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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Growth arrest and DNA-damage-inducible, gamma

Cr6, GADD45gamma, Gadd45g
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GADD45, GADD45B, CAN, V1a, CRIF1
Papers on Cr6
The High Affinity Binding Site on Plasminogen Activator Inhibitor-1 (PAI-1) for the Low Density Lipoprotein Receptor-related Protein (LRP1) Is Composed of Four Basic Residues.
New
Dolmer et al., Chicago, United States. In J Biol Chem, Feb 2016
We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.
Nuclear spheres modulate the expression of BEST1 and GADD45G.
New
Müller et al., Bochum, Germany. In Cell Signal, Jan 2016
Nuclear spheres are composed of FE65, TIP60, BLM and other yet unknown proteins.
Treatment with a nucleoside polymerase inhibitor reduces shedding of murine norovirus in stool to undetectable levels without emergence of drug-resistant variants.
New
Neyts et al., Leuven, Belgium. In Antimicrob Agents Chemother, Jan 2016
We established a mouse model for persistent norovirus infection [using mouse norovirus (MNV.CR6 strain).
SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells.
New
Liu et al., Shanghai, China. In Oncotarget, Nov 2015
Our previous study has shown that the downregulation of growth arrest and DNA damage 45G (GADD45G) contributes to senescence bypass in hepatocellular carcinoma (HCC).
Promoter methylation, mRNA expression of goat tumor‑associated genes and mRNA expression of DNA methyltransferase in enzootic nasal tumors.
New
Yan et al., Chengdu, China. In Mol Med Report, Oct 2015
Methylation‑specific polymerase chain reaction and SYBR Green reverse transcription‑quantitative polymerase chain reaction were used to detect the methylation status and the mRNA expression levels of DNA methyltransferases (DNMTs), O6‑methylguanine‑DNA methyltransferase (MGMT), the tumor suppressor genes P73, P53, GADD45G, CHFR and THBS1, the transcription factor CEBPA, the proto‑oncogenes KRAS, NRAS and C‑myc and EGFR in 24 nasal tumor tissue samples and 20 normal nasal epithelia tissue samples.
T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration.
New
Impact
Ashton-Rickardt et al., Zürich, Switzerland. In Science, Jun 2015
Through interaction with CR6 interacting factor (CRIF1), LEM controlled the levels of oxidative phosphorylation (OXPHOS) complexes and respiration, resulting in the production of pro-proliferative mitochondrial reactive oxygen species (mROS).
Lymphocyte-specific protein tyrosine kinase (Lck) interacts with CR6-interacting factor 1 (CRIF1) in mitochondria to repress oxidative phosphorylation.
Yu et al., North Chicago, United States. In Bmc Cancer, 2014
Proteomics identified CR6-interacting factor 1 (CRIF1) as the novel Lck-interacting protein.
Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma.
Review
Klibanski et al., Boston, United States. In Mol Cell Endocrinol, 2014
The RB group includes CDKN2A, CDKN2B, CDKN2C, RB1, BMP4, CDH1, CDH13, GADD45B and GADD45G; AIP and MEN1 genes also belong to this group.
Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.
GeneRIF
Niehrs et al., Heidelberg, Germany. In Gene Expr Patterns, 2011
Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.
Crystal structure of human Gadd45γ [corrected] reveals an active dimer.
GeneRIF
Rao et al., Beijing, China. In Protein Cell, 2011
These results reveal the mechanism of self-association by Gadd45 proteins and the importance of this self-association for their biological function
Human-specific loss of regulatory DNA and the evolution of human-specific traits.
Impact
Kingsley et al., Stanford, United States. In Nature, 2011
Another deletion removes a forebrain subventricular zone enhancer near the tumour suppressor gene growth arrest and DNA-damage-inducible, gamma (GADD45G), a loss correlated with expansion of specific brain regions in humans.
Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy.
GeneRIF
Libermann et al., Cape Town, South Africa. In Plos One, 2010
Data show that mda-7/IL-24 activation leads to upregulation of growth arrest and DNA damage inducible (GADD) 45 alpha and gamma and JNK activation.
GADD45gamma: a new vitamin D-regulated gene that is antiproliferative in prostate cancer cells.
GeneRIF
Burnstein et al., Miami, United States. In Endocrinology, 2010
The induction of GADD45gamma gene expression by 1,25-(OH)2D3 may mark therapeutic response in prostate cancer.
Direct transcriptional induction of Gadd45gamma by Ascl1 during neuronal differentiation.
GeneRIF
Uhler et al., Ann Arbor, United States. In Mol Cell Neurosci, 2010
Results identify Gadd45gamma as a direct transcriptional target of Ascl1.
Recent progress in studies of pituitary tumor pathogenesis.
Review
Osamura et al., Isehara, Japan. In Endocrine, 2005
Defects or overexpression of cell cycle regulators, such as CDK inhibitors, PTTG, and GADD45gamma, result in the abnormal proliferation of pituitary cells.
Myeloid differentiation (MyD) primary response genes in hematopoiesis.
Review
Hoffman et al., Philadelphia, United States. In Blood Cells Mol Dis, 2003
Myeloid differentiation (MyD) primary response and growth arrest DNA-damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45a MyD118/Gadd45b, GADD45g, MyD116/Gadd34) genes, that have been cloned by virtue of being coordinately induced upon the onset of terminal myeloid differentiation.
Myeloid differentiation (MyD) primary response genes in hematopoiesis.
Review
Hoffman et al., Philadelphia, United States. In Oncogene, 2002
Myeloid Differentiation (MyD) primary response and Growth Arrest DNA-Damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45alpha MyD118/Gadd45beta, GADD45gamma, MyD116/Gadd34) genes, that have been cloned by virtue of there being co-ordinately induced upon the onset of terminal myeloid differentiation.
Myeloid differentiation (MyD)/growth arrest DNA damage (GADD) genes in tumor suppression, immunity and inflammation.
Review
Hoffman et al., Philadelphia, United States. In Leukemia, 2002
Myeloid differentiation (MyD) primary response and growth arrest DNA damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45alpha, MyD118/Gadd45beta, GADD45gamma, MyD116/ Gadd34) genes, that have been cloned by virtue of being co-ordinately induced upon the onset of terminal myeloid differentiation and following exposure of cells to stress stimuli.
GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells.
Impact
Flavell et al., New Haven, United States. In Immunity, 2001
Here, we show that the expression of GADD45gamma is induced during T cell activation and that the level of expression is higher in TH1 cells than in TH2 cells.
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.
Impact
Saito et al., Boston, United States. In Cell, 1998
Using a yeast two-hybrid method, three related proteins, GADD45alpha (= GADD45), GADD45, (= MyD118), and GADD45gamma, were identified that bound to an N-terminal domain of MTK1.
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