, FOS, GAGEC1, IGFBP6, PTGDS, PTGER3, TYMS) reported by four studies, twelve genes (ABCA, ANXA1, APM2, CCL21, CDKN1A, CRMP1, EMP1, ESR1, FY, MAP3K5, TGFBR2, TIMP3) identified by three studies, and 40 genes reported by two different studies.
Cellular retinoic acid-binding protein II: a coactivator of the transactivation by the retinoic acid receptor complex RAR.RXR.
Review
Wolf, Berkeley, United States. In Nutr Rev, 2000
CRABPII, when combined with its retinoic acid (RA) ligand, interacts specifically with the liganded RA receptor complex (RAR.RXR), which is bound to the RA response elements of particular genes in order to greatly activate their expression.
All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs.
Impact
Chambon et al., Strasbourg, France. In Cell, 1992
Two cooperating retinoic acid response elements (RAREs) in the cellular retinoic acid-binding protein II (CRABPII) gene mediate differential transcriptional transactivation by retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in P19 embryonal carcinoma cells.
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