GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Growth arrest and DNA-damage-inducible, gamma
Cr6, GADD45gamma, Gadd45g
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
Cr6
BAY11 enhances OCT4 synthetic mRNA expression in adult human skin cells.
New
In Stem Cell Res Ther, 06 Mar 2013
The increased levels of OCT4 resulted in significantly increased expression of genes downstream of OCT4, including the previously identified SPP1, DUSP4 and GADD45G, suggesting the expressed OCT4 was functional.
The Microarray Gene Profiling Analysis of Glioblastoma Cancer Cells Reveals Genes Affected by Fak Inhibitor Y15 and Combination of Y15 and Temozolomide.
New
Buffalo, United States. In Anticancer Agents Med Chem, 24 Feb 2013
Among genes up-regulated by Y15 and temozolomide more significantly than by each agent alone were: COX7B; interferon, gamma-inducible transcript: IFI16; DDIT4; GADD45G and down-regulated: KIF3A, AKT1; ABL; JAK1, GLI3 and ALDH1A3.
A single-amino-acid change in murine norovirus NS1/2 is sufficient for colonic tropism and persistence.
New
Saint Louis, United States. In J Virol, Jan 2013
We have used recombinant cDNA clones of representative persistent (CR6) and nonpersistent (CW3) strains to identify a domain within the nonstructural gene NS1/2 that is necessary and sufficient for persistence.
A cysteine-reactive alkyl hydroquinone modifies topoisomerase IIα, enhances DNA breakage, and induces apoptosis in cancer cells.
New
Taipei, Taiwan. In Chem Res Toxicol, Dec 2012
In Huh7 cells, HQ17(3) treatment caused prompt inhibition of DNA synthesis and consequently induced the expression of DNA damage-related genes DDIT3, GADD45A, and GADD45G.
GADD45G functions in male sex determination by promoting p38 signaling and Sry expression.
New
Mainz, Germany. In Dev Cell, Dec 2012
Here we show that mice mutant for the stress-response gene Gadd45g display complete male-to-female sex reversal.
Transcriptional regulatory networks in human lung adenocarcinoma.
New
Zhengzhou, China. In Mol Med Report, Nov 2012
Among these genes, it appears that: PPARG promotes the PPAR signaling pathway via the upregulation of lipoprotein lipase (LPL) expression, but suppresses the cell cycle pathway via downregulation of growth arrest and DNA-damage-inducible, γ (GADD45G) expression; ETV4 stimulates matrix metallopeptidase 9 (MMP9) expression to induce the bladder cancer pathway; FLI upregulates transforming growth factor, β receptor II (TGFBR2) expression to activate TGF-β signaling and upregulates cyclin D3 (CCND3) expression to promote the cell cycle pathway; NFKB1 upregulates interleukin 1, β (IL-1B) expression and initiates the prostate cancer pathway; CEBPB upregulates IL-6 expression and promotes pathways in cancer; and TAL1 promotes kinase insert domain receptor (KDR) expression to promote the TGF-β signaling pathway.
p53-Pathway activity and apoptosis in hydrogen sulfide-exposed stem cells separated from human gingival epithelium.
New
Tokyo, Japan. In J Periodontal Res, Nov 2012
growth arrest and DNA-damage-inducible, gamma ( GADD45G ) family and serine/threonine-protein kinase Chk2 ( CHEK2)] were also increased.
Human-specific loss of regulatory DNA and the evolution of human-specific traits.
Impact
Stanford, United States. In Nature, 2011
Another deletion removes a forebrain subventricular zone enhancer near the tumour suppressor gene growth arrest and DNA-damage-inducible, gamma (GADD45G), a loss correlated with expansion of specific brain regions in humans.
GADD45gamma: a new vitamin D-regulated gene that is antiproliferative in prostate cancer cells.
GeneRIF
Miami, United States. In Endocrinology, 2010
The induction of GADD45gamma gene expression by 1,25-(OH)2D3 may mark therapeutic response in prostate cancer.
Semi-quantitative detection of GADD45-gamma methylation levels in gastric, colorectal and pancreatic cancers using methylation-sensitive high-resolution melting analysis.
GeneRIF
China. In J Cancer Res Clin Oncol, 2010
Epigenetic regulation of GADD45G is associated with carcinogenesis in stomach, colorectal and pancreateic cancers.
Direct transcriptional induction of Gadd45gamma by Ascl1 during neuronal differentiation.
GeneRIF
Ann Arbor, United States. In Mol Cell Neurosci, 2010
Results identify Gadd45gamma as a direct transcriptional target of Ascl1.
Gadd45b and Gadd45g are important for anti-tumor immune responses.
GeneRIF
Pittsburgh, United States. In Eur J Immunol, 2009
members of the Gadd45 gene family are important for anti-tumor immune responses.
Apoptosis of glomerular mesangial cells induced by sublytic C5b-9 complexes in rats with Thy-1 nephritis is dependent on Gadd45 gamma upregulation.
GeneRIF
Nanjing, China. In Eur J Immunol, 2009
Gadd45 gamma gene expression is involved in regulating glomerular mesangial cell apoptosis mediated by sublytic C5b-9 in Thy-1 nephritis
Recent progress in studies of pituitary tumor pathogenesis.
Review
Isehara, Japan. In Endocrine, 2005
Defects or overexpression of cell cycle regulators, such as CDK inhibitors, PTTG, and GADD45gamma, result in the abnormal proliferation of pituitary cells.
Myeloid differentiation (MyD) primary response genes in hematopoiesis.
Review
Philadelphia, United States. In Blood Cells Mol Dis, 2003
Myeloid differentiation (MyD) primary response and growth arrest DNA-damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45a MyD118/Gadd45b, GADD45g, MyD116/Gadd34) genes, that have been cloned by virtue of being coordinately induced upon the onset of terminal myeloid differentiation.
Myeloid differentiation (MyD) primary response genes in hematopoiesis.
Review
Philadelphia, United States. In Oncogene, 2002
Myeloid Differentiation (MyD) primary response and Growth Arrest DNA-Damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45alpha MyD118/Gadd45beta, GADD45gamma, MyD116/Gadd34) genes, that have been cloned by virtue of there being co-ordinately induced upon the onset of terminal myeloid differentiation.
Myeloid differentiation (MyD)/growth arrest DNA damage (GADD) genes in tumor suppression, immunity and inflammation.
Review
Philadelphia, United States. In Leukemia, 2002
Myeloid differentiation (MyD) primary response and growth arrest DNA damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45alpha, MyD118/Gadd45beta, GADD45gamma, MyD116/ Gadd34) genes, that have been cloned by virtue of being co-ordinately induced upon the onset of terminal myeloid differentiation and following exposure of cells to stress stimuli.
Proliferating cell nuclear antigen (PCNA): ringmaster of the genome.
Review
United States. In Int J Radiat Biol, 2001
The PCNA gene is induced by p53, while PCNA protein interacts with p53-controlled proteins Gadd45, MyD118, CR6 and, most importantly, p21, in the process of deciding cell fate.
GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells.
Impact
New Haven, United States. In Immunity, 2001
Here, we show that the expression of GADD45gamma is induced during T cell activation and that the level of expression is higher in TH1 cells than in TH2 cells.
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.
Impact
Boston, United States. In Cell, 1998
Using a yeast two-hybrid method, three related proteins, GADD45alpha (= GADD45), GADD45, (= MyD118), and GADD45gamma, were identified that bound to an N-terminal domain of MTK1.
