gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 09 Dec 2014.

Growth arrest and DNA-damage-inducible, gamma

Cr6, GADD45gamma, Gadd45g
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GADD45, GADD45B, CAN, V1a, PCNA
Papers on Cr6
CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease.
New
Mook-Jung et al., Seoul, South Korea. In Cell Death Differ, 07 Dec 2014
In this study, we report that CR6-interacting factor 1 (Crif1), a mitochondrial inner membrane protein, is a key player in Aβ-induced mitochondrial dysfunction.
Requirement for CRIF1 in RNA interference and Dicer-2 stability.
New
Li et al., In Rna Biol, 01 Dec 2014
We identified the Drosophila homolog of the mammalian CR6-interacting factor 1 (CRIF1), also known as growth arrest and DNA-damage-inducible 45-gamma interacting protein (Gadd45GIP1), as a potential new regulator of the RNAi pathway.
Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells.
New
Rodrigues et al., Lisbon, Portugal. In Chem Biol Interact, Aug 2014
The gene expression profile revealed an overall down regulation of DNA damage response genes after exposure to myristicin, with significant under-expression of genes associated with nucleotide excision repair (ERCC1), double strand break repair (RAD50, RAD51) and DNA damage signalling (ATM) and stress response (GADD45A, GADD45G).
Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells.
New
Rieger et al., Frankfurt am Main, Germany. In Stem Cell Reports, Aug 2014
We identified the tumor suppressor GADD45G as an instructor of LT-HSC differentiation under the control of differentiation-promoting cytokine receptor signaling.
Murine norovirus protein NS1/2 aspartate to glutamate mutation, sufficient for persistence, reorients side chain of surface exposed tryptophan within a novel structured domain.
New
Krezel et al., San Diego, United States. In Proteins, Jul 2014
Using solution nuclear magnetic resonance methods, we determined folded NS1/2 domain structures from a nonpersistent murine norovirus strain CW3, a persistent strain CR6, and a persistent mutant strain CW3(D94E).
Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma.
Review
New
Klibanski et al., Boston, United States. In Mol Cell Endocrinol, May 2014
The RB group includes CDKN2A, CDKN2B, CDKN2C, RB1, BMP4, CDH1, CDH13, GADD45B and GADD45G; AIP and MEN1 genes also belong to this group.
Mechanism of androgen receptor corepression by CKβBP2/CRIF1, a multifunctional transcription factor coregulator expressed in prostate cancer.
New
French et al., Chapel Hill, United States. In Mol Cell Endocrinol, Feb 2014
The transcription factor coregulator Casein kinase IIβ-binding protein 2 or CR6-interacting factor 1 (CKβBP2/CRIF1) binds the androgen receptor (AR) in prostate cancer cells and in response to dihydrotestosterone localizes with AR on the prostate-specific antigen gene enhancer, but does not bind DNA suggesting CKβBP2/CRIF1 localization in chromatin is determined by AR.
CRIF1 interacting with CDK2 regulates bone marrow microenvironment-induced G0/G1 arrest of leukemia cells.
New
Li et al., Chongqing, China. In Plos One, Dec 2013
BACKGROUND: To assess the level of CR6-interacting factor 1 (CRIF1), a cell cycle negative regulator, in patients with leukemia and investigate the role of CRIF1 in regulating leukemia cell cycle.
Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.
GeneRIF
Niehrs et al., Heidelberg, Germany. In Gene Expr Patterns, 2011
Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.
Crystal structure of human Gadd45γ [corrected] reveals an active dimer.
GeneRIF
Rao et al., Beijing, China. In Protein Cell, 2011
These results reveal the mechanism of self-association by Gadd45 proteins and the importance of this self-association for their biological function
Human-specific loss of regulatory DNA and the evolution of human-specific traits.
Impact
Kingsley et al., Stanford, United States. In Nature, 2011
Another deletion removes a forebrain subventricular zone enhancer near the tumour suppressor gene growth arrest and DNA-damage-inducible, gamma (GADD45G), a loss correlated with expansion of specific brain regions in humans.
Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy.
GeneRIF
Libermann et al., Cape Town, South Africa. In Plos One, 2010
Data show that mda-7/IL-24 activation leads to upregulation of growth arrest and DNA damage inducible (GADD) 45 alpha and gamma and JNK activation.
GADD45gamma: a new vitamin D-regulated gene that is antiproliferative in prostate cancer cells.
GeneRIF
Burnstein et al., Miami, United States. In Endocrinology, 2010
The induction of GADD45gamma gene expression by 1,25-(OH)2D3 may mark therapeutic response in prostate cancer.
Direct transcriptional induction of Gadd45gamma by Ascl1 during neuronal differentiation.
GeneRIF
Uhler et al., Ann Arbor, United States. In Mol Cell Neurosci, 2010
Results identify Gadd45gamma as a direct transcriptional target of Ascl1.
Recent progress in studies of pituitary tumor pathogenesis.
Review
Osamura et al., Isehara, Japan. In Endocrine, 2005
Defects or overexpression of cell cycle regulators, such as CDK inhibitors, PTTG, and GADD45gamma, result in the abnormal proliferation of pituitary cells.
Myeloid differentiation (MyD) primary response genes in hematopoiesis.
Review
Hoffman et al., Philadelphia, United States. In Blood Cells Mol Dis, 2003
Myeloid differentiation (MyD) primary response and growth arrest DNA-damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45a MyD118/Gadd45b, GADD45g, MyD116/Gadd34) genes, that have been cloned by virtue of being coordinately induced upon the onset of terminal myeloid differentiation.
Myeloid differentiation (MyD) primary response genes in hematopoiesis.
Review
Hoffman et al., Philadelphia, United States. In Oncogene, 2002
Myeloid Differentiation (MyD) primary response and Growth Arrest DNA-Damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45alpha MyD118/Gadd45beta, GADD45gamma, MyD116/Gadd34) genes, that have been cloned by virtue of there being co-ordinately induced upon the onset of terminal myeloid differentiation.
Myeloid differentiation (MyD)/growth arrest DNA damage (GADD) genes in tumor suppression, immunity and inflammation.
Review
Hoffman et al., Philadelphia, United States. In Leukemia, 2002
Myeloid differentiation (MyD) primary response and growth arrest DNA damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45alpha, MyD118/Gadd45beta, GADD45gamma, MyD116/ Gadd34) genes, that have been cloned by virtue of being co-ordinately induced upon the onset of terminal myeloid differentiation and following exposure of cells to stress stimuli.
GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells.
Impact
Flavell et al., New Haven, United States. In Immunity, 2001
Here, we show that the expression of GADD45gamma is induced during T cell activation and that the level of expression is higher in TH1 cells than in TH2 cells.
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.
Impact
Saito et al., Boston, United States. In Cell, 1998
Using a yeast two-hybrid method, three related proteins, GADD45alpha (= GADD45), GADD45, (= MyD118), and GADD45gamma, were identified that bound to an N-terminal domain of MTK1.
share on facebooktweetadd +1mail to friends