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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Apr 2015.

Growth arrest and DNA-damage-inducible, gamma

Cr6, GADD45gamma, Gadd45g
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GADD45, GADD45B, CAN, V1a, PCNA
Papers on Cr6
Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure.
New
Shong et al., Taejŏn, South Korea. In Diabetologia, 30 Apr 2015
CR6-interacting factor-1 (CRIF1) is a mitochondrial protein essential for the synthesis and formation of the OxPhos complex in the inner mitochondrial membrane.
Molecular signatures in the prevention of radiation damage by the synergistic effect of N-acetyl cysteine and qingre liyan decoction, a traditional chinese medicine, using a 3-dimensional cell culture model of oral mucositis.
New
Chow et al., Pomona, United States. In Evid Based Complement Alternat Med, Dec 2014
DNA repair genes (XCP, GADD45G, RAD9, and XRCC1), protective genes (EGFR and PPARD), and genes of the NFκB pathway were upregulated.
CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease.
New
Mook-Jung et al., Seoul, South Korea. In Cell Death Differ, Dec 2014
In this study, we report that CR6-interacting factor 1 (Crif1), a mitochondrial inner membrane protein, is a key player in Aβ-induced mitochondrial dysfunction.
Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells.
New
Rodrigues et al., Lisbon, Portugal. In Chem Biol Interact, Aug 2014
The gene expression profile revealed an overall down regulation of DNA damage response genes after exposure to myristicin, with significant under-expression of genes associated with nucleotide excision repair (ERCC1), double strand break repair (RAD50, RAD51) and DNA damage signalling (ATM) and stress response (GADD45A, GADD45G).
Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells.
New
Rieger et al., Frankfurt am Main, Germany. In Stem Cell Reports, Aug 2014
We identified the tumor suppressor GADD45G as an instructor of LT-HSC differentiation under the control of differentiation-promoting cytokine receptor signaling.
Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma.
Review
New
Klibanski et al., Boston, United States. In Mol Cell Endocrinol, May 2014
The RB group includes CDKN2A, CDKN2B, CDKN2C, RB1, BMP4, CDH1, CDH13, GADD45B and GADD45G; AIP and MEN1 genes also belong to this group.
CRIF1 interacting with CDK2 regulates bone marrow microenvironment-induced G0/G1 arrest of leukemia cells.
Li et al., Chongqing, China. In Plos One, 2013
BACKGROUND: To assess the level of CR6-interacting factor 1 (CRIF1), a cell cycle negative regulator, in patients with leukemia and investigate the role of CRIF1 in regulating leukemia cell cycle.
Requirement for CRIF1 in RNA interference and Dicer-2 stability.
Li et al., San Diego, United States. In Rna Biol, 2013
We identified the Drosophila homolog of the mammalian CR6-interacting factor 1 (CRIF1), also known as growth arrest and DNA-damage-inducible 45-gamma interacting protein (Gadd45GIP1), as a potential new regulator of the RNAi pathway.
Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.
GeneRIF
Niehrs et al., Heidelberg, Germany. In Gene Expr Patterns, 2011
Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.
Crystal structure of human Gadd45γ [corrected] reveals an active dimer.
GeneRIF
Rao et al., Beijing, China. In Protein Cell, 2011
These results reveal the mechanism of self-association by Gadd45 proteins and the importance of this self-association for their biological function
Human-specific loss of regulatory DNA and the evolution of human-specific traits.
Impact
Kingsley et al., Stanford, United States. In Nature, 2011
Another deletion removes a forebrain subventricular zone enhancer near the tumour suppressor gene growth arrest and DNA-damage-inducible, gamma (GADD45G), a loss correlated with expansion of specific brain regions in humans.
Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy.
GeneRIF
Libermann et al., Cape Town, South Africa. In Plos One, 2010
Data show that mda-7/IL-24 activation leads to upregulation of growth arrest and DNA damage inducible (GADD) 45 alpha and gamma and JNK activation.
GADD45gamma: a new vitamin D-regulated gene that is antiproliferative in prostate cancer cells.
GeneRIF
Burnstein et al., Miami, United States. In Endocrinology, 2010
The induction of GADD45gamma gene expression by 1,25-(OH)2D3 may mark therapeutic response in prostate cancer.
Direct transcriptional induction of Gadd45gamma by Ascl1 during neuronal differentiation.
GeneRIF
Uhler et al., Ann Arbor, United States. In Mol Cell Neurosci, 2010
Results identify Gadd45gamma as a direct transcriptional target of Ascl1.
Recent progress in studies of pituitary tumor pathogenesis.
Review
Osamura et al., Isehara, Japan. In Endocrine, 2005
Defects or overexpression of cell cycle regulators, such as CDK inhibitors, PTTG, and GADD45gamma, result in the abnormal proliferation of pituitary cells.
Myeloid differentiation (MyD) primary response genes in hematopoiesis.
Review
Hoffman et al., Philadelphia, United States. In Blood Cells Mol Dis, 2003
Myeloid differentiation (MyD) primary response and growth arrest DNA-damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45a MyD118/Gadd45b, GADD45g, MyD116/Gadd34) genes, that have been cloned by virtue of being coordinately induced upon the onset of terminal myeloid differentiation.
Myeloid differentiation (MyD) primary response genes in hematopoiesis.
Review
Hoffman et al., Philadelphia, United States. In Oncogene, 2002
Myeloid Differentiation (MyD) primary response and Growth Arrest DNA-Damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45alpha MyD118/Gadd45beta, GADD45gamma, MyD116/Gadd34) genes, that have been cloned by virtue of there being co-ordinately induced upon the onset of terminal myeloid differentiation.
Myeloid differentiation (MyD)/growth arrest DNA damage (GADD) genes in tumor suppression, immunity and inflammation.
Review
Hoffman et al., Philadelphia, United States. In Leukemia, 2002
Myeloid differentiation (MyD) primary response and growth arrest DNA damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45alpha, MyD118/Gadd45beta, GADD45gamma, MyD116/ Gadd34) genes, that have been cloned by virtue of being co-ordinately induced upon the onset of terminal myeloid differentiation and following exposure of cells to stress stimuli.
GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells.
Impact
Flavell et al., New Haven, United States. In Immunity, 2001
Here, we show that the expression of GADD45gamma is induced during T cell activation and that the level of expression is higher in TH1 cells than in TH2 cells.
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.
Impact
Saito et al., Boston, United States. In Cell, 1998
Using a yeast two-hybrid method, three related proteins, GADD45alpha (= GADD45), GADD45, (= MyD118), and GADD45gamma, were identified that bound to an N-terminal domain of MTK1.
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